King's College London

Fundamental principles: purity and neutrality

Abstract I offer a new position in debates about the Purity Principle, roughly, whether the fundamental truths/facts may have nonfundamental constituents. Purity is intuitively compelling and plays an important role in many debates. Nevertheless, there are also reasons to doubt P...

Asymptotics of predictive distributions driven by sample means and variances

Abstract Let alpha Subscript n Baseline left parenthesis dot right parenthesis equals double struck upper P left parenthesis upper X Subscript n plus 1 Baseline element of dot vertical bar upper X 1 comma ellipsis comma upper X Subscript n Baseline right parenthesis <mml:math xml...

The Co-Occurrence of Postural Orthostatic Tachycardia and Functional Neurological Disorder: A Meta-Analysis and Narrative Synthesis

Background: Functional Neurological Disorder (FND) and Postural Orthostatic Tachycardia Syndrome (POTS) are both complex, often debilitating conditions that frequently affect young women and involve high symptom burdens and psychiatric comorbidity. Although clinical overlap betwe...

Incidence and relative risk of negative outcomes of psychological interventions for pediatric posttraumatic stress disorder: a systematic review and meta‐analysis of randomized controlled trials

Background Negative outcomes of psychological treatments for pediatric posttraumatic stress disorder (PTSD) have been underresearched. Although reporting has increased over the years, a comprehensive systematic review and meta‐analysis is lacking. Methods We conducted a preregist...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Functional Assessment of a Constitutively Activating CASR Variant Causing Autosomal Dominant Hypocalcaemia

Abstract Context A rare cause of hypocalcaemia, autosomal dominant hypocalcaemia type 1 (ADH1) arises from a gain-of-function variant of the calcium sensing receptor gene (CASR). Objective Three patients from two unrelated families, presenting with hypocalcaemia and other biochem...

Sewerage and rural disadvantage in England 1945–74

Abstract Prior to local government reorganisation in 1974, English rural councils were largely responsible for local sewerage services. In 1945, British national sentiment supported reversing interwar neglect of rural areas through investment in new housing and affiliated service...

Learning Domains for Undergraduate Dental Behaviour Support: The BeSiDe Curriculum Learning Outcomes

OBJECTIVES: Dental Behaviour Support (DBS) refers to informal and formal strategies and interventions that support patients' acceptance and experience of oral healthcare. DBS plays a crucial role, particularly for vulnerable groups, yet training across dental curricula remains in...

Understanding funding-related bias in gambling research: insights from unhealthy commodities industries and medical/pharmaceutical research – a scoping review

Despite the risk of funding-related bias (RoFRB) introduced by industry funding in gambling research, empirical investigations remain limited. To inform understanding of RoFRB in gambling research, this scoping review synthesized 52 peer-reviewed studies (2019–2024) spanning gamb...

Understanding Caregivers’ Experiences of Rett Syndrome: A Multinational Study of Symptoms and Meaningful Outcomes of Potential Treatments

Caregivers have first-hand experience of facing the daily challenges of Rett syndrome (RTT). The aim of this study was to understand caregivers’ experiences of RTT, including challenging symptoms that caregivers hope novel therapies will address. This non-interventional, qualitat...

Moral emotion processing in euthymic bipolar disorder: insights from network analysis

Abstract Background Bipolar disorder (BD) is associated with facial emotion recognition (FER) deficits. Among these, impairments in recognizing moral emotions may be especially relevant to social dysfunction, but their relationship with brain structure remains poorly defined. Met...

A controlled trial of a co-designed virtual reality experience to support wellbeing in students

Abstract Increasing rates of mental health problems among university students require innovative interventions. This study evaluated a multi-sensory, virtual reality (VR) intervention aimed at reducing stress and exam anxiety among students at a healthcare university in the UK. P...

Scalar position characteristics and translocation rates of different lateral wall electrodes within the cochlear basal turn: a cone beam computed tomography study

PURPOSE: This retrospective study systematically compared scalar position characteristics and translocation (STL) rates within the cochlear basal turn (CBT) across three different lateral wall (LW) electrodes. METHODS: The study included 148 morphologically normal cochleae implan...

Clients’ views and experiences of individual placement and support: an employment program for people in treatment for substance use

Background Individual Placement and Support (IPS) was originally developed to help people with serious mental illnesses into competitive employment but has recently shown positive results when delivered to people in treatment for substance use. This paper explores clients’ views...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

CB1 receptor-enriched functional connectivity analysis revealed target-specific modulation by cannabidiol in early psychosis

BACKGROUND: Cannabidiol (CBD) has emerged as a potential antipsychotic treatment, acting as a negative allosteric modulator of cannabinoid type-1 (CB1) receptors within the endocannabinoid system. Although previous neuroimaging studies have shown that CBD induces changes in aberr...

Anticoagulation and Antiplatelet Therapy in Chronic Subdural Hematoma: A Multicenter Evaluation

BACKGROUND AND OBJECTIVES: Chronic subdural hematomas (cSDH) are among the most common neurosurgical pathologies. Older adults also often have comorbidities treated with anticoagulant and antiplatelet (ACAP) medications. Managing clinicians frequently must weigh the benefits and...

Fit to fly? Evaluating airline guidance for passengers with orthopaedic immobilisation

INTRODUCTION: Air travel with cast immobilisation increases the risk of compartment syndrome and venous thromboembolism due to cabin pressure-related tissue swelling and venous stasis. Despite these concerns, guidance on flying with casts is often vague and inconsistent. This stu...

Artificial intelligence-enabled non-invasive quantification of left ventricular end-systolic pressure: an in silico analysis

Abstract Background Invasive pressure–volume loop (PVL) analysis is the gold standard method to quantify myocardial physiology. To enhance broader clinical applicability, non-invasive approaches to derive left ventricular (LV) PVLs have gained prominence, typically estimating LV...

From Sentencing Hearings to Sentencing Conferences

Abstract This article presents a theoretical case for partial deformalisation of sentencing hearings, whereby the offender and the victim would be invited to add their particularistic perspectives on crime and punishment in unmediated nonhierarchical settings. It is argued that p...