Institution
McGill University
Recent research
- Health & MedicineOpen access
To develop and validate a biomarker-anchored probabilistic principal component analysis (PPCA) framework for identifying biologically interpretable latent dimensions of Alzheimer’s disease (AD) and evaluating their utility for disease progression modeling. Data from 1058 particip...
- Health & MedicineOpen access
Tau, a neuronal microtubule-associated protein (MAP), organizes the axonal cytoskeleton, and regulates intracellular transport. Tau hyperphosphorylation is linked to neurodegeneration in tauopathies, including Alzheimer’s disease. Tau binds microtubules cooperatively to form cohe...
- BiologyOpen access
ClpP protease maintains proteostasis in human mitochondria and is overexpressed in cancers such as acute myeloid leukemia (AML). While activators such as dordaviprone (ONC201) have reached the clinic, the development of ClpP inhibitors has been hampered by paradoxical activation...
- Health & Medicine
Abstract In patients with cystic fibrosis, nontuberculous mycobacteria are opportunistic, intracellular and extracellular pulmonary pathogens that contribute to deterioration of lung function and, ultimately, morbidity from respiratory failure. Among nontuberculous mycobacterial...
- BiologyOpen access
ABSTRACT Ductal carcinoma in situ (DCIS) is a non‐invasive precursor of invasive ductal carcinoma (IDC), yet the biological mechanisms underlying the transition from DCIS to IDC remain incompletely understood. Here, we integrate spatial transcriptomics, single‐cell RNA sequencing...
- Physics & SpaceOpen access
This deposit presents a geometric framework in which general relativity and quantum mechanics are unified as projections of a single classical sixteen-dimensional geometry, and in which gravity and the gauge interactions are unified structurally as index-blocks of one metric. The...
- Climate & EnvironmentOpen access
Aerosol particles contain complex mixtures of polar and non-polar species that can undergo organic-inorganic phase separation. In phase-separated aerosol particles, the phase state of the outer organic coating can modulate heterogeneous chemistry. Heterogeneous chemistry leading...
- Health & MedicineOpen access
Association Between Genetic Ancestry and Multiple Sclerosis Severity
OBJECTIVE: The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). METHODS: Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyp...
- Health & MedicineOpen access
Heparan sulfate (HS) a glycosaminoglycan family of carbohydrates, is covalently attached to core proteins forming heparan sulfate proteoglycans (HSPGs) which are found on the surface of cells. Following endocytosis, HSPGs are degraded within lysosomes by several enzymes, includin...
- AI & ComputingOpen access
We have started an Application into The Dalhousie University English Program. We notice for the first time a very intelligent information system. Some documents that we did save in our Google Drive Account [but not published elsewhere*] have contributive value in the system. As f...
- Health & MedicineOpen access
Non-invasive assessment of left atrial activation using lead V8 during Bachmann bundle pacing
Abstract Background and aims Bachmann bundle pacing (BBP) improves atrial synchrony by advancing LA activation, but quantifying inter-atrial synchronization remains challenging. This study evaluated whether lead V8 reflects posterolateral LA activation time and whether lead V8 ca...
- Physics & SpaceOpen access
Designing a buildable optimised stellarator to confine electron–positron plasmas
In this paper, the design of the plasma equilibrium and superconducting coils for the electrons and positrons in an optimised stellarator electrons and positrons in an optimized stellarator (EPOS), experiment is presented. With newly developed stellarator optimisation tools, incl...
- Climate & EnvironmentOpen access
Abstract The Breede River in the Western Cape Province is one of South Africa’s major freshwater systems and of high ecological and socio-economic value. Similar to other freshwater systems worldwide, it is threatened by environmental degradation and multiple invasive species. Un...
- AI & ComputingOpen access
Open source software (OSS) often prioritizes technical functionality over usability and UX design. This imbalance limits OSS adoption among broader, non-technical users. Key underlying factors contributing to this issue are the shortage of design expertise in OSS and a dominant d...
- Climate & EnvironmentOpen access
Foreword: Isolated, yet connected
Guest editor Uğurgül Tunç explores the paradoxical pasts, presents, and futures of the built environment of health/care: In the 1980s, Roger Ulrich's landmark study "View through a window may influence recovery from surgery," popularized the idea that hospital rooms offering view...
- AI & ComputingOpen access
The Pearson IV distribution: random variate generation and applications
We develop uniformly fast random variate generators for the Pearson IV distribution that can be used over the entire range of both shape parameters and highlight some applications in a Bayesian setting.
- AI & Computing
Abstract. Homoclinic snaking is a widespread phenomenon observed in many pattern-forming systems. Demonstrating its occurrence in nonperturbative regimes has proven difficult, although a forcing theory has been developed based on the identification of patterned front solutions. T...
- AI & ComputingOpen access
"We Wanted to Do Better Than the Law": Exploring UI/UX Designers' Privacy Advocacy in Practice
Designers hold primary responsibility for shaping the user interface (UI) and user experience (UX) of a product. This role goes beyond aesthetics and usability, extending to the privacy outcomes of user experience, which often emerge through collaboration with other stakeholders...
- BiologyOpen access
The gene-regulatory evolution of the human skeleton
Abstract Skeletal modifications were central to human evolution, enabling adaptations for bipedalism, large cranial vaults and childbirth 1 . Despite their importance, the genetic changes that gave rise to the unique human form remain mostly unknown 2 . Here we systematically map...
- BiologyOpen access
Theta oscillations (4-12 Hz) are a prominent network rhythm within hippocampal and parahippocampal structures. Driven by cholinergic and γ-aminobutyric acidergic inputs originating from the medial septum, physiological theta gates network excitability to control spatial navigatio...