King's College London

Alzheimer's Co‐Pathology Burden on Basal Forebrain Atrophy and Cognitive Impairment in Dementia with Lewy Bodies: A Cross‐Sectional Pilot Study

Objective Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer's disease (AD), with significant pathological overlap between the two conditions. However, the impact of Alzheimer's co‐pathology on basal forebrain (BF) atrophy and its...

A Prospective Study on the Effect of Coronal Tooth Structure Loss on the Survival of Root Canal‐Retreated Posterior Teeth Restored With Metal Ceramic Crowns With up to 10‐Year Follow‐Up

ABSTRACT Aim The primary aim of this study was to evaluate whether the volume of residual coronal tooth structure influences the survival of root canal‐retreated posterior teeth with up to 10‐year follow‐up. Secondary aims were to assess whether 12‐month radiographic findings and...

Validity and reliability of the pica, ARFID and rumination disorder interview- ARFID questionnaire (PARDI-AR-Q) in Turkish adults

Avoidant/Restrictive Food Intake Disorder (ARFID) is increasingly recognized as a clinically significant eating disorder across the lifespan, yet psychometrically validated assessment tools in non-English-speaking adult populations remain scarce. The Pica, ARFID and Rumination Di...

How Does the Time from Intraoperative Culture Harvest to Incubation Impact Culture Positivity in Orthopaedic Surgeries? A Case–Control Study

Background: Orthopaedic infections require accurate microbiological diagnosis for effective treatment. This study aimed to evaluate the impact of an accelerated protocol for culture harvesting and incubation on culture positivity rates in orthopaedic surgeries, comparing it to th...

Interdental brushing behaviour in adults: Influence of periodontal status and socioeconomic factors

Abstract Aim To evaluate patterns of interdental brush (IB) use across different stages and grades of periodontitis and to examine associations with socioeconomic, demographic, and behavioural factors. Methods This cross-sectional study included 375 adults referred for secondary...

Algal bioactive compounds for next-generation biopesticides: a multi-target resource for sustainable pest management

Abstract The rapid growth in global population and the incessant demand for food warrant greater attention to sustainable agricultural practices. To ensure adequate food security, protection of crops from exposure to biotic agents (e.g., pathogens and insects) is imperative. Over...

Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis

Abstract Clonal haematopoiesis (CH) is driven by somatic mutations in haematopoietic stem cells that generate clonal populations detectable in peripheral blood and is present in 10–20% of individuals over the age of 65. Mutations in DNMT3A and TET2 are the most common drivers and...

Can discussions with patients and the public clarify missing data mechanisms for digital outcome measures?

Abstract Background Analysis of clinical trials with missing data requires statistical assumptions. When novel digital outcome measures are used, it is particularly important to understand trial participants’ experiences with the device. This can illuminate the reasons for and sp...

Examining the Interchangeability of Two Different Patient‐Reported Global Assessment Measures in an Observational Axial Spondyloarthritis Cohort

OBJECTIVE: The goal of this study was to determine if patient global assessment (PGA) scores reported by patients with axial spondyloarthritis (AxSpA) prior to the development of the ASDAS can be used as a substitute for the global item of the ASDAS formula. METHODS: Data from th...

The Micro-Expression Decoder: A Preliminary Mixed-Methods Evaluation of Training in Subtle Facial and Non-Verbal Cue Recognition in Final-Year Medical Students

Background/Objectives: Subtle facial and interactional cues may prompt clinicians to explore possible anxiety, confusion or hesitation, but they do not establish a patient’s internal state. The Micro-Expression Decoder (MED) links cue recognition with tentative interpretation, di...

N-Acetylcysteine Attenuates Amikacin-Induced Biochemical, Inflammatory, and Histopathological Alterations in Mice

Background: Amikacin is an effective aminoglycoside antibiotic, but its clinical use is limited by nephrotoxicity, hepatotoxicity, and neurotoxicity. N-acetylcysteine (NAC), a glutathione precursor and antioxidant, may help reduce these side effects. This study evaluated whether...

GenAI-based group awareness tools for supporting collaborative learning

In Computer-Supported Collaborative Learning (CSCL), Group Awareness Tools (GATs) collect raw data produced during collaboration, interpret awareness information from that data, and visualize awareness information to support students in perceiving differences among themselves in...

Comparison of Actigraphy and Polysomnography in a Sleep Centre Cohort

ABSTRACT Polysomnography (PSG) is the gold standard for sleep assessment, but actigraphy offers a low‐cost, non‐invasive multi‐night alternative. MotionWatch 8 was compared to PSG in a tertiary sleep centre cohort ( n = 107; age 37.6 ± 14.9 years; 56% female), examining whether a...

Cross-cultural adaptation and validation of the Persian version of the International Hip Outcome Tool-12 (iHOT-12-Pr) in young to middle-aged active adults with hip disorders

To our knowledge, no validated Persian version of the 12-item International Hip Outcome Tool (iHOT-12) has been published for assessing active adults with hip disorders. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the Persian iHOT-...

The Rare dISease Evaluation (RISE) study: a survey-based investigation of medical student experience and knowledge of rare disease in the UK

Abstract Background Rare diseases are a significant public health concern, with over 6,000 diseases identified with an estimated collective point prevalence of 5.6–6.9%. People living with rare disease face numerous challenges within healthcare including prolonged time to diagnos...

Physical activity in advanced urological cancers undergoing immune checkpoint inhibitor treatment: a qualitative study exploring patient perspectives and experiences

Physical activity (PA) can improve health and treatment outcomes in cancer patients. However, patients with advanced cancer undergoing immune checkpoint inhibitor (ICI) therapy often experience debilitating side-effects that impact PA participation. Because PA experiences in pati...

Assessing glymphatic role in the association between choroid plexus enlargement and white matter lesions load: The uncertain path through diffusion tensor imaging along the perivascular space (DTI-ALPS)

Background The choroid plexus (CP) is involved in cerebrospinal fluid production, immune surveillance, and brain fluid homeostasis. CP enlargement has been linked to neuroinflammation, glymphatic dysfunction, and white matter lesion (WML) burden, but the mechanisms underlying the...

AI-augmented colorectal cancer MDT concordance modelling: a prospective evaluation of performance, interpretability, and provider-side budget impact

Abstract Purpose Colorectal multidisciplinary teams (MDTs) face increasing workload. We evaluated whether routinely collected colorectal MDT variables could support local MDT concordance modelling, interpretable feature attribution, and provider-side budget impact estimation. Met...

α-Latrotoxin and Pain: A Nociceptor Perspective on Latrodectism

Alpha-latrotoxin (α-LTX) is the principal vertebrate-specific neurotoxin in widow spider (Latrodectus) venom and a powerful presynaptic secretagogue. Although its receptors, pore-forming activity and stimulation of neurotransmitter release have been studied extensively in central...

‘I’m fighting my case all the time’. Candidacy, stigma, and negotiated access in cancer care: experiences of adults with intellectual disability and their supporters

Abstract Background People with intellectual disability experience substantial inequities in cancer outcomes, including later-stage diagnosis and higher mortality. While disparities in awareness and screening are well documented, less is known about how inequities arise across th...