McGill University

Sex differences in mortality risk profiles across the life course in metabolic dysfunction-associated steatotic liver disease: a machine learning analysis of the Canadian Longitudinal Study on Aging

Abstract Background Prognostic models for metabolic dysfunction-associated steatotic liver disease (MASLD) are largely ‘one-size-fits-all’ and do not collectively account for sex differences and social determinants of health (SDoH). To address this gap, we trained and developed s...

Sexually dimorphic control of excitatory synapse maintenance in ventral hippocampal circuits by Neurexin2α ligand Vstm2b

Abstract Neuronal networks rely on precise synapse formation, maturation, and maintenance orchestrated by synaptic adhesion molecules including α- and β-neurexins (Nrxns). Through unbiased proteomics, we identified Vstm2 family members as α-Nrxn-specific interactors that require...

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Lake size is associated with the relationship between body mass and gut microbiota alpha diversity in threespine stickleback (Gasterosteus aculeatus)

Lake size is associated with ecological conditions that can affect the microbiome of hosts, such as diet and habitat characteristics. However, whether host-microbe interactions are affected by lake size remains poorly understood. We characterized the gut microbiota of 191 wild th...

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

A new albertosaurine from the Oldman Formation, Alberta, Canada, illuminates ambiguity between albertosaurine and tyrannosaurine characteristics

Tyrannosaurid species have often been considered to have high longevity and low diversity relative to contemporaneous megaherbivores. Recent chronospecies assertions around tyrannosaurid lineage evolution have reinforced this idea. An albertosaurine, Tromerosaurus solumons, from...

Interpretable and Calibrated Classification of Clinical Data Using Supervised Feature Binarization

Black-box models limit the adoption of artificial intelligence in medicine because their predictions are difficult to interpret and reproduce. We present a statistically grounded framework for interpretable, rule-based clinical classification using the Bernoulli Naïve Bayes (BNB)...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

Mind the Gap: Disparities in Education on Organ Donation and Transplantation-Results of a Global Survey.

Background: Widely accessible education on organ donation and transplantation (ODT) is a tool to reduce waiting lists, as <10% of transplant needs are met (Global Observatory on Donation and Transplantation). We aimed to assess the current state of access to education on ODT worl...

A Contemporary Review of Resectability and Treatment Strategies for Colorectal Liver Metastases: Part 1—Diagnosis, Defining Resectability, and Management of Upfront Resectable and Synchronous Disease

Background/Objectives: Colorectal liver metastases (CRLMs) remain a major determinant of long-term outcome. Although hepatic resection offers the best chance of durable survival, the definition of resectability has evolved beyond technical feasibility alone. This review aims to p...

Checked-In Secret Detection: Strings Are All You Need

Hardcoded secrets in source code pose critical security vulnerabilities which can be easily exploited by malicious adversaries. Existing regex-based detection approaches suffer from fundamental limitations, as secrets often lack identifiable patterns, resulting in poor precision...

Generalized Nonlinear Bayesian Pulsar Timing with ENTERPRISE

Abstract We use the Bayesian methods in the ENTERPRISE package to examine the fully general parameterization of pulsar timing models in tandem with noise. We investigate four pulsars, PSRs J1600–3053, J2043+1711, J0740+6620, and J1640+2224, through the lens of Bayesian timing. We...

Reduced Longwave Absorption of Magnesium Sulfate Aerosol as an Alternative to Sulfuric Acid for Stratospheric Aerosol Injection

Abstract Aqueous sulfuric acid is the benchmark sulfate aerosol for stratospheric aerosol injection (SAI), but /O aerosol absorbs strongly in the infrared, producing longwave warming that significantly offsets its shortwave cooling. Here, we evaluate magnesium sulfate () as a non...

Semantic Completeness for Correct Maintenance: A Strict Hierarchy of Typing and Inheritance

Correct maintenance preserves required answers, excludes invalid states, and minimizes lifetime semantic edits. Banning semantic completeness makes it impossible. We prove necessary conditions for this optimum: a strict hierarchy with exact minima for identity names, contract mem...

Trauma-Focused Therapy in Sexual and Gender Minority Individuals: A Scoping Review of Therapeutic Interventions Contributing to Accessibility and Outcomes

Rates of trauma exposure and post-traumatic stress disorder (PTSD) are much higher in sexual and gender minorities (SGMs). However, negative psychotherapy experiences are frequently reported in this population. There is limited existing literature on outcomes for SGMs in trauma-f...

Bayesian power spectrum estimation with modelling of systematic effects in delay-fringe rate space

Abstract Observing the Epoch of Reionisation using 21cm radio interferometry has proven to be a challenging task. Extraction of the extremely faint redshifted signal is complicated by the presence of bright foregrounds, radio frequency interference (RFI), and systematic artefacts...

Comprehensive profiling of brain dynamics during anesthesia across phylogeny

Abstract The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, ze...

Repeated exposure to viral and bacterial danger signals in Parkin deficient mice induces inflammation but fails to trigger parkinsonism

Experimental models of Parkinson's disease (PD) traditionally involve direct perturbations of the functioning of dopamine (DA) neurons. However, PD is increasingly recognized as multifactorial in origin and involving both cell-autonomous vulnerability factors and non-cell-autonom...