McGill University

P1.085. Real-World Outcomes of Double Checkpoint Inhibition for MSI-H Gastroesophageal Adenocarcinoma

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Gastroesophageal Adenocarcinoma (GEA) is a leading cause of cancer worldwide, with up to 10% of cases harbouring microsatellite instability (MSI-H) characterized by mutations in mismatch-repair prote...

P1.243. Bi-Cavity Esophagectomy With Supra-Aortic Reconstruction (BEAR): A Novel Approach to Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Due to its reduced incisional burden minimally-invasive Ivor Lewis esophagectomy (MIE) is an emerging standard of care, though it remains a long operation with high morbidity. Left th...

P1.111. The Presence of Signet Ring Cells Predicts Aggressive Chemotherapy Resistance in Esophageal Adenocarcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Esophageal adenocarcinoma (EAC) remains a rapidly rising and poorly controlled malignancy worldwide, despite radical surgery and multimodal therapy. Signet ring cells (SRC) are classically known to signal a...

Osteosarcopenia Revisited: From Mechanisms to Management

Abstract Sarcopenia and osteoporosis are characterized by insufficient mass and function of skeletal muscle and bone, and often co-occur in older persons, a condition called osteosarcopenia. Loss of bone and skeletal muscle mass and function is driven by multiple risk factors tha...

Time-surrogate variables enhance the association between cardiotocographic features and intrapartum hypoxic-ischemic encephalopathy

Abstract Background Interruptions to the flow of oxygenated blood to the fetal brain during labor can lead to hypoxic-ischemic encephalopathy (HIE). Timely preventive interventions for suspected hypoxemia are crucial to avoid progression to neurological injury. Prior research has...

A Data-Efficient Deep Learning Paradigm for Crack Segmentation Using Generative AI

High manual annotation costs and poor generalizability often limit the robustness of deep learning models for pavement crack segmentation. This study addresses these challenges by developing and validating a diffusion-based generative artificial intelligence framework to support...

Latent gene network expression underlies partial re-evolution of a polyphenic trait in the worker caste of ants

Polyphenisms–where alternative phenotypes develop from a single genome in response to environmental cues–are not only widespread in nature, but also occur at multiple levels of biological organization, from cells to individuals to societies. Polyphenism is thought to promote phen...

Equivalent Numeric Approved Identity of Passport and Immigration Papers -- The Next Generation Identification Program (NGI) [A Short Introduction]

We express an interest to Equivalent Numeric Approved Identity of Passport and Immigration Papers. [We are making a submission to the Journal of Banking and Financial Technology].

Advancing phosphorus foliar fertilization with nano-hydroxyapatite: mechanisms and agricultural relevance

<title>Abstract</title> Phosphorus (P) use in agriculture remains inefficient and poses long-term environmental concerns. We investigate the uptake, redistribution, and efficacy of foliar-applied nano-hydroxyapatite (nHAp) in P-deficient barley (Hordeum vulgare), aiming to clarif...

PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation

Abstract Programmed cell death protein 1 (PD-1) is expressed by T cells during progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease caused by the human-only JC polyomavirus. Why PD-1 blockade finds variable success in PML patients is unclear. Brain C...

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic...

Beyond the binary: a patient-centred approach to SSRIs and pregnancy

Purpose This study aims to examine the polarised discourse surrounding selective serotonin reuptake inhibitor (SSRI) use during pregnancy and to propose a human rights-based and autonomy-focused approach grounded in reproductive justice and shared decision-making. Design/methodol...

Defining ‘psychedelic’

Humphry Osmond coined the term ‘psychedelic’ in 1956, conjoining ‘psyche’ for ‘soul’ and ‘delic’ for ‘to manifest’ or ‘illuminate’. Soul-illumination is a compound noun that describes a psychological state or process. Osmond intended for it to be a taxonomic noun—naming, not just...

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

Game Developments [Simulation and Convergence Scenarios]

There are tools to fastly simulate the Universe in Diverse Scenarios : among those tools, are mainly the Game Development tools. We will introduce few notes about them.

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...

Triple potentiator combinations increase the functional correction of several CFTR gating mutants

The Trikafta drug combination, comprising the corrector tezacaftor (VX-661), the potentiator ivacaftor (VX-770) and the dual corrector/potentiator elexacaftor (VX-445), has been FDA-approved for treatment of cystic fibrosis caused by ~300 cystic fibrosis transmembrane conductance...

Resolving Hidden Stoichiometriesin Bacterial ProteasomeActivator (Bpa)-Substrate Complexes by Cryo-EM and Charge DetectionMass Spectrometry

Abstract Bacterial proteasome activator (Bpa) is a regulatory particle within the Mycobacterium tuberculosis (Mtb) proteasome system that facilitates ATP-independent substrate engagement and delivery to the 20S core particle (CP) for degradation. The best characterized Bpa substr...

Skills to build the nation: immigrant labour market and Canadian nationalism

In Skills to Build the Nation, Chatterjee argues that the postwar focus in Canadian immigration and integration policies on skill (and, relatedly, Canadian experience) is not instrumental but the l...