Fudan University

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Dental caries among 12-year-old adolescents in shanghai: a cross-sectional study on prevalence, severity, and associated risk factors

This study aimed to assess the prevalence, severity, and associated factors of dental caries in permanent teeth among 12-year-old adolescents in Shanghai, China. A cross-sectional study was conducted in 2021 among 1,305 adolescents from six randomly selected districts. Clinical e...

Cancer of unknown primary: the evolution of tissue of origin identification in the artificial intelligence era

Cancer of Unknown Primary (CUP) presents substantial diagnostic and therapeutic challenges owing to its heterogeneous nature and the absence of an identifiable primary tumor site. This review provides a structured search of the pathogenesis, epidemiological characteristics, and l...

Ferroelectric-EnhancedUltrafast Nonvolatile Floating-GateMemory

Abstract Floating-gate memory, as one of the most widely used nonvolatile memories for practical deployments, plays a significant role in modern electronics. However, its inherent speed limitations make it challenging to keep pace with the explosive growth of data generation and...

m6A ‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

ABSTRACT Background Ferroptosis is a non‐apoptotic form of cell death driven by lipid peroxidation. Although elevated lipid peroxidation has been linked to respiratory epithelial injury, its role in allergic rhinitis (AR) remains unclear. Therefore, in this study, we aimed to ass...

Genetic Predisposition and Pharmacological Effects Shape the Divergent Effects of Type 2 Diabetes on Atherosclerosis

Abstract Type 2 diabetes mellitus (T2D) increases the risk of atherosclerotic diseases, including coronary artery disease (CAD), but decreases that for abdominal aortic aneurysm (AAA), forming an intriguing diabetes-atherosclerosis paradox. We investigate how genetic underpinning...

Discovery andCharacterization of RP04340 : A Highly Potent and OrallyActive Pan-KRAS PROTAC Degrader

Abstract Targeting diverse KRAS mutations with a single agent remains a significant challenge in oncology. Here, we report the discovery and characterization of RP04340, a potent and orally bioavailable pan-KRAS PROTAC degrader. Starting with a structure-based pan-KRAS inhibitor...

Optimization and application of a tetracycline-inducible gene expression system in Kluyveromyces marxianus

Abstract Kluyveromyces marxianus is a promising microbial cell factory owing to its rapid growth, thermotolerance, broad carbon-source utilization, and food-safe status. Tetracycline (Tet)-inducible systems provide powerful means for precise gene regulation in various hosts. Howe...

Benchmarking RNA-seq with the Quartet and MAQC reference materials to establish best practices for accurate alternative splicing analysis

Previous limited characterization of short-read RNA-seq (srRNA-seq) accuracy in alternative splicing (AS) analysis due to methodological diversity and lack of reference standards, has left unclear how to achieve optimal performance—an issue increasingly critical with the rise of...

Molecular characteristics and formation pathways of organosulfur compounds: a comparative field study across contrasting atmospheric environments

Abstract. Organosulfur compounds (OrgSs), especially organosulfates (OSs), are ubiquitous aerosol components. However, the spatial, seasonal, and day-night variations of OrgS formation in polluted atmospheres remain poorly understood. Here, we monitored particulate OrgSs at an ur...

Agenda setting in mutual fund markets: news, social media, and fund marketing in China

We analyze the effects of social attention on investment behavior. Using an original dataset covering 3,782 funds and over 240,000 news articles, we show that media attention, separated into traditional news media and social media, is associated with greater fund visibility and n...

Synchronous ReactiveOxygen Species Scavenging andImmunomodulation for Autoimmune Uveitis Therapy by a MannosylatedBiomimetic Nanocloak

Abstract Autoimmune uveitis is a recurrent, vision-threatening inflammatory disease that demands precise and ongoing treatment. However, current therapies have limitations in ocular targeting, in controlling reactive oxygen species (ROS), and in regulating key inflammatory pathwa...

Parent–child connectedness and its associations with sexual risk behavior and outcomes among young people: a systematic review and meta-analysis

Significant disparities in the sexual and reproductive health of young people persist globally. Although previous systematic reviews and meta-analyses have largely focused on the effects of parenting practices, such as parent–child communication and parental monitoring, on sexual...

Virtues, vices, and valuation: Marketization and moral evaluation in China

To advance understanding of the relationship between marketization and morality in China, this study deploys a conjoint experimental design that generates hypothetical profiles composed of randomized combinations of virtues and vises across a heterogeneous set of moral domains. T...

Playing with Fire, Losing the Drive: Bidirectional Links Between Problematic Smartphone Use and Grit Dimensions

This study examined bidirectional longitudinal associations between grit dimensions (consistency of interest [CI] and perseverance of effort [PE]) and problematic smartphone use (PSU) and tested cognitive flexibility as a mediating mechanism. A sample of 1,641 Chinese university...

An N-acetylated daropeptide modulates nematode development

The symbiotic bacterium Photorhabdus is a rich source of bioactive secondary metabolites that mediate tripartite interactions with nematodes and insect hosts. However, natural products of ribosomal origin remain largely underexplored within this ecological niche. Here, we report...

Why does El Niño develop slowly but decay rapidly

El Niño events typically develop slowly but decay rapidly, yet the processes driving this phase asymmetry remain insufficiently quantified. Here we diagnose the mixed-layer heat budget over integration depths ranging from 30 to 100 m and introduce a depth-resolved diagnostic fram...

Age-related and temporal patterns of blood pressure among male industrial workers in Shanghai: evidence from occupational health examinations, 2013–2023

Occupational health examinations provide repeated and standardized health data for workers under surveillance and may offer a valuable resource for long-term blood pressure monitoring. However, evidence on age-related and temporal patterns of blood pressure among occupational pop...

Adaptive drop-deployable visible light communication-based underwater sensing probe

Covering under 0.1% of the ocean’s surface, coral reefs support about 30% of all marine life. Nevertheless, this fragile ecosystem is experiencing an extinction threat due to overexploitation and anthropogenically driven pressure. High-frequency and widespread observations are es...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...