King's College London

Anticoagulation and Antiplatelet Therapy in Chronic Subdural Hematoma: A Multicenter Evaluation

BACKGROUND AND OBJECTIVES: Chronic subdural hematomas (cSDH) are among the most common neurosurgical pathologies. Older adults also often have comorbidities treated with anticoagulant and antiplatelet (ACAP) medications. Managing clinicians frequently must weigh the benefits and...

CB1 receptor-enriched functional connectivity analysis revealed target-specific modulation by cannabidiol in early psychosis

BACKGROUND: Cannabidiol (CBD) has emerged as a potential antipsychotic treatment, acting as a negative allosteric modulator of cannabinoid type-1 (CB1) receptors within the endocannabinoid system. Although previous neuroimaging studies have shown that CBD induces changes in aberr...

Fit to fly? Evaluating airline guidance for passengers with orthopaedic immobilisation

INTRODUCTION: Air travel with cast immobilisation increases the risk of compartment syndrome and venous thromboembolism due to cabin pressure-related tissue swelling and venous stasis. Despite these concerns, guidance on flying with casts is often vague and inconsistent. This stu...

Webinars about child and adolescent psychiatry can support professionals in war-affected regions: lessons from the ESCAP-Ukraine webinar initiative

War has a profound impact on child and adolescent mental health and service provision. This requires creative internationally supported response to strengthen professional capacity in trauma care, psychosocial support and evidence based clinical practice in child and adolescent p...

Quality‐of‐life and late effects after transabdominal cerclage: A nationwide matched cohort study

INTRODUCTION: A transabdominal cerclage is inserted to prevent recurrent midtrimester loss and spontaneous preterm birth. The transabdominal cerclage often remains as a permanent foreign body for years. Synthetic materials within the abdomen, cesarean birth, and prior adverse pre...

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D...

Nut consumption and the risk of hypertension: a systematic review and dose response meta-analysis of prospective studies

Abstract Previous studies have suggested that a high intake of nuts may reduce the risk of hypertension, however, the available data have been limited. Several additional studies have recently been published on the topic. We therefore conducted a systematic review and meta-analys...

From Sentencing Hearings to Sentencing Conferences

Abstract This article presents a theoretical case for partial deformalisation of sentencing hearings, whereby the offender and the victim would be invited to add their particularistic perspectives on crime and punishment in unmediated nonhierarchical settings. It is argued that p...

Evaluating the Group Responses After Disasters and Emergencies (GRADE) psychosocial training package pilot: A feasibility randomised controlled trial with trauma-exposed managers in the civil service

OBJECTIVE: This study assessed the feasibility of delivering and evaluating the Group Responses After Disasters and Emergencies (GRADE) training intervention among managers in trauma-exposed roles. METHOD: A pre-registered two-arm randomised controlled feasibility trial was condu...

Artificial intelligence-enabled non-invasive quantification of left ventricular end-systolic pressure: an in silico analysis

Abstract Background Invasive pressure–volume loop (PVL) analysis is the gold standard method to quantify myocardial physiology. To enhance broader clinical applicability, non-invasive approaches to derive left ventricular (LV) PVLs have gained prominence, typically estimating LV...

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

BACKGROUND: Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood-onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult-derived paradigms. OBJECTIVE: To identify key gaps in the...

Development of Periodontal Organoid-like Constructs Using Human Periodontal Ligament and Gingival Epithelial Cells: Comparison of Two Assembly Strategies

Periodontal organoid research remains underdeveloped, largely due to the lack of standardized fabrication protocols and multicellular constructs capable of reproducing epithelial–mesenchymal interactions relevant to periodontal biology. In particular, it remains unclear whether d...

Implementation of minimum unit pricing for alcohol in Scotland and subsequent rates of hospital-admitted self-harm: controlled interrupted time series analysis

BACKGROUND: Harmful alcohol use is a major modifiable risk factor for self-harm. We aimed to examine associations between minimum unit pricing for alcohol, introduced in Scotland in 2018, and rates of hospital-admitted self-harm. METHODS: Data were obtained from Public Health Sco...

Comparison of parametric versus machine-learning multiple imputation in clinical trials with missing continuous outcomes

Abstract Background Flexible machine-learning (ML) models to generate imputations within the Multiple Imputation (MI) framework has recently gained traction, particularly in non-randomised observational settings. For randomised controlled trials (RCTs), it is unclear whether ML a...

Balancing cancer innovation with sustainable care

<i>Investment in innovative drugs must not come at the expense of wider cancer services</i>