King's College London

Long-term outcomes of first episode affective psychosis in postpartum women

BACKGROUND: Outcomes of first episode postpartum psychosis and their distinction from outcomes of non-postpartum psychosis are poorly characterised. AIMS: To characterise the disease course and outcomes of first episode postpartum psychosis, compared with first episode non-postpa...

A process evaluation of a randomized clinical trial of selective decontamination of the digestive tract in ventilated adults admitted to intensive care: the SuDDICU PE study

The SuDDICU trial evaluated the effectiveness of selective digestive decontamination (SDD), a prophylactic antibiotic regimen comprising oral, gastric and intravenous (IV) components in ventilated adults admitted to intensive care. The trial recruited 9289 participants in 26 clus...

Accelerating charging dynamics of electric double-layer capacitors

Electric double-layer capacitors (EDLCs), consisting of an ionic fluid between two metallic electrodes, are electrochemical energy storage devices complementary to batteries, allowing for a faster charge/discharge. The charging dynamics in response to a voltage step features a va...

Amplification of computational power by the multiplication of bacteria exploring microfluidic networks encoding mathematical problems

Computational resources required for solving NP-complete problems grow exponentially with a polynomial increase in problem size. This exponentially increasing computational resource is runtime for sequential electronic computers and space for massively parallel DNA computing. Her...

Fundamental principles: purity and neutrality

Abstract I offer a new position in debates about the Purity Principle, roughly, whether the fundamental truths/facts may have nonfundamental constituents. Purity is intuitively compelling and plays an important role in many debates. Nevertheless, there are also reasons to doubt P...

Algorithmic imaginaries: Definition and critical questions

Algorithmic systems play an increasingly central role across a variety of social domains. Over the last few years, various concepts have been developed in the interdisciplinary field of algorithm studies to understand how people make sense of these systems and interact with them...

Incidence and relative risk of negative outcomes of psychological interventions for pediatric posttraumatic stress disorder: a systematic review and meta‐analysis of randomized controlled trials

Background Negative outcomes of psychological treatments for pediatric posttraumatic stress disorder (PTSD) have been underresearched. Although reporting has increased over the years, a comprehensive systematic review and meta‐analysis is lacking. Methods We conducted a preregist...

Sewerage and rural disadvantage in England 1945–74

Abstract Prior to local government reorganisation in 1974, English rural councils were largely responsible for local sewerage services. In 1945, British national sentiment supported reversing interwar neglect of rural areas through investment in new housing and affiliated service...

Functional Assessment of a Constitutively Activating CASR Variant Causing Autosomal Dominant Hypocalcaemia

Abstract Context A rare cause of hypocalcaemia, autosomal dominant hypocalcaemia type 1 (ADH1) arises from a gain-of-function variant of the calcium sensing receptor gene (CASR). Objective Three patients from two unrelated families, presenting with hypocalcaemia and other biochem...

The Co-Occurrence of Postural Orthostatic Tachycardia and Functional Neurological Disorder: A Meta-Analysis and Narrative Synthesis

Background: Functional Neurological Disorder (FND) and Postural Orthostatic Tachycardia Syndrome (POTS) are both complex, often debilitating conditions that frequently affect young women and involve high symptom burdens and psychiatric comorbidity. Although clinical overlap betwe...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Asymptotics of predictive distributions driven by sample means and variances

Abstract Let alpha Subscript n Baseline left parenthesis dot right parenthesis equals double struck upper P left parenthesis upper X Subscript n plus 1 Baseline element of dot vertical bar upper X 1 comma ellipsis comma upper X Subscript n Baseline right parenthesis <mml:math xml...

Learning Domains for Undergraduate Dental Behaviour Support: The BeSiDe Curriculum Learning Outcomes

OBJECTIVES: Dental Behaviour Support (DBS) refers to informal and formal strategies and interventions that support patients' acceptance and experience of oral healthcare. DBS plays a crucial role, particularly for vulnerable groups, yet training across dental curricula remains in...

Understanding funding-related bias in gambling research: insights from unhealthy commodities industries and medical/pharmaceutical research – a scoping review

Despite the risk of funding-related bias (RoFRB) introduced by industry funding in gambling research, empirical investigations remain limited. To inform understanding of RoFRB in gambling research, this scoping review synthesized 52 peer-reviewed studies (2019–2024) spanning gamb...

Moral emotion processing in euthymic bipolar disorder: insights from network analysis

Abstract Background Bipolar disorder (BD) is associated with facial emotion recognition (FER) deficits. Among these, impairments in recognizing moral emotions may be especially relevant to social dysfunction, but their relationship with brain structure remains poorly defined. Met...

Understanding Caregivers’ Experiences of Rett Syndrome: A Multinational Study of Symptoms and Meaningful Outcomes of Potential Treatments

Caregivers have first-hand experience of facing the daily challenges of Rett syndrome (RTT). The aim of this study was to understand caregivers’ experiences of RTT, including challenging symptoms that caregivers hope novel therapies will address. This non-interventional, qualitat...

Scalar position characteristics and translocation rates of different lateral wall electrodes within the cochlear basal turn: a cone beam computed tomography study

PURPOSE: This retrospective study systematically compared scalar position characteristics and translocation (STL) rates within the cochlear basal turn (CBT) across three different lateral wall (LW) electrodes. METHODS: The study included 148 morphologically normal cochleae implan...

A controlled trial of a co-designed virtual reality experience to support wellbeing in students

Abstract Increasing rates of mental health problems among university students require innovative interventions. This study evaluated a multi-sensory, virtual reality (VR) intervention aimed at reducing stress and exam anxiety among students at a healthcare university in the UK. P...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Clients’ views and experiences of individual placement and support: an employment program for people in treatment for substance use

Background Individual Placement and Support (IPS) was originally developed to help people with serious mental illnesses into competitive employment but has recently shown positive results when delivered to people in treatment for substance use. This paper explores clients’ views...