McGill University

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

Improving FolateBioaccessibility and Modulating GutMicrobiota Profile with Folate-Enriched Purple Cabbage Juice by Optimized Lactiplantibacillus plantarum Fermentation

Abstract Folate biofortification of plant-based foods via lactic acid bacteria fermentation is a strategy to alleviate folate deficiency; however, the effects of fermentation on folate stability and bioaccessibility remain unclear. In this study, purple cabbage juice was fermente...

Timing of cognitive decline onset and life-course trajectories A pooled longitudinal analysis of 14,389 adults across three cohorts

Background Population ageing is driving a global surge in cognitive impairment. While late-life decline is well-characterized, the onset of measurable cognitive changes across the full adult lifespan remains uncertain. We aimed to estimate the age at which detectable decline begi...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...

OvercomingElectrochemiluminescence Immunoassay (ECLIA)Limitations: Conformation-Independent Quantitation of a TherapeuticAntibody by LC–MS/MS

Abstract Monoclonal antibody therapies have transformed cancer treatment by enabling targeted intervention even in advanced disease stages. However, reliable monitoring of circulating therapeutic antibody levels is critical to ensuring efficacy and patient safety. This study inve...

Distributed burst firing mediates optimized cortical encoding of natural self-motion

Accurate perception of self-motion requires that vestibular input be transformed into neural representations suitable for integrating multisensory cues to guide action. Here, we demonstrate that vestibular cortical neurons represent the self-motion stimuli encountered during ever...

TEExplorer: a web portal to investigate TE-epigenome associations across human cell types

Approximately half of the human genome is derived from transposable elements (TEs) and several studies support the involvement of TEs in genome regulation in development, immunity and disease. We previously leveraged 4614 ChIP-seq samples from the International Human Epigenome Co...

Benzohydroxamic Acid as a Collector for Flotation of Chrysocolla: Mechanistic Insights and Bench-Scale Performance

Chrysocolla, a hydrated copper silicate mineral, is notoriously difficult to recover by conventional froth flotation due to its microporous structure, low hydrophobicity, impurity substitutions, and poor response to traditional collectors. This study evaluates the performance and...

A transposon-derived transcription factor senses ionic stress through phase separation to govern plant autophagy

Salt stress severely impairs plant growth through two distinct cellular insults: osmotic stress caused by water limitation and ionic toxicity resulting from excessive Na + accumulation. Although plant osmosensors have been identified, the mechanisms underlying ionic stress percep...

Linking Magmatism and Gold Mineralization at the Fenelon Gold Deposit, Northern Abitibi, Canada: Insights from Pyrite Chemistry, U-Pb and Re-Os Geochronology

Abstract The Fenelon gold deposit, located in the underexplored northern region of the Abitibi greenstone belt, hosts an estimated 4.09 Moz at 3.20 g/t Au and is spatially associated with the 2697 ± 0.96 Ma Jeremie diorite (isotope dilution-thermal ionization mass spectrometry [I...

Biracial Emerging Adults’ Phenotype and Multiracial Pride Predicting Academic Achievement via Discrimination Experiences

The current study examined how Biracial emerging adults’ phenotype and Multiracial pride were associated with racial discrimination and, in turn, GPA. Participants were 378 Biracial emerging adults. Results indicated that there were gender differences. Among women, Multiracial pr...

More than SAM: mechanisms of action of the Polycomb group protein polyhomeotic

The Polycomb Group (PcG) system controls developmental transitions and cell states across species. Two main PcG complexes, Polycomb Repressive Complexes 1 and 2 (PRC1, PRC2), regulate transcription and form epigenetic memory through chromatin. Polyhomeotic (Ph) is an essential PR...

A Scoping Review on the Evidence for Virtual Reality Simulation in Surgical Training

Objective Simulation has become a mainstay in surgical education as it is proven to improve trainees’ surgical skills. Virtual reality is a relatively new technology that allows for high-fidelity surgical simulation for many surgical procedures across many specialties. However, t...

Housing opacity in North America and beyond: a feasibility study

The availability and access to rental ownership data have become a growing topic of interest among academics, housing organisations, policy makers, and advocacy groups. It is increasingly obvious that data infrastructures play a big role in facilitating the access, workability, a...

Collaboratively building teaching resources for EDI in epidemiology and biostatistics

Abstract Objectives The objective of this workshop was to collaboratively co-create concrete, practical teaching resources that embed equity, diversity, and inclusion (EDI) concepts into epidemiology and biostatistics teaching in Canada. Methods The 3-h interactive session develo...

A qualitative study on how and why families engage with diverse antenatal care systems in rural eastern Zimbabwe

Antenatal care (ANC) pluralism—meaning, pregnancy-related care and support drawing on local indigenous and biomedical forms of care—is essential to reducing pregnancy-related morbidity and mortality in culturally appropriate ways in sub-Saharan Africa. Yet, many current intervent...

Women’s experiences of intuitive exercise: A reflexive thematic analysis

This study sought to deepen understandings of intuitive exercise among women navigating physical activity contexts that reinforce societal gendered messages and norms about bodies and exercise, promote dysfunctional exercise attitudes and behaviours, and undermine sustained parti...

Exploring Training Needs to Facilitate Shared Decision Making in Juvenile Idiopathic Arthritis Symptom Management and the Use of the JIA Option Map

Objectives Our team developed the JIA Option Map, a web-based patient decision aid (PDA) designed to support shared decision-making (SDM) for juvenile idiopathic arthritis (JIA) symptom management. Since training for health care providers (HCP) can enhance SDM and the use of PDAs...

Exploring Decisional Factors to Include Approaches in a Patient Decision Aid for Juvenile Idiopathic Arthritis Symptom Management

Objectives Youth with juvenile idiopathic arthritis (JIA) experience physical and mental health symptoms that negatively impact their participation in daily life activities. The JIA Option Map is a web-based patient decision aid (PDA) created to facilitate decision-making for JIA...

Mortality in ANCA-Associated Vasculitis: A Retrospective Study from a Tertiary Vasculitis Center

Objectives Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), comprising granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), remains a life-threatening disease despite therapeutic advances.[1] Although immunosuppressive treatments have...