Fudan University

P1.073. The Evaluative Value of Quality of Life in Neoadjuvant Treatment for Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background While neoadjuvant therapy contribute to tumor downstaging and improves resectability rates, effective tools for predicting treatment response remain limited. This study investigated quality of life b...

P1.059. Calcium-Channel Blocker Use and Survival After Neoadjuvant Therapy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Calcium-channel blockers (CCBs) are commonly prescribed for cardiovascular disease. Beyond hemodynamic effects, experimental studies suggest that CCBs may modulate tumor biology through interference...

P1.245. Real-Time AI-Based Thoracic Duct Recognition During Thoracoscopic Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Thoracic duct injury during thoracoscopic esophagectomy may result in postoperative chylothorax, a serious complication associated with increased morbidity. However, intraoperative id...

Social determinants of health substantially enhance identification of high-risk CKM syndrome progression: a longitudinal prediction study based on data from CHARLS

Cardiovascular-Kidney-Metabolic (CKM) syndrome represents a critical public health challenge, with a large portion of the Chinese population classified as CKM Stage 2. While the impact of Social Determinants of Health (SDoH) on chronic disease is known, their longitudinal role in...

P1.058. Angiotensin System Inhibitors and Outcomes After Neoadjuvant Therapy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Renin angiotensin system signaling has been implicated in tumor growth, angiogenesis, immune modulation, and responses to cytotoxic and radiation-based therapies, yet clinical effects appear heteroge...

P1.057. Early Recurrence After Neoadjuvant Therapy and Esophagectomy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Despite improved interventions with radical esophagectomy accompanied by perioperative systematic therapy, recurrence remains frequent in locally advanced esophageal squamous cell carcinoma (ESCC). A...

Multi‐Stimuli Responsive Phosphate Hybrids With Visible‐Light‐Excited Dual‐Mode Afterglow Toward Multifunctional Applications

ABSTRACT Dual‐mode afterglow emission is a notable photoluminescent phenomenon in which materials exhibit prolonged luminescence via thermally activated delayed fluorescence (TADF) and phosphorescence. Developing such dual‐mode materials through a simple preparation process is in...

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

ABSTRACT Catheter‐related bloodstream infection (CRBSI) is an important clinical problem that causes significant mortality and excess economic cost. Recent epidemiological trends indicate a shift in CRBSI pathogens from Gram‐positive to Gram‐negative bacilli, among which Pseudomo...

Deep Cavitand Mediated Selective Aerobic Oxidative Cyclization of Thiols to Cyclic Disulfides

Abstract A mild supramolecular template strategy is reported for the selective synthesis of medium- to macrocyclic disulfides via aerobic oxidative cyclization of α,ω-dithiols in aqueous media. The water-soluble deep cavitand CV-1 serves as a multifunctional platform that synergi...

Topology-Driven Sodium Storage and Conversion in Covalent Fullerene Networks

Abstract Fullerene network is an emergent two-dimensional (2D) carbon allotrope in which C60 molecules are covalently bonded to form a quasi-hexagonal pattern (qHP). The intermolecular covalent bonding significantly reshapes the intrinsic electronic structure of the C60 units, le...

Evaluationof 18F-FPPA as a PositronEmission Tomography Radioligand for Imaging CSF1R in LPS-Induced RatModel of Neuroinflammation

Abstract Noninvasive detection of microglia is crucial for monitoring their spatiotemporal dynamics and facilitating early medical intervention during the prodromal stages of these neuroinflammatory diseases. Colony-stimulating factor 1 receptor (CSF1R) is a promising imaging bio...

ElectrochemiluminescenceMicroscopy

Abstract Electrochemiluminescence (ECL) microscopy is an emerging imaging technology that combines electrochemistry with optical microscopy. It operates without external light excitation, effectively eliminating photobleaching, phototoxicity, and scattered light noise, and thus e...

Microplastics in pediatric asthma: Clinical associations with disease severity

Background Respiratory exposure to microplastics (MPs) is increasingly recognized as a potential contributor to chronic airway disease, but the MPs burden in children with asthma and its relationship to disease remain poorly defined. Methods In this cross-sectional study, sputum...

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

Abstract Immune checkpoint blockade (ICB) has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment. Yet, a major barrier to response is that tumor cells are epigenetically reprogrammed to resist immunogenic cell death, particularly pyroptosis. To elucidate how t...

PassBitNet: low-resource password guessing using 1-Bit quantized transformers

Large language models (LLMs) demonstrate exceptional accuracy in password-guessing tasks, but their massive memory cost, high computational demands, and high duplicate rates severely limit deployment in resource-constrained scenarios. This paper introduces the 1-bit/1.58-bit quan...

Metrnl Reduces Thrombosis and Acute Myocardial Injury Through Inhibition of Platelet Activation via CD36 Receptor Degradation

BACKGROUND: Metrnl (Meteorin-like) is a secreted protein that plays a pivotal role in regulating insulin sensitivity, angiogenesis, and atherosclerosis. The circulating Metrnl levels are mainly derived from the endothelium and associated with atherosclerosis and arterial thrombot...

Structural characteristics of the temporomandibular joint in temporomandibular joint disorder syndrome: a preliminary cross-sectional study based on MRI

Temporomandibular joint disorder syndrome (TMD) is a prevalent oral-maxillofacial condition. The Diagnostic Criteria serve as a widely used diagnostic framework for TMD with high specificity, yet its sensitivity requires further optimization. In contrast, magnetic resonance imagi...

Pressure-gated flexible nanofluidic memristor based on a probe-punctured PDMS membrane

A flexible nanofluidic memristor is demonstrated based on a polydimethylsiloxane (PDMS) membrane containing a single nanopore formed by probe puncturing and controlled by external pressure. A PDMS prepolymer with a base-to-curing agent ratio of 10:1 is cast and cured into a thin,...

Dynamic reconfigurable metamaterials for coordinated heat and charge transport

Coordinated control of coupled heat and charge transport is fundamental to advanced thermoelectric energy conversion and management. Existing thermoelectric metamaterials are largely limited to static or steady-state functionalities. While spatiotemporal modulation has enabled dy...

Superconductivity from doping symmetric mass generation insulators: application to La3Ni2O7 under pressure

Abstract We investigate the bilayer nickelates as a platform to realize the symmetric mass generation (SMG) insulator, a featureless Mott insulator that arises due to the Lieb-Schultz-Mattis (LSM) anomaly cancellation in bilayer spin-1/2 lattice systems. Through a single-orbital...