King's College London

User experience and reported challenges with stoma care products: an online survey of people with a stoma

Abstract Background Quality of life (QoL) in people living with a stoma has been assessed by several patient-reported experience measures, but few studies have examined the quality of user experience (UX) associated with stoma care and management products specifically. This explo...

Factors Affecting the Acceptability of Mindfulness-Based Interventions Among Older Adults: A Systematic Literature Review

Abstract Background Mindfulness-based interventions (MBIs) are increasingly implemented to promote psychological wellbeing in later life. Although emerging evidence suggests that MBIs may improve wellbeing among older adults, fewer studies have examined the factors influencing th...

Capital taxation, income shifting and retained earnings: evidence from dividend tax reforms

Abstract In this paper, we analyse the effects of dividend tax reforms on tax revenues, income shifting and earnings retention. We examine two significant policy changes in Israel during the 2010s. Using administrative tax records, we study a permanent increase of 5 percentage po...

Similarity analysis of blood count reference intervals reveals no ethnic or geographic structure and supports personalised values

Abstract Blood reference intervals (RIs) underpin diagnostic interpretation and therapeutic monitoring worldwide. However, many widely used RI systems originate from limited historical cohorts and have been propagated across health systems without harmonised derivation protocols,...

Recent progress on the Minimal Model Program for foliations

We recall the work of Brunella, McQuillan and Mendes on the classification of foliations on projective surfaces. We then survey some recent work extending this classification to foliations on higher dimensional projective varieties.

The diminishing polyads of parenting: exploring cultural perspectives of ‘good parenting' using grounded theory analysis

Introduction This study investigates Italian parents' perceptions of ‘good parenting' and cultural variations. 250 mothers and 87 fathers were surveyed during the third trimester, with follow-ups at 6–12 weeks and 6 months postpartum. Methods Using Grounded Theory Analysis, data...

Visual, vestibular, and ocular motor changes during nitroglycerin‐triggered vestibular migraine

BACKGROUND: Intravenous nitroglycerin (NTG) is a well-established model for provoking migraine attacks, but it has not previously been used to characterize vestibular migraine (VM). Different types of nystagmus have been reported during spontaneous VM attacks. We aimed to measure...

“I didn’t even know humans could get polio … I swear that’s for dogs.” A co-produced, thematic analysis exploring adolescent attitudes to vaccines

Abstract Background Immunisation forms a cornerstone of public health policy. However, uptake rates of routine vaccines offered in adolescence are sub-optimal. In 2023/24, for example, HPV uptake in England, for example, was 72.9% of girls and 67.7% of boys in school year 8 (aged...

Hypertrophic cardiomyopathy: a genome-wide association meta-analysis and polygenic risk score

ABSTRACT Background Hypertrophic cardiomyopathy (HCM) is a heritable trait with marked variability in expression and outcomes. Our aims were to discover new genetic loci associated with HCM and to test the effect of a new polygenic risk score (PRS) on incidence, phenotype and out...

Direct estimation of wildfire emissions at high latitudes from combined polar orbiter FRP and Sentinel-5P CO data

Abstract. High Latitude (HL) landscape fires are an important source of greenhouse gases and aerosols, with growing significance under rapid anthropogenic climate change-induced warming. Current fire emission inventories are mostly ‘bottom-up’ in nature; combining, or relying on...

Prevalence and Clinical Correlates of Autistic Traits Across Eating Disorder Diagnoses: A Retrospective Analysis of Clinical Service Data

Background: Autistic traits are overrepresented among individuals with anorexia nervosa (AN) and are associated with greater eating disorder (ED) psychopathology, psychological distress, and work and social functioning difficulties in this population. However, less is known about...

Comparing outcomes using low‐dose apixaban and anti‐Xa monitoring and vitamin K antagonists in patients with renal replacement therapy

Background Guidelines recommend oral anticoagulation for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism. Outside the United States, apixaban is unlicensed for use in patients with end‐stage renal disease (ESRD) receiving renal replacem...

Opportunities and challenges of generative AI in the research lifecycle

Artificial intelligence (AI) is increasingly being explored and adopted across the research lifecycle, from idea generation and literature discovery to data analysis, manuscript preparation, and editorial and peer-review processes. This perspective provides an overview of AI’s ro...

Longitudinal dynamics of gene expression and metabolomics in an aging population cohort

Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudinal whole-blood gene expression and metabolite levels in 335 females over 8 year...

Improving diabetes management in older adults with cancer: a quality improvement project to enhance monitoring during steroid-based systemic anti-cancer therapy

PURPOSE: Older adults undergoing systemic anti-cancer therapy (SACT) with steroids are at high risk of developing steroid-induced hyperglycaemia (SIH). However, monitoring and management remain inconsistent. This quality improvement project (QIP) involved developing and evaluatin...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

PrEgabalin for Treatment Resistant generalised Anxiety disorder (PETRA): study protocol for a double-blind randomised controlled trial set in the UK

Generalised anxiety disorder (GAD) is common and increasingly recognised in primary care. Although antidepressants and psychological therapies are first-line treatments, many patients have residual anxiety and limited access to therapy. Evidence for effective next-step pharmacolo...

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

ABSTRACT Aim Drug‐target Mendelian randomisation (MR) studies investigate whether genetically proxied modulation of druggable proteins affects the risk of periodontitis, thereby identifying potential pharmacological targets. Methods A systematic review was conducted following PRI...

Michael Derek Waterfield

Abstract Mike Waterfield was a biochemist with a passion for the application of state-of-the-art technology, and his developments in protein sequencing opened doors previously closed to the research community. Most profoundly, through the sequencing of platelet-derived growth fac...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...