Fudan University

Hsc70-Mediated Targeting Chimeras for Targeted Protein Degradation via Chaperone-Mediated Autophagy

Abstract Despite the remarkable success of proteolysis-targeting chimeras (PROTACs), challenges such as limited applicability to certain cytosolic proteins, potential resistance risks, and off-target effects remain. Novel degradation strategies harnessing the autophagy/lysosome p...

Preliminary analysis of the materials and production of Shang Dynasty pottery from Zhengzhou Shang City

Zhengzhou City, the capital during the early Shang period, witnessed the Shang Dynasty’s early splendor. This study presents chemical and petrographic analyses of 154 pottery artifacts from the Erligang period, excavated in the Northern Area of Shuyuan Street. The findings reveal...

CGA-DTA: interaction-conditioned graph topology and cross-graph attention for drug--target affinity prediction

Drug–target affinity (DTA) prediction supports virtual screening in computer-aided drug discovery, but graph-based models still face two linked limitations. Adaptive-topology methods usually learn drug and protein graphs independently and merge them only at the prediction head, w...

Periodic Mesoporous Metal Oxides With Consistent Structure and Complementary Sensing Selectivity for Reliable Artificial Olfactory

The integration of functional materials and intelligent algorithms has endowed artificial olfactory systems with promising potential across various fields. Nevertheless, their accuracy and reliability in practical gas recognition remain constrained, primarily due to the unrefined...

The ALDW classification for fetal insular morphology: gestational norms and screening utility

To observe the changes in fetal insular morphology with gestational age using the transverse thalamic view, and to preliminarily explore the value of this approach in cases with nervous system abnormalities. Pregnant women between 18 and 34 weeks of gestation who attended the Pek...

Research on Optimization and Performance Analysis of Centrifugal Blood Pump Blade Parameters Based on Numerical Simulation

Abstract Objective: Taking the centrifugal blood pump as the research object, this study investigates the effects of blade type and blade wrap angle on pump performance, aiming to determine the optimal blade configuration and the appropriate range of the correlation coefficient φ...

Emil Frederick “Dutch” Wurzbach’s Memoir as a New Historical Source for Cormac McCarthy’s Blood Meridian

This article argues that the memoir of German immigrant Emil Frederick Wurzbach is an important but previously unrecognized historical source for Cormac McCarthy’s Blood Meridian. Wurzbach’s memoir records a sequence of mid-1800s adventures that parallel several locations and epi...

Modulation of the gut–liver axis via TMAO metabolism by Ramulus Mori alkaloids alleviates diabetic atherosclerosis

Diabetic atherosclerosis is a complex condition driven by intertwined metabolic disturbances including hyperglycemia, dyslipidemia, inflammation, and oxidative stress. The gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) has emerged as a key contributor that links...

Evolutions of Non‐oxygenated Compounds in Sunlit Subarctic Thermokarst Pond Surface Waters

Abstract With global climate change, ground subsidence caused by permafrost thawing leads to the formation of thermokarst ponds, where organics from eroding permafrost accumulate in part as dissolved organic matter (DOM). Surface waters were collected from two subarctic thermokar...

CoSAG-nf: A Scalable Nextflow Pipeline for Co-assembly, Optimization, and Interactive Visualization of High-Throughput Single-Cell Genomes

Abstract Motivation Single-cell amplified genomes (SAGs) are crucial for resolving intra-population microbial heterogeneity and accurately understanding the metabolic potential of microbial dark matter populations. However, SAGs generated through multiple displacement amplificati...

Nano-wrinkle waveguides for programmable polariton channeling

Abstract The intrinsic planarity of two-dimensional (2D) van der Waals (vdW) polaritonic media inherently limits the lateral confinement of vdW polaritons. Here, we transcend this geometric limit by introducing a deterministic strategy to engineer non-planar nano-wrinkle waveguid...

A case of hypertensive retinopathy developing during pembrolizumab treatment for intrahepatic cholangiocarcinoma

To report the first documented case of severe vision loss due to secondary hypertensive retinopathy associated with pembrolizumab therapy, thereby expanding the known spectrum of ocular toxicities from immune checkpoint inhibitors (ICIs). A 54-year-old woman with intrahepatic cho...

Care without value: institutional valuation and social reproduction

Reproductive labour is essential to social reproduction and capitalist economies, yet it remains persistently undervalued despite increasing institutional recognition. This article argues that reproductive devaluation cannot be explained solely by invisibility, unpaid labour, or...

Mammalian DNA maintenance methylation depends on histone but not PAF15 ubiquitination

In mammals, DNA methylation is an essential inheritable epigenetic modification maintained by the DNMT1-UHRF1 machinery in a UHRF1 E3 ubiquitin ligase-activity-dependent manner. UHRF1-catalyzed histone ubiquitination and PAF15 ubiquitination have been proposed to recruit DNMT1 to...

Integrated Multi‐Omics Analysis Identifies HVCN1 as a Potential Mediator in Neuroendocrine–Tumor Interactions in Colorectal Cancer

ABSTRACT Objective To investigate associations among sleep‐related features, neuroendocrine alterations, and colorectal cancer (CRC)‐related molecular programs, and to identify candidate genes involved in hypothalamus–tumor interactions. Methods NHANES data were analyzed to asses...

β‐ TP For Diagnosing CSF Leak After the Endoscopic Endonasal Approach Surgery for Sellar Tumors

ABSTRACT Objectives This study aimed to evaluate the diagnostic utility of quantitative beta‐trace protein (β‐TP) as an early biomarker for identifying postoperative cerebrospinal fluid (CSF) leaks following endoscopic endonasal approach (EEA) surgery for sellar tumors. Methods A...

Multisystem involvement in extramedullary plasmacytoma: diagnostic challenges and clinical implications—a case report

Extramedullary plasmacytoma (EMP) represents 3–5% of plasma cell tumors and is commonly found in the head and neck region, upper respiratory tract, and gastrointestinal tract. Cardiac and primary lung parenchymal involvement are extremely rare. This case report describes an unusu...

Restraining O–O Dimerization for Highly Reversible Oxygen Redox in a Sodium-Ion Layered-Oxide Cathode

Abstract Activating the oxygen redox reaction in sodium-ion layered-oxide cathodes is a promising approach to elevate the energy density. However, oxygen-redox cathodes typically suffer from poor reversibility. O–O dimerization has been recognized as the underlying driver of irre...

Uniqueness of Adapted Solutions to Scalar BSDEs with Peano-Type Generators

Abstract. A backward stochastic differential equation (BSDE) with a Peano-type generator is known to have infinitely many solutions when the terminal value is vanishing, and it is shown to have possibly multiple solutions even when the terminal value is not vanishing but nonnegat...

ESAM reduces sensitivity to anti-HER2 therapy in HER2-positive breast cancer by activating the mTOR pathway

Abstract Despite improved survival rates with dual trastuzumab and pertuzumab therapy, patients with HER2-positive breast cancer frequently experience disease progression due to intrinsic or acquired resistance. Elucidating the underlying mechanisms of resistance and identifying...