King's College London

Anticipating health and care trajectories from routinely collected social care records

Abstract Predictive modelling in healthcare has advanced rapidly, yet social care systems, despite their central role in supporting vulnerable populations, remain underexplored in this domain. In this study, we apply machine learning to a large, pseudonymised dataset of social ca...

PPI and researcher perspectives of islet transplantation therapy for type 1 diabetes

AIMS: Islet transplantation offers the potential of a cure for type 1 diabetes (T1D), but the limited availability of human donor islets means that this therapy is currently only available to a small group of people with T1D who have intractable hypoglycaemia. The shortage of don...

Interventions to reduce diabetes-related distress among adults with type 1 and type 2 diabetes: protocol for a systematic review and meta-analysis

Diabetes distress (DD) refers to the emotional and psychological burden experienced by individuals living with diabetes. Randomized controlled trials (RCTs) have investigated the efficacy of interventions on DD among adults with type 1 diabetes or type 2 diabetes. We aimed to sys...

Translation, Cultural Adaptation, and Evaluation of the Psychometric Properties of the Greek Version of the Rapid Weight Loss Questionnaire for Combat Sports Athletes

Rapid weight loss (RWL) is commonly practiced among combat sports athletes to reduce body mass before competition. The Rapid Weight Loss Questionnaire (RWLQ) is a self-report instrument designed to assess weight loss behaviors and practices. This study aimed to translate and cult...

Estimating the environmental impact of an HPC job – tools and challenges

Researchers and research funders are increasingly interested in understanding the environmental impacts of computational research, including impacts through both energy-intensive computations and the production and disposal of specialised computing hardware. However, these impact...

Enantiomer-dependent biodistribution and exposure determine the in vivo behavior of a pleurocidin-derived antimicrobial peptide

ABSTRACT Antimicrobial peptides (AMPs) display rapid bactericidal activity in vitro , but have largely failed as systemically administered therapeutics, indicating that intrinsic potency alone does not predict in vivo efficacy. Here, we examine how pharmacokinetics, stereochemist...

Clinical integration of trabecular bone score in precision osteoporosis care: a position statement by the Egyptian academy of bone and muscle health

Abstract Background Dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) has long been the gold standard for osteoporosis diagnosis, yet its inability to account for bone quality leads to a significant “sensitivity gap” in fracture risk prediction. This posit...

Disentangling the drivers of heterogeneity in SARS-CoV-2 transmission from data on viral load and daily contact rates

Abstract SARS-CoV-2 transmission is highly overdispersed, with a minority of individuals responsible for the majority of transmission, though the drivers of this heterogeneity are unclear. Here, we assess the contribution of variation in viral load and daily contact rates to this...

Estimating the Prevalence of Replication Research Is Challenging, Not Least Because Even a Thorough Database Search Can Be Shallow

Replication—duplicating methods to reexamine findings—is the bedrock of science. To survey this foundation for psychological science, Makel et al. (2012) searched 100 psychology journals, finding that all-fields database searches for replicat* returned 2% to 3% of articles. Codin...

When habit prevails: a causal test of policy feedback theory using a pension reform

Abstract Elderly voters are a growing, politically powerful electoral bloc, and their pensions often constitute the largest component of welfare state. We know that cuts can provoke electoral backlash, but it is less clear whether benefit expansions mobilize retirees. Some policy...

The outcomes of surrogate pregnancy using donor egg compared to surrogate’s egg: a systematic review

Abstract Purpose Surrogacy is either gestational (GS) using donor egg or traditional (TS) using surrogate’s own egg. GS is increasing, partly from assumptions over less difficulty in transferring the baby to intended parents. This systematic review investigates obstetric outcomes...

The Psychoses : Jacques Lacan’s Seminar III (1955–1956)

SUMMARY During the academic year 1955–1956, Jacques Lacan, a prominent psychiatrist and psychoanalyst, delivered his third seminar in Paris. Seventy years later it remains little known among psychiatrists in the UK. Seminar III was devoted to the psychoses, particularly the delus...

Debating the Delphi View of Dyslexia: A Response to Metsala, Morsanyi and Colleagues

ABSTRACT Several commentators have discussed the consensus view of dyslexia that emerged from a Delphi survey reported by Carroll, Holden and colleagues. Here the authors respond to the commentaries, agreeing that different definitions of dyslexia may be required for different pu...

Prevalence of Mental Disorders in Parents With Intellectual Disabilities: A Systematic Review

ABSTRACT Background Research indicates that an increasing number of adults with intellectual disabilities (IDs) are becoming parents. Parents with ID face multiple challenges that increase their mental health risks. In order to ensure better detection and tailored care for parent...

Large-Scale Open Science Simulated Data to Study the Development of Brain and Behavior Relationships: Epidemiologic, Clinical, and Neuroimaging Characteristics

Both brain and behavior undergo considerable changes during adolescence, a time synonymous with the emergence several psychiatric disorders, including mood and psychotic disorders. Multiple studies have explored the interaction between brain and behavior during childhood and adol...

Maximal Minimal Spacing for Random Points

Abstract From $$N+1$$ N + 1 random points on a line we wish to select $$M+1$$ M + 1 points so as to maximize the minimal spacing between them. We consider an initial configuration with independent and identically distributed spacings. Equivalently, the points are arrival times of...

Implementation of health independent Domestic Violence Advisors (hIDVA): a qualitative study in five NHS Trusts

Abstract Background People who experience domestic abuse report increased use of healthcare services, compared to those not experiencing abuse. Independent Domestic Violence Advisors (IDVA) are evidence-based programmes that provide emotional and practical support to people exper...

A liquid handling platform for standardised quantification of cell-free enzymatic activity encoded by antimicrobial resistance genes

ABSTRACT Antimicrobial resistance (AMR) is a growing global threat to human health, and rapid methods for characterising emerging antimicrobial resistance genes (ARGs) are needed. Here, we develop a semi-automated workflow using cell-free gene expression (CFE) systems to measure...

Implementing day-case parathyroidectomy in a large multi-site UK trust: a prospective case series

INTRODUCTION: Advancements in minimally invasive techniques, coupled with structured perioperative protocols, have rendered same-day discharge following parathyroidectomy increasingly viable. National recommendations, including those from the Getting It Right First Time (GIRFT) n...

Access in all areas? A round-up of developments in market access and health technology assessment: part 16

In this update we review new evidence on the rising prevalence of prior authorization rejections, delays and denials affecting US patients seeking access to branded prescription medications. We also examine a comparative study of cost-effectiveness thresholds cited in the USA and...