Fudan University

Hydrogel-EmpoweredInterfacial Reactive Hydrogen onCopper Enables Selective Nitrate-To-Ammonia Electrocatalysis

Abstract Precise control of interfacial reactive hydrogen is crucial for improving the selectivity of proton-coupled electron transfer reactions in electrocatalysis. In the nitrate electroreduction to ammonia reaction, a fundamental trade-off is identified for copper (Cu)-based c...

The efficacy of stem cell therapy: cells or their microenvironment?

The therapeutic outcomes of stem cell therapy are determined not solely by cellular potency alone, but also by the receptiveness of the host microenvironment. Despite continuous progress in stem cell quality control and functional optimization technologies, inconsistent outcomes...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Star PolyelectrolyteCoacervates Enable Adaptive andRobust Enzyme Immobilization for Efficient Biocatalysis

Abstract Enzyme immobilization in solid porous supports often suffers from a trade-off among enzyme loading, mass transport, catalytic activity, and operational stability. Here, we report a liquid-like immobilization platform based on star polyelectrolyte coacervates (SPECs) form...

Influence of Water Molecule Adsorption and H2 ReductionTreatment on Acid Sites of WO3 with the (002)Crystal Facet Studied by Solid-State NMR Spectroscopy

Abstract In-depth investigations of the influence of water molecule adsorption and H2 reduction treatment on surface acid sites of metal oxides are vital to elucidate the mechanism of catalytic reaction and to optimize the design of catalysts. By introduction of different amounts...

On the Schubert calculus of the quantum K-theory for partial flag manifolds: a 3d A-model perspective

A bstract We further investigate the 3d gauged linear sigma model (GLSM)/ quantum K-theory correspondence for partial flag manifolds X ≡ Fl( k ; n ). This is a 3d uplift of the 2d GLSM/quantum cohomology correspondence with the 3d theory compactified on $$ {\mathbb{R}}^2\times {S...

2-methylbutanal remodels arachidonic acid metabolism and antitumor immunity through ENO1 in colorectal cancer

Active aldehydes are increasingly recognized as bioactive metabolites, but their roles in tumor immune regulation remain poorly defined. In colorectal cancer (CRC), prostaglandin metabolism contributes to immune suppression, whereas its upstream metabolic regulators are incomplet...

Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis

Background: Humoral immunity targeting hepatitis B virus (HBV) surface antigen (HBsAg) is critical for viral clearance. However, the phenotypic, repertoire, and metabolic features of HBsAg-specific B cells in chronic hepatitis B (CHB) remain incompletely defined. Methods: HBsAg-s...

Noninvasive 3D mapping of tissue stress using reverberant shear wave

Abstract Mechanical stress is a fundamental aspect of soft tissues that influences cellular behavior and tissue integrity, yet noninvasive imaging of stress in vivo remains a major challenge. Conventional magnetic resonance elastography (MRE) measures tissue stiffness but not str...

Dentofacial Orthopedic Treatment vs. Adenotonsillectomy in Children with Mild to Moderate OSA and Mandibular Retrognathia: A Randomized Controlled Trial

Background/Objectives: Pediatric obstructive sleep apnea (OSA), particularly when accompanied by mandibular retrognathia, presents as a complex, multifactorial condition. Dentofacial orthopedic treatment (DOT) has gained increasing clinical attention; however, high-level evidence...

Guest-DrivenFlexibility in a Hydrogen-Bonded OrganicFramework for NH3 Capture

Abstract Ammonia (NH3) capture and low-energy release remain a critical challenge in adsorptive separation. Herein, we report a guest-driven flexible hydrogen-bonded organic framework (HOF), designated FDU-HOF-7, constructed from 1,3,5-benzenetricarboxylic acid. The as-synthesize...

MXene-Based Conductive Microneedle Patch Promotes Diabetic Wound Healing by Regulating Oxidative Stress and Immune Microenvironment

Abstract Excessive reactive oxygen species (ROS) generation and the release of inflammatory mediators create a pathological microenvironment in diabetic wounds, severely impairing the healing process. Coupling endogenous electric fields has shown great therapeutic potential for i...

A study on the predictive value of preoperative MRI-based radiomics for postoperative neurological function in patients with ossification of the posterior longitudinal ligament

This study proposes to develop an integrative predictive model that synergistically combines quantitative radiomic features, established clinical risk parameters, and advanced machine learning methodologies to forecast postoperative neurological functional outcomes in patients di...

Phosphoantigen-driven dissociation of butyrophilin oligomers activates γδ T cells

γδ T cells represent a promising avenue for cancer immunotherapy. The Vγ9Vδ2 T-cell receptor (TCR), which is expressed by the predominant subset of γδ T cells, responds to phosphoantigen (pAg)-engaged butyrophilins (BTNs) on various cancer cells. However, the molecular mechanism...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Individual autistic traits may affect scene-based categorical representation: evidence from an ERP study

Contextual visual scenes facilitate semantic processing through top-down prediction, but it remains unclear how autistic traits modulate this cross-modal integration. We examined scene-word semantic integration in 30 neurotypical adults using event-related potentials (ERPs) and r...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

Clinicopathologic and prognostic value of HER2 alterations in non-small cell lung cancer

Abstract Background Human epidermal growth factor receptor 2 ( HER2 ) alterations represent emerging therapeutic targets in non-small cell lung cancer (NSCLC). However, the clinicopathological and prognostic values of HER2 mutations, amplification, and over expression remain poor...

Ag-iPyramidSERS Enables Single-Particle Detectionof Sub-200 nm Nanoplastics in Real Samples

Abstract The detection of nanoplastics smaller than 200 nm is critical because of their potential to cross biological barriers, yet it remains a significant analytical challenge in complex environmental matrices due to weak signals and matrix interference. Here, we developed an o...

Microfluidic engineering of CeO2/Peptide nanosheet-integrated bioactive hydrogel microspheres for multi-enzymatic biomimetic catalytic therapy of osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease characterized by chronic inflammation and oxidative stress-induced cartilage degeneration, yet effective disease-modifying therapies remain limited. Herein, we report a CeO 2 /peptide nanosheet (CeP)-integrated hydrogel microsph...