New York University

Masonry Mortar with Carbide Sludge and Limestone for Enhanced Hydration and Carbonation Performance

Abstract This investigation utilized carbide sludge, predominantly composed of calcium hydroxide, with or without ground limestone, to partially replace portland cement for masonry mortar applications. Accelerated carbonation was employed to simulate the long-term environmental e...

Highlights of the 2025 American Joint Replacement Registry Annual Report

The 2025 American Joint Replacement Registry Annual Report includes 4.6 million hip and knee arthroplasty procedures, with 4,434,668 validated cases, representing a 20% increase from the prior report. Registry participation continues to expand, with contributions from over 5000 s...

Associations of ambient temperature and PM2.5 concentration with temporal variability in emergency department visits for acute gastrointestinal illnesses in central Bangkok, Thailand: a 5-year retrospective analysis

The combined effects of temperature and air pollution on acute gastrointestinal (GI) illnesses remain underexplored in tropical settings. This study examined the association between ambient temperature, fine particulate matter (PM2.5), and emergency department (ED) visits for gas...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

The interplay of air pollution with plasma neurodegenerative markers and metabolome for dementia, Parkinson’s disease and all-cause mortality risks and transitions: The UK Biobank study

We investigated the joint associations of circulating neurodegeneration markers—neurofilament light (NfL) and glial fibrillary acidic protein (GFAP)—ambient air pollution, and plasma metabolomic profiles with transitions from a healthy state to dementia, Parkinson’s disease (PD),...

Interpretable distillation reveals that deep learning splicing models suffer from pervasive confounders and blind spots

BACKGROUND: Predicting RNA splicing from genomic sequence is a crucial task for understanding gene regulation and interpreting genetic variation. Recent deep learning advancements have led to splicing prediction algorithms that achieve state-of-the-art performance compared to ear...

Bayesian inference of lineage trees by joint analysis of single-cell multimodal lineage-tracing data with BiLinT

Abstract The advent of single-cell lineage-tracing technologies has enabled simultaneous measurement of gene expression and lineage barcodes. However, integrating these modalities for high-resolution lineage reconstruction has remained challenging due to limitations of methods th...

Longitudinal weighted and trimmed treatment effects with flip interventions

Weighting and trimming are popular methods for addressing positivity violations in causal inference. While well-studied with single-timepoint data, standard methods do not easily generalize to longitudinal data and remain vulnerable to time-varying positivity violations. We exten...

Hypothalamic representation of aggressiveness across mouse strains

Aggression is an innate behavior conserved across species, serving as a critical means to compete for food, mating opportunities, and other essential resources. A central question in aggression research is the extent to which inter-individual variability in aggression is shaped b...

A biobank-scale method for learning modulators of gene-environment interaction underlying human complex traits from multiple environmental exposures

Abstract It is increasingly recognized that genetic effects on complex traits and diseases are shaped by environmental context. Biobanks that measure diverse environmental exposures alongside genotypes and phenotypes at scale enable systematic study of gene-environment (G×E) inte...

SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease...

Conformal network link prediction with false discovery rate control under unstructured missingness

We propose a new method for predicting multiple missing links in partially observed networks while controlling the false discovery rate (FDR), a largely unresolved challenge in network analysis. The main difficulty lies in handling complex dependencies and unknown missing pattern...

Itō and Itō-Wentzell chain rule for flows of conditional laws of continuous semimartingales: an easy approach

We provide a general Itō-Wentzell formula for a random field of maps on the Wasserstein space of probability measures, defined by continuous semimartingales, and evaluated along the flow of conditional distributions of another continuous semimartingale. Our method follows standar...

Reliability of a Home-Based Smartphone Balance Assessment in Healthy Middle-Aged and Older Adults

Smartphone accelerometry could enable longitudinal home-based balance testing, yet its reliability across tasks and outcome measures must be established. We assessed the test–retest reliability and measurement precision of a custom smartphone balance application. Sixty-nine healt...

Joint-RPCA: domain-aware multi-omics integration for systems microbiology

Integrating multi-omics data is essential for microbiome research, as microbial communities are shaped by and respond to interdependent processes, including taxonomic composition, metabolite production and utilization, and gene expression. However, accurately capturing ecosystem-...

Effect of Fitzpatrick Skin Type Prompting on Diagnostic Accuracy in Multimodal Large Language Models: A Within-Image Experimental Study

Multimodal large language models are increasingly used for dermatologic queries, but whether Fitzpatrick skin type (FST) labels affect diagnostic accuracy is unknown. We evaluated 656 biopsy-confirmed photographs from the Diverse Dermatology Images (DDI) dataset under no-FST, DDI...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Study protocol for first national vasa previa perinatal registry

Vasa previa is a rare but potentially catastrophic obstetric condition characterized by unprotected fetal blood vessels over or adjacent to the internal cervical os. Although advances in prenatal ultrasound have dramatically improved neonatal survival through planned cesarean del...

Importance of Global Health Opportunities in Residency Selection Among Otolaryngology Applicants

ABSTRACT Introduction Global health has become an increasing priority in medical training. In this cross‐sectional study, we seek to evaluate the importance of a residency program's global health opportunities on otolaryngology‐head and neck surgery (OHNS) applicants' residency s...

The Echo-Chamber Trap: Symbolic Self-Completion and the Stagnation of Digital Activism

Social movements increasingly rely on digital platforms to mobilize support, raise awareness, and coordinate collective action. At the same time, however, the rise of online activism has intensified concerns regarding “slacktivism”, namely forms of symbolic and low-effort engagem...