McGill University

The CNNM-binding interface drives PRL-3-dependent tumor progression in de novo cancer models

Phosphatase of regenerating liver 3 (PRL-3) is a cancer-associated protein linked to tumor progression, metastasis, and poor patient outcomes, but the mechanism underlying its oncogenic activity remains unresolved. PRL-3 functions both as a phosphatase and as a binding partner of...

Stretchable electroluminescent devices based on microLEDs: materials, fabrication, system design, and applications

Micro-light-emitting diodes (microLEDs) have emerged as one of the most promising emitters for stretchable electroluminescent (EL) devices owing to their high brightness, efficiency, operational stability, and environmental robustness. This review summarizes recent advances in mi...

Plasma proteome reflects tissue damage and clinical manifestations in patients with inflammatory myopathies

OBJECTIVE: Tissue-specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating cle...

Group Sequential Design with Posterior and Posterior Predictive Probabilities

Group sequential designs drive innovation in clinical, industrial, and corporate settings. Early stopping for failure in sequential designs conserves experimental resources, whereas early stopping for success accelerates access to improved interventions. Bayesian decision procedu...

Antioxidant mechanisms and green extraction of cranberry-derived polyphenols

Antioxidant-rich natural compounds have received major research interest over synthetic antioxidants and preservatives. Cranberry ( Vaccinium macrocarpon Ait. ) has attracted the food industry’s attention for its bioactive qualities and for its clinically assessed beneficial impa...

Pharmacokinetics of phosphodiesterase type 5 inhibitors and β-adrenergic receptor type 3 agonists for benign prostatic hyperplasia

Introduction Benign prostatic hyperplasia (BPH) is amongst the most common conditions affecting aging men, with resulting lower urinary tract symptoms (LUTS) impeding on quality of life. While many medication classes exist for treatment of LUTS secondary to BPH, their increasing...

Understanding the resistance to trauma-informed care: The emotional, relational and ideological challenges of shifting power dynamics in child and youth residential care

BACKGROUND: Trauma-informed care (TIC) is a relational approach emphasizing safety, attunement, and collaboration. In child and youth residential care, this orientation sits in tension with longstanding compliance-oriented approaches that rely on rigid systems of incentives and c...

Species-specific prophage induction by ciprofloxacin in human gut metagenomes

ABSTRACT Antibiotics are known to trigger prophage induction in controlled laboratory settings, but it remains unclear whether this also occurs within microbiomes in nature. Current methods investigating the link between antibiotics and prophage induction within the human gut rel...

Deep reinforcement learning for optimizing mobile depots allocation and hybrid order dispatch in last-mile delivery under multi-participants behavioral uncertainty

As last-mile delivery demand continues to grow and customer preferences become increasingly diverse, traditional single-mode logistics systems are inadequate in addressing the complexity and variability of modern urban delivery environments. In this paper, we propose an innovativ...

Hybridizing sisters: Evidence of bluegill-pumpkinseed hybridization in modified habitats at the confluence of two major Canadian waterways

Urbanization and shoreline development are reshaping aquatic ecosystems, creating conditions that promote hybridization among fishes. This study investigates the potential hybridization between bluegill (Lepomis macrochirus) and pumpkinseed (Lepomis gibbosus) at the confluence of...

Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion

Despite advances in delineating the molecular diversity and projection patterns of midbrain dopamine (DA) neurons, subtype-specific contributions to motor learning and movement execution remain poorly defined. Here, we applied intersectional ablation and inhibitory chemogenetics...

Stratospheric Temperature Adjustment Robustly Damps the State Dependence of CO 2 Radiative Forcing

Abstract The equilibrium climate sensitivity (ECS) depends on background climate state, a phenomenon known as state dependence. Recent studies highlighted state‐dependent CO 2 radiative forcing as a mechanism for ECS state dependence, largely attributing it to enhanced instantane...

Osteosarcopenia Revisited: From Mechanisms to Management

Abstract Sarcopenia and osteoporosis are characterized by insufficient mass and function of skeletal muscle and bone, and often co-occur in older persons, a condition called osteosarcopenia. Loss of bone and skeletal muscle mass and function is driven by multiple risk factors tha...

P1.085. Real-World Outcomes of Double Checkpoint Inhibition for MSI-H Gastroesophageal Adenocarcinoma

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Gastroesophageal Adenocarcinoma (GEA) is a leading cause of cancer worldwide, with up to 10% of cases harbouring microsatellite instability (MSI-H) characterized by mutations in mismatch-repair prote...

P1.111. The Presence of Signet Ring Cells Predicts Aggressive Chemotherapy Resistance in Esophageal Adenocarcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Esophageal adenocarcinoma (EAC) remains a rapidly rising and poorly controlled malignancy worldwide, despite radical surgery and multimodal therapy. Signet ring cells (SRC) are classically known to signal a...

P1.243. Bi-Cavity Esophagectomy With Supra-Aortic Reconstruction (BEAR): A Novel Approach to Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Due to its reduced incisional burden minimally-invasive Ivor Lewis esophagectomy (MIE) is an emerging standard of care, though it remains a long operation with high morbidity. Left th...

Time-surrogate variables enhance the association between cardiotocographic features and intrapartum hypoxic-ischemic encephalopathy

Abstract Background Interruptions to the flow of oxygenated blood to the fetal brain during labor can lead to hypoxic-ischemic encephalopathy (HIE). Timely preventive interventions for suspected hypoxemia are crucial to avoid progression to neurological injury. Prior research has...

Equivalent Numeric Approved Identity of Passport and Immigration Papers -- The Next Generation Identification Program (NGI) [A Short Introduction]

We express an interest to Equivalent Numeric Approved Identity of Passport and Immigration Papers. [We are making a submission to the Journal of Banking and Financial Technology].

A Data-Efficient Deep Learning Paradigm for Crack Segmentation Using Generative AI

High manual annotation costs and poor generalizability often limit the robustness of deep learning models for pavement crack segmentation. This study addresses these challenges by developing and validating a diffusion-based generative artificial intelligence framework to support...

Latent gene network expression underlies partial re-evolution of a polyphenic trait in the worker caste of ants

Polyphenisms–where alternative phenotypes develop from a single genome in response to environmental cues–are not only widespread in nature, but also occur at multiple levels of biological organization, from cells to individuals to societies. Polyphenism is thought to promote phen...