McGill University

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic...

Advancing phosphorus foliar fertilization with nano-hydroxyapatite: mechanisms and agricultural relevance

<title>Abstract</title> Phosphorus (P) use in agriculture remains inefficient and poses long-term environmental concerns. We investigate the uptake, redistribution, and efficacy of foliar-applied nano-hydroxyapatite (nHAp) in P-deficient barley (Hordeum vulgare), aiming to clarif...

Beyond the binary: a patient-centred approach to SSRIs and pregnancy

Purpose This study aims to examine the polarised discourse surrounding selective serotonin reuptake inhibitor (SSRI) use during pregnancy and to propose a human rights-based and autonomy-focused approach grounded in reproductive justice and shared decision-making. Design/methodol...

PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation

Abstract Programmed cell death protein 1 (PD-1) is expressed by T cells during progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease caused by the human-only JC polyomavirus. Why PD-1 blockade finds variable success in PML patients is unclear. Brain C...

Defining ‘psychedelic’

Humphry Osmond coined the term ‘psychedelic’ in 1956, conjoining ‘psyche’ for ‘soul’ and ‘delic’ for ‘to manifest’ or ‘illuminate’. Soul-illumination is a compound noun that describes a psychological state or process. Osmond intended for it to be a taxonomic noun—naming, not just...

Game Developments [Simulation and Convergence Scenarios]

There are tools to fastly simulate the Universe in Diverse Scenarios : among those tools, are mainly the Game Development tools. We will introduce few notes about them.

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...

Resolving Hidden Stoichiometriesin Bacterial ProteasomeActivator (Bpa)-Substrate Complexes by Cryo-EM and Charge DetectionMass Spectrometry

Abstract Bacterial proteasome activator (Bpa) is a regulatory particle within the Mycobacterium tuberculosis (Mtb) proteasome system that facilitates ATP-independent substrate engagement and delivery to the 20S core particle (CP) for degradation. The best characterized Bpa substr...

Triple potentiator combinations increase the functional correction of several CFTR gating mutants

The Trikafta drug combination, comprising the corrector tezacaftor (VX-661), the potentiator ivacaftor (VX-770) and the dual corrector/potentiator elexacaftor (VX-445), has been FDA-approved for treatment of cystic fibrosis caused by ~300 cystic fibrosis transmembrane conductance...

Affidavit of Support [SponsorShip Path]

We are grateful for the Opportunity to apply to Biola University. The platform is requesting an affidavit of Support. In the Internet Guidelines, Some Institutions can offer Affidavit of Support as SponsorShip Investments.

The practical impact of numerical variability on structural MRI measures of Parkinson’s disease

Abstract Numerical variability is rarely quantified in neuroimaging despite many measures relying on subtle morphometric differences across individuals. We instrumented FreeSurfer 7.3.1, a widely used neuroimaging pipeline, to simulate numerical differences across computational e...

Engaging primary care teams with patient-reported data: design, acceptability and outcomes of a structured intervention

Abstract Background Although patient-reported data are increasingly available and their usefulness is recognized, these measures are not well integrated at the clinical levels of primary care. Also, the processes through which these data are translated into actionable insights fo...

Introducing Mid‐Level Dental Providers in Iran: Challenges and Opportunities

ABSTRACT Objectives The WHO Global Strategy and Action Plan on Oral Health 2023–2030 encourages innovative approaches such as shifting tasks from dentists to Mid‐level Dental Providers (MLDPs), who work independently to improve access to and equity in oral health. This study aime...

Platform ecosystem governance and its influence on the process of formation and institutionalization of new practices for development

This study examined how platform ecosystem governance mechanisms, as enacted through human intermediaries, influenced the formation and institutionalization of new practices among smallholder farmers in an ICT4D context. We conceptualize platform ecosystems as socio-technical sys...

Skills to build the nation: immigrant labour market and Canadian nationalism

In Skills to Build the Nation, Chatterjee argues that the postwar focus in Canadian immigration and integration policies on skill (and, relatedly, Canadian experience) is not instrumental but the l...

A General Approach for Estimating Projective IRT Models

Projective Item Response Theory (PIRT) modeling is a measurement framework in which multidimensional item response models are expressed in terms of lower-dimensional (e.g., unidimensional) proxy IRT models. Existing PIRT methods and their associated estimators currently rely on l...

The Metabolic Revolution in Dermatology: Obesity, Insulin Resistance, and Ultra-Processed Diets as Drivers of Skin Inflammation

Inflammatory dermatoses are increasingly linked to systemic metabolic factors. Obesity and insulin resistance create a pro-inflammatory milieu that affects the skin. Adipose tissue functions as an endocrine organ secreting adipokines and cytokines that drive chronic inflammation...

Statistical methods, outcome structures, and research designs in hybrid type II effectiveness-implementation studies: protocol for a scoping review

<ns5:p>Background Hybrid type II effectiveness-implementation studies evaluate health intervention and implementation strategy effectiveness simultaneously. While the emphasis on each “side” varies within hybrid type II studies, the focus of this review is those that attempt a mo...

Spatial exclusion on public land: Fragmented governance and Vancouver's golf courses

Cities face growing pressure to justify how scarce urban land is allocated and whose needs it serves. This article analyzes spatial exclusion in Vancouver, British Columbia, a Canadian city under housing and land-use pressure. The analysis centers on municipal golf courses as an...