King's College London

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D...

Evaluating the Group Responses After Disasters and Emergencies (GRADE) psychosocial training package pilot: A feasibility randomised controlled trial with trauma-exposed managers in the civil service

OBJECTIVE: This study assessed the feasibility of delivering and evaluating the Group Responses After Disasters and Emergencies (GRADE) training intervention among managers in trauma-exposed roles. METHOD: A pre-registered two-arm randomised controlled feasibility trial was condu...

Webinars about child and adolescent psychiatry can support professionals in war-affected regions: lessons from the ESCAP-Ukraine webinar initiative

War has a profound impact on child and adolescent mental health and service provision. This requires creative internationally supported response to strengthen professional capacity in trauma care, psychosocial support and evidence based clinical practice in child and adolescent p...

Quality‐of‐life and late effects after transabdominal cerclage: A nationwide matched cohort study

INTRODUCTION: A transabdominal cerclage is inserted to prevent recurrent midtrimester loss and spontaneous preterm birth. The transabdominal cerclage often remains as a permanent foreign body for years. Synthetic materials within the abdomen, cesarean birth, and prior adverse pre...

Nut consumption and the risk of hypertension: a systematic review and dose response meta-analysis of prospective studies

Abstract Previous studies have suggested that a high intake of nuts may reduce the risk of hypertension, however, the available data have been limited. Several additional studies have recently been published on the topic. We therefore conducted a systematic review and meta-analys...

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

BACKGROUND: Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood-onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult-derived paradigms. OBJECTIVE: To identify key gaps in the...

Comparison of parametric versus machine-learning multiple imputation in clinical trials with missing continuous outcomes

Abstract Background Flexible machine-learning (ML) models to generate imputations within the Multiple Imputation (MI) framework has recently gained traction, particularly in non-randomised observational settings. For randomised controlled trials (RCTs), it is unclear whether ML a...

Development of Periodontal Organoid-like Constructs Using Human Periodontal Ligament and Gingival Epithelial Cells: Comparison of Two Assembly Strategies

Periodontal organoid research remains underdeveloped, largely due to the lack of standardized fabrication protocols and multicellular constructs capable of reproducing epithelial–mesenchymal interactions relevant to periodontal biology. In particular, it remains unclear whether d...

Implementation of minimum unit pricing for alcohol in Scotland and subsequent rates of hospital-admitted self-harm: controlled interrupted time series analysis

BACKGROUND: Harmful alcohol use is a major modifiable risk factor for self-harm. We aimed to examine associations between minimum unit pricing for alcohol, introduced in Scotland in 2018, and rates of hospital-admitted self-harm. METHODS: Data were obtained from Public Health Sco...

Balancing cancer innovation with sustainable care

<i>Investment in innovative drugs must not come at the expense of wider cancer services</i>