McGill University

ATAD2 is a novel regulator of myogenesis and autophagy in skeletal muscles

Abstract The nuclear protein ATAD2 (ATPase family AAA domain containing 2) is a known positive regulator of cell proliferation in various cancer types. The expression and functional roles of ATAD2 in skeletal muscle cells are unknown. In this study, we used transient and stable k...

Biomimetic Hydrogels with Nucleus Pulposus-like Viscoelasticity and ECM Peptides for Discogenic Differentiation of Stem Cells

Abstract Intervertebral disc (IVD) degeneration is a leading cause of low back pain (LBP), primarily originating in the nucleus pulposus (NP). Regenerative strategies combining mesenchymal stem cells (MSCs) with biomaterials offer great potential for NP repair by replenishing cel...

A Narrative View of Curiosity in Organizations

How can managers be curious and incurious at the same time? This question emerged as a puzzling anomaly from interview data collected with operational managers and supervisors confronting early signals of platform-economy disruption. Rather than stable differences across responde...

ATP‐Mediated Bidirectional Communication Between Natural and Artificial Cells for Controlled Bioreactions

ABSTRACT Communication between living and artificial cells represents a fundamental step toward constructing hybrid systems capable of cooperative behaviors. Here, we introduce an ATP‐mediated energy transduction mechanism that enables bidirectional communication between natural...

Comparative genomic analysis reveals distinct population structure in Legionella anisa

Abstract Legionella anisa has been frequently isolated from engineered water systems; however, its population structure remains understudied compared to Legionella pneumophila. Here, we generated complete genome sequences for four L. anisa isolates recovered from a healthcare fac...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...

Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC

Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a...

Grass Expression Atlas: an RNA-seq-based expression resource for grass species

Abstract Grass Expression Atlas (GExA) is an interactive web-based resource for rapid exploration of gene expression across diverse tissues, developmental stages, and conditions in grass species. GExA integrates publicly available RNA sequencing (RNA-seq) datasets for four millet...

Uncovering scleromyositis: no myth, just missed

Purpose of review Scleromyositis (SM), the muscle-specific manifestation of scleroderma, is increasingly recognized as a distinct myositis subset, yet it remains poorly captured by existing classification criteria and absent from therapeutic guidelines. This review provides recen...

Dietary Fat Intake and Mortality Among Patients With Nonmetastatic Prostate Cancer

Importance There are 3.5 million prostate cancer survivors in the US, with a need for evidence-based lifestyle recommendations that improve survivorship. Objective To assess whether consumption of specific dietary fats after diagnosis is associated with long-term survival among p...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

On variability in local field potentials

Abstract Neuronal coding and decoding would be compromised if neuronal responses were highly variable. Intriguingly, neuronal spike counts (SCs) show a reduction in across-trial variance (ATV) in response to sensory stimulation, when SC variance is normalized by SC mean, that is,...

Measuring what matters: a rasch-validated instrument for functional sexual and reproductive health literacy among Ghanaian adolescents

Abstract Background Functional sexual and reproductive health (SRH) literacy is fundamental to informed decision-making among adolescents. Yet existing measures hardly address the needs of low-literate populations in Sub-Saharan Africa. This study developed and validated a test o...

Development and validation of the personal recovery scale (ReConnect) for mental health in Ethiopia

Background: Socio-cultural context is crucial for conceptualising personal recovery in mental health, but existing measures are from Western, high-income countries. Aim: To develop and validate a mental health personal recovery measure for people with mental health conditions in...

Lack of Efficacy of Low‐Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double‐Blind Placebo‐Controlled Clinical Trial

Sleep bruxism (SB) is a motor activity characterized by repetitive masticatory muscle contractions during sleep, commonly associated with tooth damage and jaw pain or headache. Pharmacological management strategies targeting its central nervous system-related mechanisms remain li...

The Art of Printing [3D Engineering & Advanced Geometry]

There are sequences of actions that we repeat everyday. Among them is the printing action: print a numeric paper in pdf format and save it on your computer, or print it using a Xerox Machine or HP-printer. We found out we can do More: Let us Print in 3D Dimension, and investigate...

Bladder cancer precision-cut tumor slices (PCTS) preserve functional immune microenvironment enabling ex vivo drug evaluation

Abstract Background The development of effective cancer immunotherapies is hindered by the lack of preclinical models that faithfully preserve tumor-immune interactions. Current approaches provide limited representation of immune components, creating a critical translational gap...

Neural mechanisms underlying the sensory and sensorimotor learning of birdsong

Communication is a natural social behavior that influences reproduction and survival; consequently, central questions in neuroethology involve discovering how activity in distinct neural populations regulates the performance, perception, and development of communication signals....

Nonlinear cyclic response of U-shaped flexural plates under quasi-static wind loading protocols: An experimental investigation

U-shaped flexural plates (UFPs) made from rolled mild steel are widely used in seismic force-resisting systems (SFRSs) as replaceable energy-dissipating components. While their seismic performance is well documented, recent advancements in performance-based wind design (PBWD) req...

Baseline gut microbiome and metabolome profiles predict weight loss after a structured lifestyle intervention

Abstract Background Obesity remains a global health challenge, and responses to lifestyle-based weight-loss interventions are heterogeneous. Here, we evaluate a one-year structured lifestyle program in 50 adults with obesity (mean BMI 42 ± 7.0 kg/m 2 ), integrating clinical, micr...