Fudan University

Dynamic reconfigurable metamaterials for coordinated heat and charge transport

Coordinated control of coupled heat and charge transport is fundamental to advanced thermoelectric energy conversion and management. Existing thermoelectric metamaterials are largely limited to static or steady-state functionalities. While spatiotemporal modulation has enabled dy...

Sensitive andReproducible SERS Profiling of Tumor-DerivedEVs via Uniform Microfluidic Nanobowl Arrays for Pancreatic CancerManagement

Abstract Tumor-derived extracellular vesicles (EVs) are promising liquid biopsy biomarkers, yet their clinical translation is hindered by the trade-off between enhancement and reproducibility of SERS-based detection. Here, we present a microfluidic SERS platform integrating plasm...

Nanocatalytic anti-inflammatory therapy for alleviating rheumatoid lesions with endothelial cell-derived hydrosilicene

Severe inflammatory damage of soft tissues and progressive bone destruction are hallmark features of rheumatoid arthritis (RA), in which over-activated neutrophils and excessive neutrophil extracellular traps (NETs) play a pivotal role during the early stages of the disease. Conv...

Digital therapeutics for mild adolescent idiopathic scoliosis: a protocol for a randomized controlled trial

Abstract Background Digital therapeutics (DTx), a new type of intervention presented in the last few years, can be used to provide patients with access to evidence-based therapeutic interventions using high-quality software programs to achieve the purpose of treating, managing, o...

Interface-shrunk regulated synthesis of asymmetric ultrafine mono-mesopore Nepenthes with tailored window

Asymmetric ultrafine mono-mesopore architectures with ultrasmall size, an open window, and unique physicochemical properties offer great opportunities in energy storage, yet their synthesis remains challenging. Inspired by the fast, unidirectional capture ability of Nepenthes, we...

Giant bulk photovoltaic effect driven by interfacial symmetry breaking in MoS2/Ta2NiSe5 heterostructures

Van der Waals (vdW) heterostructures offer a versatile platform for engineering unconventional bulk photovoltaic (BPV) effect through interfacial symmetry breaking. However, the coexistence of multiple photophysical mechanisms, driven by structural complexity, spontaneous charge...

Mitochondrial Omics in Macrophage Foam Cell Formation and Atherosclerosis

Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of death worldwide, with atherosclerosis serving as the core pathological mechanism driving ischemic heart disease, ischemic stroke, and peripheral artery disease. Macrophages play a central role in atherosclerosis...

MultidimensionalQuantitative Analysis of BiologicalResponses to DNA Nanoassemblies with Defined Structure and SurfaceChemistry

Abstract DNA nanoassemblies (DNs) have emerged as programmable platforms for biomedical applications; however, a quantitative understanding of how structure and surface chemistry jointly govern their biological behavior remains limited. Here, we establish a multidimensional analy...

Influence of many-body correlation and mixed-valence fluctuations on X-ray magnetic circular dichroism and resonant inelastic X-ray scattering spectra

X-ray magnetic circular dichroism (XMCD) and resonant inelastic X-ray scattering with magnetic circular dichroism (RIXS-MCD) provide unparalleled insights into the electronic and magnetic dynamics of complex materials. However, interpreting their spectra in mixed-valence systems...

Empowering PolymericMaterials Discovery by ArtificialIntelligence

Abstract Polymeric materials underpin modern technologies spanning energy storage, microelectronics, healthcare and sustainable manufacturing. Yet their rational design remains exceptionally challenging because material performance emerges from complex interactions among molecula...

Mechanism and plasticity of primitive pyroptosis

Pyroptosis is a proinflammatory form of regulated cell death across the tree of life. The gasdermin (GSDM) protein family functions as an evolutionarily conserved executioner of pyroptotic cell death by forming membrane pores. As the canonical activation mechanism, proteolytic cl...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Targeted biologics in muscle strength restoration and corticosteroid sparing for patients post-myasthenic crisis

Myasthenic crisis (MC) represents a life-threatening condition in patients with myasthenia gravis (MG). Despite a substantial reduction in in-hospital mortality for MC, full restoration of muscle strength and quality of life usually requires months or years. It remains unknown wh...

Symmetry-DependentUltrafast Spin Currents and THzEmissions in Noncollinear Antiferromagnetic Mn3Pt/Pt Heterostructures

Abstract Noncollinear antiferromagnets (NCAFs) provide a symmetry-rich platform for ultrafast spintronics, where light-driven spin currents are governed by both crystallographic orientation and magnetic symmetry. Here, we investigate femtosecond-laser-induced terahertz (THz) emis...

Blue Light Pollution and Ocular Surface Toxicity: p53-Mediated Ferroptosis in Corneal Epithelium Drives Dry Eye Pathogenesis

Purpose: This study investigated the molecular mechanisms underlying blue light-induced corneal epithelial toxicity. Methods: C57BL/6J mice were exposed to 460 nm blue light for 1, 2, or 4 weeks, whereas human corneal epithelial (HCE) cells were exposed for 15 or 30 min. RNA-sequ...

Effects of a neuromuscular warm-up on Y-balance, countermovement jump performance, and stroke velocity in adolescent table tennis players

Background/Objective Adolescent table tennis players are exposed to substantial physical and psychological demands during a period of ongoing growth and development, placing high demands on movement control, explosive performance, and sport-specific stroke execution. This study i...

The efficacy of stem cell therapy: cells or their microenvironment?

The therapeutic outcomes of stem cell therapy are determined not solely by cellular potency alone, but also by the receptiveness of the host microenvironment. Despite continuous progress in stem cell quality control and functional optimization technologies, inconsistent outcomes...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Two-wave modified cardiometabolic index change patterns and incident edentulism in Chinese adults: a longitudinal study from CHARLS

Abstract Objectives Complete tooth loss is a late-stage oral health endpoint that may reflect cumulative oral, systemic, behavioral, and social risk processes. We examined whether two-wave patterns of the modified cardiometabolic index (MCMI) from 2011 to 2015 were associated wit...

Star PolyelectrolyteCoacervates Enable Adaptive andRobust Enzyme Immobilization for Efficient Biocatalysis

Abstract Enzyme immobilization in solid porous supports often suffers from a trade-off among enzyme loading, mass transport, catalytic activity, and operational stability. Here, we report a liquid-like immobilization platform based on star polyelectrolyte coacervates (SPECs) form...