McGill University

Management of Soft Tissue and Visceral Leiomyosarcomas

Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize manag...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...

Ecological performance of cultivated and feral populations of an invasive freshwater fish under current and near-future climatic conditions

Goldfish (Carassius auratus), a globally invasive species, is increasing in abundance in lakes and ponds within the Laurentian Great Lakes region. We hypothesized that current and future selection pressures imposed on feral goldfish populations adapted to urban and natural ponds...

Long-Term Clinical and Economic Impact of Automated Insulin Delivery Systems Use in Pediatric and Adolescents Type 1 Diabetes: Results Across Australia, Canada, the UK, and the USA

BACKGROUND AND AIMS: Automated Insulin Delivery (AID) systems are the recommended standard of care for Type 1 Diabetes (T1D) management in children and adolescents, according to latest international guidelines. This study aims to assess the cost-effectiveness of AID systems for p...

Combining Implementation and Data Sciences to Accelerate Evidence Integration into Healthcare – ImpleMATE

Background The translation of research evidence into routine healthcare practice is often slow and inconsistent, even timely implementation can significantly improve patient outcomes. While implementation science offers strategies to close this gap, current approaches are frequen...

Strong coupling between RF photons and plasmons of electrons on liquid helium

Plasmons, arising from the collective motion of electrons, can interact strongly with electromagnetic fields or photons; this capability has been exploited across a broad range of applications, from chemical reactivity to biosensing. Recently, there has been growing interest in p...

Diagnostic yield of repeat CT pulmonary angiography after a negative examination in the emergency department

PURPOSE: Although repeat CT pulmonary angiography (CTPA) after a negative index examination in the emergency department (ED) is common, its diagnostic utility remains uncertain. This study aimed to determine the incidence and diagnostic yield of repeat CTPA after a negative index...

Tree-based structural equation model for assessing measurement invariance in patient-reported outcome measures

Evidence of measurement invariance (MI) is essential to ensure that scores based on patient-reported outcome measures (PROMs) are comparable across groups or over time. Conventional methods for evaluating MI in PROMs are mostly group-based methods that require that relevant diffe...

Hydrazones as organometallic equivalents in cross-coupling reactions

While transition-metal-catalyzed cross-coupling reactions are among the most important tools in modern organic synthesis; however, they rely on preformed organometallic reagents, which often require multistep preparation, exhibit air and moisture sensitivity, and generate stoichi...

Integrative plasma proteomic network analysis identifies physical activity-associated protein modules potentially mediating type 2 diabetes risk

Moderate-to-vigorous physical activity (MVPA) lowers the risk of type 2 diabetes (T2D). Identifying protein modules that mediate this association may help dissect these biological underpinnings, but they remain incompletely characterized. We studied 28,842 diabetes-free UK Bioban...

Gender Minority Stress, Testosterone, and Blood Pressure Responses to Stress in Transgender and Nonbinary Adults

Trans and nonbinary adults assigned female at birth (TNBF) are at elevated cardiovascular risk, an effect proposed to occur secondary to testosterone use. However, gender minority (GM) stress may also contribute to cardiovascular risk. Therefore, we examined the relative associat...

Perceived pleasantness mediates the effects of high-arousal and emotionally complex music on pain

ABSTRACT: Music effectively reduces pain, yet the mechanisms underlying music-induced hypoalgesia remain poorly understood. We investigated how latent perceptual dimensions of music influence pain by examining both stimulus properties and subjective evaluations of those propertie...

BetaII-spectrin gaps and patches emerge from the patterned assembly of the actin/spectrin membrane skeleton in human motor neuron axons

The actin/spectrin membrane-associated periodic skeleton (MPS) is a cytoskeletal structure that supports axonal integrity and function. Lower spinal motor neurons (MNs) are characterized by exceptionally long axons and are particularly susceptible to degeneration in a wide range...

Platform-Independent Suspect Screening Analysis of Pesticides and Transformation Products in Honey Bees across Multiple High-Resolution Mass Spectrometers

Abstract When investigating honey bee suspected poisoning events, traditional targeted methods may overlook relevant compounds. Thus, a suspect screening workflow combining two complementary and platform-independent strategies in parallel, an exact mass screening tool and a combi...

Electoral results affect beliefs about the past: Evidence from Chile

Can electoral outcomes shape voters' perceptions of the past? We argue that electoral outcomes provide informational cues that prompt voters to reinterpret prior conditions, shifting the benchmarks on which accountability rests. We focus on perceptions of crime, a valence issue t...

Contemporary Fibrotic Interstitial Lung Disease Outcomes: A Multicentre National Cohort Study

ABSTRACT Background and Objective This study determined contemporary transplant‐free survival in fibrotic interstitial lung disease (ILD), identified baseline factors associated with death or transplant, and assessed performance of the ILD‐GAP (Gender, Age, Physiology) index in a...

Melt Electrospinning of Poly(ε-caprolactone)/Poly(ethylene oxide)/Poly(ethylene glycol) Blend: Effects on Structure and Cellular Compatibility

Abstract This work aims to investigate the effects of the melt electrospinning process on the properties of ternary blend poly(ε-caprolactone)/poly(ethylene oxide)/poly(ethylene glycol) (PCL/PEO/PEG) fibers. The utterly different morphology of the specimens before and after melt...

Diabetes and Driving: How Predictive Technologies Will Alter Ethical and Legal Responsibilities

In 2023, a 67-year-old man with long-standing type 1 diabetes experienced a severe hypoglycemic episode and drove into an outdoor dining area in Victoria, Australia, killing 5 people and injuring several others. Although the charges against the driver were dismissed, future cases...

Advancements and challenges in lithium–oxygen battery technology: A comprehensive overview

Lithium–oxygen (Li–O₂) batteries are attractive beyond-lithium-ion systems because oxygen is stored outside the positive electrode and the Li₂O₂-forming reaction provides a theoretical specific energy of approximately 3500 Wh kg⁻¹ when oxygen is excluded from the carried mass. Th...

Comprehensive Treatment and Monthly 2 Year Follow-Up in Children With ADHD: Randomized Controlled Prospective Study

ObjectivesTo evaluate the efficacy of regular monthly follow up in maintaining treatment gains versus follow up as needed in the community for children ages 6 to 12 years with ADHD.MethodsOne hundred and eighty six children, age 6 to 13 with DSM-IV diagnosed Attention Deficit Hyp...