King's College London

Michael Derek Waterfield

Abstract Mike Waterfield was a biochemist with a passion for the application of state-of-the-art technology, and his developments in protein sequencing opened doors previously closed to the research community. Most profoundly, through the sequencing of platelet-derived growth fac...

Human cortical networks trade communication efficiency for computational reliability

Brains are often described as cost-efficient communication networks, optimally balancing the cost of long connections with the benefits of fast communication. Here, inspired by the "use it or lose it" principle, we present a novel game-theoretic model of self-organizing neural un...

Lernfähigkeit als Überlebensfähigkeit: Wie Deutschland in der Sicherheitspolitik besseres Lernen lernen kann

Zusammenfassung Der Artikel analysiert die Bedeutung des institutionellen Lernens und einer guten Fehlerkultur für die deutsche Außen- und Sicherheitspolitik. Zunächst fasst er den Forschungsstand zu den Möglichkeiten, Grenzen und Voraussetzungen erfolgreichen Lernens sowie einer...

Elevated translocator protein in skull bone marrow is linked to human chronic pain

The skull bone marrow (SBM) is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography/magnetic resonance imaging, here, we show that the levels of 18-kilodalton translocator protein (TSPO), a pu...

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

ABSTRACT Aim Drug‐target Mendelian randomisation (MR) studies investigate whether genetically proxied modulation of druggable proteins affects the risk of periodontitis, thereby identifying potential pharmacological targets. Methods A systematic review was conducted following PRI...

Characteristics of Monozygotic Twins Discordant for Anorexia Nervosa: Comprehensive Risk Evaluation for Anorexia Nervosa in Twins (CREAT) Study

ABSTRACT Objective To characterise the clinical and phenotypic profile of the Comprehensive Risk Evaluation for Anorexia nervosa in Twins (CREAT) cohort, identify candidate risk and illness‐related correlates of AN, and establish a foundation for forthcoming biological, neuroimag...

9.4‐Tesla magnetic resonance imaging in focal epilepsy patients with high‐resolution surface‐based profiling of focal cortical dysplasias

Abstract Objective The detection of subtle epileptogenic lesions such as focal cortical dysplasias (FCDs) is a clinical challenge in the management of drug‐resistant focal epilepsy (DRFE). Ultra‐high‐field (UHF) magnetic resonance imaging (MRI) offers increased signal‐to‐noise ra...

Food choices and beliefs in adults with inflammatory bowel disease in Sweden

Abstract Objectives Diet is a recognised risk factor for inflammatory bowel disease (IBD) and a management strategy. Concerns persist regarding the adverse effects of restrictive diets, including nutritional deficiencies and selective eating. The impact of IBD on patients’ belief...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

Dysphagia care processes on acute stroke wards: an ethnographic study of barriers and facilitators relevant to stroke‐associated pneumonia

Introduction Dysphagia is associated with increased risk of stroke-associated pneumonia (SAP). The multifactorial pathophysiology of SAP and the interplay of care processes make it challenging to unpack which components are associated with risk of SAP. The aim of the research was...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Kidney transplantation in older people (KTOP): a longitudinal, qualitative study of kidney transplant experiences in older, frail adults

Abstract Background Transplantation rates are increasing in those who are older and frail, driven by an aging dialysis population. This longitudinal, qualitative study explores how older adults navigate the journey from dialysis to transplantation and how frailty is experienced a...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Development and validation of the personal recovery scale (ReConnect) for mental health in Ethiopia

Background: Socio-cultural context is crucial for conceptualising personal recovery in mental health, but existing measures are from Western, high-income countries. Aim: To develop and validate a mental health personal recovery measure for people with mental health conditions in...

Autistic neural ‘shiftability’: the distinct pharmacological landscape of the autistic brain

Functionally inter-connected large-scale brain networks regulated by multiple neurotransmitter systems underpin complex human behaviour. A wide range of alterations in this neurofunctional landscape have been associated with autism. However, this evidence is mostly derived from c...

‘It’s a bit like a legend where you have to tell it again and again’: disclosure practices in single father families via surrogacy

Aims/Background Research has shown that children born through surrogacy to heterosexual and gay couples are often told about this at an early age. However, to our knowledge no studies have explored how single fathers approach telling and talking about their route to parenthood wi...

Leveraging Foundation Models for the Characterisation of Small RNA Properties

ABSTRACT Small interfering RNAs (siRNAs) provide a promising therapeutic approach capable of selectively silencing disease-associated genes; however, achieving high efficacy and specificity while minimising off-target effects remains a significant challenge. Endogenous small RNAs...

Anticipating health and care trajectories from routinely collected social care records

Abstract Predictive modelling in healthcare has advanced rapidly, yet social care systems, despite their central role in supporting vulnerable populations, remain underexplored in this domain. In this study, we apply machine learning to a large, pseudonymised dataset of social ca...

Overview of the re‐evaluation of trace elements as nutritional feed additives in the European Union : characterization, safety, and efficacy

The re-evaluation of feed additives in the European Union was outlined in the Regulation (EC) No 1831/2003. The primary objectives were to ensure safety and verify efficacy, as well as to update authorizations and phase out unsafe additives or those in which the industry expresse...