Fudan University

Characterization of SPP1 + macrophages and their correlation with resistance to neoadjuvant chemotherapy in colorectal cancer liver metastasis

Neoadjuvant chemotherapy (NAC) for colorectal cancer liver metastasis (CRLM) remains a major clinical challenge, with outcomes varying widely among patients, yet the mechanisms that drive therapeutic resistance remain incompletely understood. In this study, we integrated single‑c...

Associations between vaccine misinformation and influenza vaccine uptake: a population-based interrupted time-series study in China

Abstract Vaccine misinformation is linked to vaccine hesitancy, yet real-world evidence of its association with vaccine uptake remains limited. Most existing studies rely on self-reported intentions or experimental designs, offering little insight into population-level behavioura...

Microstructured Metal Electrodeposition at a Micellar Brush‐Decorated Interface

ABSTRACT Metal electrodeposition is usually interfered by stochastic ion arrival, local field amplification, and uncontrolled crystal growth, rendering it difficult to translate molecular‐level interfacial design into prescribed mesoscale architectures. Here, we report that surfa...

MXene‐Doped P(VDF‐TrFE) Piezoelectric Spring‐Structured Devices for Vibration Sensing and Sleep Monitoring

Driven by the rapid development of artificial intelligence and the internet of things, flexible piezoelectric polymers and smart sensors have emerged as core research focuses on flexible electronics. Polyvinylidene fluoride (PVDF) and its copolymer P(VDF‐TrFE) stand out for outst...

TRIM3 functions as a tumor suppressor and predicts prognosis in triple-negative breast cancer: a multi-omics study with clinical cohort validation

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis and limited treatment options. Tripartite motif-containing protein 3 (TRIM3), an E3 ubiquitin ligase, has been implicated as a tumor suppressor in several cancers; however, its biologi...

Effect of Dyadic Care Types on Knowledge‐Attitude‐Practice Relationship in Coronary Heart Disease Caring Dyads: A Moderated Mediation Model

ABSTRACT This study aimed to validate the knowledge‐attitude‐practice (KAP) model in coronary heart disease (CHD) patients and their family caregivers, and examine the moderating role of dyadic care types. Data were collected from 281 patient‐caregiver dyads, and moderated mediat...

Combined Accommodation and Fusional Training Paradigm Versus Prism Correction for Small-Angle Acute Acquired Comitant Esotropia: A Cohort Study

This study explored 6-month ocular alignment and visual function outcomes associated with a combined accommodative and fusional training paradigm and compared them with outcomes observed after prism correction in patients with small-angle acute acquired comitant esotropia. This p...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

Protocol for rolling circle amplification-based nanopore sequencing of eccDNA from cell and plasma samples

Extrachromosomal circular DNAs (eccDNAs) can drive copy number variation and genomic rearrangements and act as mobile regulators of gene expression. Here, we detail a protocol for eccDNA identification from cell and plasma samples. We describe steps for sample preprocessing with...

Identification and Characterization of EmNag, a Novel β-1,2-N-Acetylglucosaminidase from Elizabethkingia meningoseptica

Abstract N-Acetylglucosamine exists in various glycoforms and linkage patterns within organisms, playing a crucial role in numerous vital biological processes. The signal of β-1,2-N-acetylglucosamine is a key component within complex biantennary N-glycans on the cell surface, lea...

The Picard group of the Baily–Borel compactification of the moduli space of quasi-polarized K3 surfaces and generalizations

Abstract We investigate the Picard group of the Baily–Borel compactification of orthogonal Shimura varieties. In particular, we show that the Picard group of the Baily–Borel compactification of the moduli space of quasi-polarized K3 surfaces is isomorphic to ℤ. Notably, this cont...

Entanglement-induced resilience of quantum dynamics

Quantum many-body devices suffer from imperfections that destabilize dynamics and limit scalability. We show that the dynamical growth of entanglement can intrinsically protect generic quantum dynamics against coherent noise and local perturbative noise. Through rigorous theoreti...

Targeting the ENO1 metabolic checkpoint via microenvironment-responsive nanotherapeutics promotes postinfarction cardiac repair

Myocardial infarction (MI) triggers persistent inflammatory dysregulation, wherein macrophages undergo glycolytic reprogramming and adopt an inflammatory phenotype that impairs cardiac repair. However, the specific metabolic drivers underlying post-MI macrophage dysfunction remai...

Different concentrations of atropine in children with high myopia: a 2-year multicenter double-blind, randomized controlled trial

High myopia in children risks irreversible visual impairment, yet optimal interventions remain debated. This multicenter double-blind, randomized-controlled trial aims to evaluate the effect and safety of different atropine eyedrops for myopia control in children with high myopia...

ESTIMATION OF HETEROGENEOUS PANEL DATA MODELS WITH AN APPLICATION TO PROGRAM EVALUATION

This article studies panel data models with two-dimensional unobserved slope heterogeneity and interactive fixed effects. We propose a two-step approach to estimate the parameters in the model. We apply the proposed model to estimate heterogeneous treatment effects at both indivi...

Industrial Practice of LLM-Based Test Case Carving and Assertion Generation (Experience Paper)

Enterprise regression testing for microservice systems is often constrained by incomplete or outdated documentation. In practice, QA engineers frequently rely on real execution traffic to reconstruct business scenarios; however, turning raw traffic into replayable regression test...

Towards Iterative End-to-End Software Development: A Feature-Driven Multi-agent Framework

Recent advances in large language model agents offer the promise of automating end-to-end software development from natural language requirements. However, existing approaches largely adopt linear, waterfall-style pipelines, which oversimplify the iterative nature of real-world d...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

RESTOR: Automated Test Oracle Generation for RESTful APIs via Reinforcement Learning

Modern REST API testing faces a critical challenge in defining reliable test oracles, particularly in agile industrial environments where formal specifications (e.g., OpenAPI) are frequently missing or outdated, and historical execution logs are unavailable for newly deployed end...

RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.

BACKGROUND: Cisplatin-based chemotherapy serves as a fundamental approach in the treatment of cervical cancer; however, its effectiveness is often hindered by the development of drug resistance, which presents a significant obstacle in clinical practice. METHODS: studies were car...