Fudan University

Klebsiella pneumoniae-associated prostatic and bilateral seminal vesicle abscesses: a case report

Prostatic abscess is uncommon and potentially life-threatening. Simultaneous involvement of the prostate and both seminal vesicles is particularly rare. A 79-year-old Chinese man with poorly controlled type 2 diabetes mellitus, benign prostatic hyperplasia, and prostatic calcific...

Mifepristone versus other interventions for the prevention of pregnancy in reproductive-age women using emergency contraception

RATIONALE: Emergency contraception uses drugs or intrauterine devices to prevent pregnancy after unprotected intercourse. Understanding the effectiveness, safety, and acceptability of the various methods available is critical for reproductive healthcare providers and their patien...

Synchronization of topological signals in higher-order adaptive multilayer network

The study of synchronization in complex systems has recently been revolutionized by incorporating higher-order interactions through simplicial complexes. Building in particular upon the higher-order Kuramoto model, which considers oscillators on nodes, links, and higher-dimension...

Mid Holocene ecosystem peak and late Holocene shift to littoral refugia in an arid Altai lake: non-pollen palynomorph record

This study reconstructs the local environmental conditions of Lake Tarkhata (Altai Mountains) during the Middle and Late Holocene based on the analysis of non-pollen palynomorphs preserved in lacustrine sediments. A total of approximately 60 NPP morphotypes were identified, inclu...

HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma

The Regulator of Cullins 1 (ROC1) or RING box protein-1 (RBX1) is an essential component of the largest multiunit Cullin-RING ubiquitin ligase (CRL). Previous studies demonstrated that ROC1 is frequently overexpressed in multiple malignancies, which predicts advanced cancer stage...

Preoperative prediction of MSI status in gastric cancer based on CT and radiomics: a multicenter study

To develop a non-invasive prediction model and assess its predictive power of microsatellite instability (MSI) status in gastric cancer (GC). This retrospective study included 1,012 GC patients from three hospitals during January 2019 and January 2023. Patients from hospital C we...

Omni2Web: Benchmarking Audiovisual Website Development

32 pages, 6 figures, 18 tables.

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction

Significance: Copper is an essential redox-active micronutrient, but failure of copper compartmentalization can convert it from a catalytic cofactor into a source of oxidative, proteotoxic, and mitochondrial stress. Neutrophils are a plausible target of this transition because th...

Classification-aware conditional diffusion-augmented criss-cross graph transformer for EEG-based emotion recognition

Reliable electroencephalogram (EEG)-based emotion recognition remains challenging because labeled recordings are limited, noisy, non-stationary, and strongly subject dependent. This paper proposes a classification-aware conditional diffusion-augmented criss-cross graph transforme...

Central Limit Theorems for Random Walks on the 3-Regular Tree

We present four related limit theorems for random walks, beginning with a one-dimensional nearest-neighbour walk and its absolute value. The absolute value has a normal limit after centring when the drift is nonzero, and a half-normal limit when the drift is zero. The main part o...

Central Limit Theorems for Random Walks on the 3-Regular Tree

We present four related limit theorems for random walks, beginning with a one-dimensional nearest-neighbour walk and its absolute value. The absolute value has a normal limit after centring when the drift is nonzero, and a half-normal limit when the drift is zero. The main part o...

Genetic origin and forensic analysis of han populations from four districts in Shanghai, China, based on Y-chromosome STR and SNP markers

Y-short tandem repeats (STRs) and Y-single nucleotide polymorphisms (SNPs) on the Y chromosome are genetic markers unique to men. They are widely used in identification, forensic medicine and paternal lineage tracing. Because of their strict paternal genetic characteristics, they...

Orbital Hybridization Dominates the Enhanced Polarization Response Arising From Interlayer Coupling in Ti 3 C 2 T x MXene

ABSTRACT Interlayer engineering plays a crucial role in the electronics, electromagnetics, and microwave engineering properties of two‐dimensional materials. However, the lack of clear clarification of the complex coupling mechanisms has become a key bottleneck in guiding further...

Interleukin-15-armed trivalent mRNA vaccine elicits robust and durable protection against lethal mpox and vaccinia virus challenges in mice

The global re-emergence of mpox virus (MPXV) poses a critical threat, particularly to vulnerable immunocompromised populations, thus highlighting an urgent need for effective and safe interventions. In this study, we developed and compared three mRNA-LNP candidates: a trivalent c...

Are the blue and the green natural allies? Mapping the public foundations of just transition worldwide

A Just Transition, with its dual goals of environmental sustainability and social equity, has gained global prominence and has been adopted as a formal policy agenda by governments and intergovernmental organizations. While broad and meaningful public support for both goals is cr...

Activating Aqueous Multivalent Metal–Sulfur Electrochemistry via Kinetic Promoter

Abstract Sulfur-based aqueous batteries for sustainable energy storage have the advantages of material abundance, low cost, and high theoretical capacity. While aqueous multivalent metal–sulfur electrochemistry is effective in suppressing sulfide dissolution due to its low solubi...

Preliminary analysis of the materials and production of Shang Dynasty pottery from Zhengzhou Shang City

Zhengzhou City, the capital during the early Shang period, witnessed the Shang Dynasty’s early splendor. This study presents chemical and petrographic analyses of 154 pottery artifacts from the Erligang period, excavated in the Northern Area of Shuyuan Street. The findings reveal...

Gate-Tunable Ambipolar Rubrene/WSe2 Polarization-Sensitive Photodetectors

Abstract Organic−inorganic heterojunctions have emerged as a promising platform for high-performance photodetectors, yet most existing works integrate organic crystalline or amorphous thin films with 2D inorganic semiconductors, which are fundamentally limited by high defect dens...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

The effect of HIF-PHIs on anemia in non-dialysis-dependent CKD patients: a systematic review and network meta-analysis

This study compared the effects of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) and erythropoiesis-stimulating agents (ESAs) on anemia in non-dialysis-dependent chronic kidney disease (ND-CKD), with emphasis on follow-up duration and iron-metabolism markers....