McGill University

Identifying Cardiac Autoantibody Biomarkers that Predict the Severity of Chagas Cardiomyopathy

Chagas cardiomyopathy (ChCM) affects up to 30% of patients with chronic Chagas disease and lacks reliable biomarkers for severity and conduction abnormalities. We profiled cardiac autoantibodies using 2-dimensional gel electrophoresis and mass spectrometry, followed by enzyme-lin...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Community views of factors influencing participation in dengue research: Fuzzy cognitive mapping in Dhaka, Bangladesh

Background Bangladesh is among the countries most affected by dengue, the fastest spreading vector-borne disease worldwide. Engaging communities in designing and implementing solutions is a promising strategy for dengue control. However, collaborating with communities in urban se...

Impact of Primary Health Care Reforms in Quebec’s Health Care System: A Systematic Review

Introduction: Primary health care (PHC) reforms in Quebec between 2000 and 2023 aimed to improve accessibility, continuity, efficiency, and equity through organisational transformation, notably the Family Medicine Groups (FMGs), centralised waiting lists (Guichets d’accès), the a...

Prefabrication of structural walls from large mineral rubble

Abstract This paper presents a new, low-carbon prefabrication process for load-bearing structural walls. It reuses large flat concrete and stone rubble sourced from demolition waste, is readily scalable, and operates under controlled factory conditions, combining the structural l...

4th Downs Decoded: A Selection-Bias-Adjusted Study of Player Impact on Fourth Down Conversions in the NFL

This research breaks down fourth downs in the NFL by identifying crucial player positions and evaluating how coaches incorporate different factors in their decision-making process. Using a newly engineered dataset that includes detailed player statistics 1 from 2017–2023, we anal...

Profiling peripheral immune cells in Parkinson's disease: A scoping review

Parkinson's disease (PD) is increasingly recognized as a multi-system disorder with immune dysregulation extending beyond the central nervous system. Although numerous studies have examined peripheral immune alterations in people with PD, findings remain heterogeneous and difficu...

Production and Characterization of β-Cyclodextrin Inclusion Complexes Containing Conjugated Linoleic Acid from Njangsa (Ricinodendron heudelotii) Seed Oil

Njangsa seed oil (NSO) is rich in polyunsaturated fatty acids and represents an underexplored plant source for producing conjugated linoleic acid (CLA). This study explored the production of CLA from NSO via alkali isomerization, as well as and its stabilization by β-cyclodextrin...

PTPN2 sustains non-canonical inflammasome activation and shapes the inflammatory response to sepsis

Abstract The innate immune system relies on pattern recognition receptors to recognize and detect pathogens. Gram-negative bacteria release LPS-rich outer membrane vesicles (LPS-OMVs), which activate PRRs, trigger inflammation at distant sites and contribute to systemic inflammat...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Multivariate analysis identifies distinct latent components and highlights the contribution of motor cortex neurochemistry to clinical variance in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is marked by substantial clinical heterogeneity across motor and extramotor domains, yet how different neuroimaging modalities jointly relate to this heterogeneity remains poorly understood. Prior ALS neuroimaging studies have largely...

From pathogenesis to non-medical therapy: A review of exploring sensory and multi-sensory stimulation as a non-invasive treatment approach for Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, marked by the accumulation of amyloid-beta plaques, tau pathology, and synaptic dysfunction, ultimately leading to memory loss, cognitive decline, neuropsychiatric symptoms and neuronal degeneration that impair...

Overcoming Intra-Articular Delivery Barriers in Cartilage Regeneration: Emerging Controlled-Release Strategies

Articular cartilage has a limited capacity for self-repair due to its avascular nature, dense extracellular matrix, and low cellularity. Current treatments for cartilage injury and osteoarthritis (OA) often provide temporary symptom relief but do not restore native tissue structu...

Cross-cultural adaptation of the Athlete Diet Index, a web-based dietary assessment tool for athletes

Background The literature suggests that many athletes fail to meet health and sport-specific dietary recommendations which may negatively impact their overall health and performance. Moreover, completing a proper assessment of an athlete's diet is complex; the quality and validit...

A map of RBP-miRNA regulatory connections for deciphering the mechanisms of transcriptome remodeling in cancer

Micro-RNAs (miRNAs) are key post-transcriptional regulators of gene expression that influence cancer progression and outcome. Whereas transcriptional dysregulation of miRNA abundance underlies abnormal functionality of some miRNAs in cancer, emerging data points to RNA-binding pr...

The clock gene cycle synchronizes circadian metabolic oscillations uniquely in reproductively active Culex pipiens females

Abstract The circadian clock regulates changes in daily metabolite abundance, coordinating animal activity, feeding and rest. The Northern house mosquito, Culex pipiens , also displays seasonal changes between periods of reproductive activity and overwintering diapause, regulated...

Treatment of male osteoporosis: a narrative review and position statement by the ECTS Clinical Action Group.

Osteoporosis in men is under-recognized and under-treated despite a substantial disease burden and poorer fracture-related outcomes than in women. Secondary osteoporosis is highly prevalent in men, making the identification and management of underlying causes essential. Bone mine...

Rapid estimation of structural brain disconnection from binary lesion masks using DeepDisco

Abstract Mapping how focal brain lesions disrupt structural connectivity is key to understanding cognition, behavior, and neurological outcomes. However, traditional diffusion tractography pipelines are computationally intensive, require specialized data and expertise, and remain...

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Semantic Completeness for Correct Maintenance: A Strict Hierarchy of Typing and Inheritance

Correct maintenance keeps required answers, excludes invalid states, and minimizes separately supplied answers and lifetime semantic edits (changes to required answers) across mechanisms. Banning semantic completeness makes correct maintenance formally impossible. We give exact m...