King's College London

Heterochronicity shapes brain network formation

Brain network formation unfolds on a nonuniform developmental timetable, with different cortical regions generating connections at different developmental phases. Generative network models (GNMs) aim to uncover the principles underpinning the organization of connectomes by creati...

Clinical and genetic risk factors for apolipoprotein L1-mediated chronic kidney disease in people of African ancestry with HIV

PURPOSE OF REVIEW: To summarize current understanding of the epidemiology, pathogenesis and management of HIV-Associated Nephropathy (HIVAN) and other forms of Apolipoprotein L1 (APOL1)-mediated chronic kidney disease (CKD) in people of African ancestry with HIV. RECENT FINDINGS:...

A longitudinal Bayesian framework for estimating causal dose-response relationships

Existing causal methods for time-varying exposure and time-varying confounding focus on estimating the average causal effect of a time-varying binary treatment on an end-of-study outcome, offering limited tools for characterizing marginal causal dose-response relationships under...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

We are all genocide scholars now: Palestine, Gaza, and the failures of security studies

For three years, the State of Israel has been committing genocide in Gaza, the latest and most intensive phase of a ‘slow-motion genocide’ inflicted on the Palestinian people over the past 80 years...

Exploring Positive Identity in Autistic Adolescents: A Feasibility and Acceptability Study of a Co-designed Group Intervention

BackgroundCultivating a positive identity may buffer against the adverse mental health outcomes often experienced by autistic individuals. Group settings can provide valuable spaces for identity consolidation. This study evaluated the feasibility and acceptability of a co-designe...

Peripheral CD4 + T‐Cell Reserve as a Potential Biomarker of CD20 × CD3 Bispecific Antibody Outcomes and BTK Inhibitor–Associated Immune Modulation in B‐Cell Lymphoma

ABSTRACT Bispecific antibodies (BsAbs) targeting CD20 × CD3 have achieved remarkable efficacy in relapsed or refractory (R/R) B‐cell lymphoma, yet clinical responses remain heterogeneous and predictive biomarkers are lacking. We retrospectively evaluated associations between peri...

Framing lying flat in China: Official media reports and online reader responses

Drawing on 65 Chinese official media reports and 895 reader comments, this study examines how lying flat was framed and negotiated between May 2021 and June 2022. Combining corpus-assisted frame analysis with Hall's encoding/decoding model, it analyses official media representati...

How Strategic Leaders Drive Firms in Ecosystems: Envisioning Value, Orchestrating Knowledge, and Shifting Roles

Abstract Research on business ecosystems has illuminated how ecosystems emerge, evolve, and transform, revealing ecosystem‐level dynamics and the central actors that orchestrate them. Yet, it is individual firms that continuously attempt to establish and shift the roles they play...

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Considering Autism in Binge-Type Eating Disorders: Broadening Beyond an Anorexia Nervosa-Focused Model

PURPOSE OF REVIEW: Research on Autism in eating disorders (EDs) has historically focused on anorexia nervosa (AN), with comparatively limited attention given to binge-type EDs such as bulimia nervosa (BN) and binge eating disorder (BED). This review summarises emerging evidence o...

Radiative Corrections and Reheating in Supergravity Models of Inflation

We consider the effects of radiative corrections in Starobinsky-like models of inflation, concentrating on models of inflation formulated in N=1 no-scale supergravity. Inflaton couplings with matter fields are necessary for reheating and these have an impact on loop corrections d...

Development and Validation of a Tool to Measure Documented Health Care Encounter Time

Importance Time toxicity, defined as the time patients spend receiving cancer treatment and interacting with health care systems, is an emerging treatment-related burden. Existing studies typically quantify time toxicity using health care contact days, which may inadequately capt...

Sex-dependent DNA methylation in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) shows well-established sex differences in incidence, age at onset and progression, but their biological basis is unclear. We hypothesised that the DNA methylation changes associated with ALS differ between the sexes, which would point to sex-sp...

Surgical Artificial Intelligence Innovation Trends and Regulatory Insights

Objective: To characterise the landscape of surgical artificial intelligence (AI) devices approved by the US Food and Drug Administration (FDA). Background: AI has the potential to improve surgical pathways, offering capability across screening, diagnosis, decision support, and i...

MOCA: A Hierarchical Semantic-Enhanced Code Edit Framework for Multilingual Code Co-Evolution

Multilingual code co-evolution aims to propagate code edits across programming languages while preserving functional consistency, yet the task remains challenging in real-world repositories. Our motivating examples reveal two key challenges: (1) Existing models fail to infer the...

As ‘Dead as Queen Anne’? Recruitment, Compulsion and the Crisis of British National Identity, April–May 1918

In spring 1918, a surge in volunteering occurred in Britain in response to the German Spring Offensive. Those who ‘volunteered’ were portrayed by the press as embodying the language of enthusiasm and the idea of national defence. Yet, when examined more closely, this characterisa...

Young adults’ experiences of using FREED-Mobile, a smartphone friendly intervention designed to facilitate help-seeking for eating disorders

Abstract Background Early intervention increases the likelihood of eating disorder recovery, yet many young people delay seeking professional support for eating difficulties. We developed a smartphone-friendly, online intervention - FREED-Mobile [FREED-M] to encourage early help-...

Evaluating Unsteady Forces in Turbulence-Modeled Flows from Vorticity and Reynolds Stress

Vortex force maps (VFMs) link vortical flow structures to aerodynamic forces through compact-domain integrals weighted by geometry-only Laplace potentials. Existing VFM demonstrations include inviscid, laminar, two-dimensional, and three-dimensional applications but cannot analyz...

Do participant testimony videos make people more interested in taking part in a clinical trial? A randomised Study Within a Trial (SWAT), registration SWAT203

Abstract Background Potentially eligible participants do not always agree to take part in trials when approached, which makes recruitment more challenging, time-consuming, and costly. We conducted a Study Within a Trial (SWAT) to evaluate whether showing people brief video testim...