Fudan University

Temperature-dependent inhibition of methane oxidation by ammonium in paddy soils

Rice paddy soils are major sources of atmospheric methane emissions, contributing significantly to global warming. Methane oxidation by microbes regulates methane release from soils, but the process is influenced by temperature and nitrogen status. However, the interactive effect...

Co-occurrence patterns and related risk factors of type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease

Type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) are interrelated metabolic disorders worldwide. We aimed to characterize global co-occurrence patterns of T2DM and MASLD from a spatial perspective and to identify shared risk fac...

No Universal Remainder Rate for Chambolle-Dossal Acceleration

Chambolle-Dossal acceleration guarantees F(x_n) - F* = o(n^(-2)) for every fixed smooth convex loss with a minimizer. We show that this qualitative improvement admits no universal quantitative rate. For every damping parameter alpha > 3 and positive nondecreasing gain G(n) tendin...

Stabilizing Macrophage Immune States through Fusion-Enabled Nanoparticle-Based Intracellular Drug Depots for Durable Ulcerative Colitis Therapy

Abstract Ulcerative colitis (UC) is characterized by persistent colonic inflammation accompanied by the accumulation of pro-inflammatory M1-like macrophages, which sustain cytokine production and impair mucosal repair. Promoting a shift toward a pro-resolving M2-like phenotype is...

Extraordinary Cation-Replace-Cation Antisite Defects Predominate in α-Phase Bi2SeO5

Abstract As a newly identified single-crystalline van der Waals dielectric with a high dielectric constant, α-phase Bi2SeO5 (α-BSO) plays a pivotal role in advancing 2D electronic devices. In this work, we systematically investigate the defect properties of α-BSO using first-prin...

Myf5 Progenitors Define the Lineage Identity of Somitic Vascular Smooth Muscle Cells

Vascular smooth muscle cell (VSMC) heterogeneity drives region-specific aortic pathologies, yet the roles of somite-derived lineages remain unclear. Utilizing Myf5 and MyoD lineage tracing alongside a smooth muscle-specific Myf5 conditional knockout model, we show that Myf5-deriv...

Distinct Molecular Landscape and Clinical Subtype of HPV-Positive Esophageal Squamous Cell Carcinoma

Background: This study aimed to investigate the prevalence of human papillomavirus (HPV) infection in Chinese patients with esophageal squamous cell carcinoma (ESCC) and its association with driver gene mutations (EGFR, KRAS, PIK3CA, PTEN), clinicopathological features, and progn...

Building Footprint Has a Stronger Land Surface Temperature Signal than Building Height across Global Cities

Abstract Urban heat is a growing environmental challenge as cities expand and densify. The thermal meaning of added built volume depends on whether volume is produced through larger building footprint, greater building height, or both. Using 2020 hottest-month land surface temper...

Postnatal sensorimotor experience causally shapes hemispheric specialization across motor and language networks

The functional organization of the human brain is shaped by the interplay between innate constraints and postnatal experience. Hemispheric specialization, as a fundamental organizing principle of brain function, raises unresolved questions about how postnatal experience shapes la...

Integrated postmortem brain transcriptomics identifies a five-gene Alzheimer’s disease-associated signature with a reproducible whole-blood CEBPB correlate

Transcriptomic profiling provides a systems-level view of Alzheimer’s disease (AD), capturing coordinated neuronal, glial, vascular, and immune-related changes. Yet the same breadth that makes transcriptomics informative also complicates interpretation because technical heterogen...

Stress-engineered 0.34 nm graphene memristors for low-power probabilistic computing

Memristors are promising for neuromorphic computing electronics, yet scaling is hindered by the difficulty of fabricating ordered nanoscale electrodes. Here, we report an angstrom-scale graphene-edge memristor with a geometrically defined 0.34 × 0.34 nm2 crossed-electrode area. K...

Managing through Closed Loops: the (Im)Possibility of Scale in China's Data-driven Governance

This paper examines what we call the (im)possibility of scale in China’s data-driven governance: while the promises of volume and growth of data suggest the possibility of governance at scale, our ethnography shows that it is impossible to realize in practice. Instead, on-the-gro...

Plasma interleukin-1 receptor antagonist in pediatric patients as a potential biomarker for sepsis-associated acute kidney injury: a cohort study

Our goal is to evaluate the potential of interleukin-1 receptor antagonist (IL-1Ra) as a biomarker for sepsis-associated acute kidney injury (SA-AKI). Specifically, we aim to explore the correlation between acutely elevated endogenous IL-1Ra and SA-AKI, and to identify the potent...

AI-assisted preoperative anesthesia evaluation workflow versus conventional bedside evaluation: a randomized controlled non-inferiority trial

Abstract Background Digital tools may improve the efficiency and standardization of preoperative anesthesia assessment, but evidence comparing AI-assisted workflows with conventional bedside evaluation remains limited. We compared ASA physical status classification concordance, d...

Building-Scale GeoAI for Short-Horizon Urban Inundation Prediction Under Sparse Labels and Distribution Shift: A Multi-Event Evaluation of Predictive Capability Boundaries in Taipei

Urban inundation forecasting in high-density cities is complicated by sparse incident labels, nonstationary rainfall, and changing sensing systems. Using Taipei as a case study, we develop a building-scale GeoAI decision-support prototype that integrates 30,421 Level of Detail 1...

Rotational stability and visual outcomes of toric implantable collamer lenses in eyes with horizontal and non-horizontal implanting orientation: an observational study

PURPOSE: To evaluate the short-term rotational stability and visual outcomes of the toric intraocular collamer lens (TICL) with horizontal and non-horizontal implantation orientation based on the Callisto eye system. METHODS: This observational study analyzed 77 eyes from 51 pati...

Semimetal-Interlayer-Engineered MoSe 2 /1T′-MoTe 2 /WSe 2 Heterostructure for Reconfigurable Rectification and Broadband Multifunctional Photodetection

Abstract Photodetectors based on two-dimensional (2D) van der Waals heterostructures have attracted considerable interest owing to their tunable electronic structures and efficient photoelectric conversion. However, simultaneously achieving low dark current, high photoresponse, a...

Integrative graph deep learning with directional decoding for robust gene regulatory network inference from single-cell transcriptomics

While gene regulatory networks (GRNs) are fundamental to understanding complex cellular mechanisms, the accurate inference from single-cell RNA-sequencing (scRNA-seq) data is hindered by the inherent noise, transcriptional dropout events, and dynamic nature of gene regulation. Cu...

Klebsiella pneumoniae-associated prostatic and bilateral seminal vesicle abscesses: a case report

Prostatic abscess is uncommon and potentially life-threatening. Simultaneous involvement of the prostate and both seminal vesicles is particularly rare. A 79-year-old Chinese man with poorly controlled type 2 diabetes mellitus, benign prostatic hyperplasia, and prostatic calcific...

Optimal Model Selection for Conformalized Robust Optimization

In decision-making under uncertainty, Contextual Robust Optimization (CRO) provides reliability by minimizing the worst-case decision loss over a prediction set. While recent advances use conformal prediction to construct prediction sets for machine learning models, the downstrea...