Fudan University

Tuning Water Transport in Subnanometer‐Sized Artificial Water Channels

ABSTRACT Water transport through nanochannels is not only essential for biological functions but also holds promise for the development of advanced flow sensors and membranes. In this study, a series of artificial water channels with subnanometer‐sized pores and tunable hydrophil...

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Abstract Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, i...

From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease

Panvascular diseases (PVDs) stand as the leading cause of global mortality, necessitating a paradigm shift from local anatomical repair to the systemic restoration of vascular homeostasis. While intravascular optical imaging has revolutionized diagnosis, it remains a passive obse...

Artificial intelligence empowers full-stack histopathological diagnosis and prognosis of renal cell tumor: a multi-center study with external validation

BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detect...

Preoperative HbA1c and postoperative day 1 fasting plasma glucose are associated with early glycemic improvement after transsphenoidal surgery in patients with acromegaly and preoperative dysglycemia: a retrospective cohort study

Dysglycemia is common in acromegaly and may improve after transsphenoidal surgery, but factors associated with early postoperative glycemic improvement are unclear. We aimed to identify perioperative factors associated with glycemic improvement at first follow-up, focusing on pre...

Adenosine 2A receptor drives microglial efferocytosis to accelerate white matter repair and functional recovery after stroke

Although reperfusion therapy effectively restores blood flow to occluded brain arteries after ischemic stroke, many patients develop persistent white matter injury, a major contributor to long-term neurological disability. Currently, there are few approved clinical therapies that...

Tazemetostat combined PD-1 inhibitor achieving prolonged survival in primary proximal epithelioid sarcoma: a case report and review of the literature

Abstract Background Epithelioid sarcoma (ES) is a rare mesenchymal tumor categorized into proximal (axial) and classical (distal) types. In general, proximal ES come alone with limited treatment options and poor prognosis. Herein, we present the case of a proximal ES treated with...

Mitochondria-Targeted Lonidamine Hydrogels for Postsurgical Elimination of Glioblastoma

The high recurrence rate of glioblastoma after surgical resection and conventional chemotherapy remains a major obstacle to effective treatment. Mitochondria-targeted long-acting local chemotherapy represents a promising therapeutic strategy to tackle this dilemma. In this study,...

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...

Short- and long-term exposures to elevated temperatures influence weight status among young children: A secondary analysis of multi-longitudinal datasets from Australia and New Zealand

Climate change and childhood obesity are major global health threats that share common upstream determinants. However, evidence on the associations between ambient temperature and childhood obesity remains limited. This study aimed to investigate the associations between temperat...

Estimation of Partially Linear Panel Data Model With Double/Debiased Machine Learning

ABSTRACT This paper studies the estimation of partially linear static/dynamic panel models with two‐way fixed effects. The nonlinear component is estimated by machine learning. We extend the cross‐sectional Double/Debiased Machine Learning (DML) framework to panel data to deal wi...

Impact of oral nutritional supplements on chemotherapy tolerance and overall survival in postoperative colorectal cancer patients undergoing chemotherapy.

BACKGROUND AND OBJECTIVES: The primary objective of this study was to evaluate the efficacy of oral nutritional supplements (ONS) on chemotherapy tolerance and long-term survival outcomes in postoperative colorectal cancer patients undergoing chemotherapy. METHODS AND STUDY DESIG...

Burdens of pancreatic cancer from 1990 to 2021 and projection to 2050 in China: findings from the 2021 global burden of disease study

<title>Abstract</title> Background Pancreatic cancer in China exhibits high incidence and mortality rates, imposing a significant disease burden. It is essential to clarify the trends in pancreatic cancer from 1990 to 2021 and predict future trends up to 2050, which can provide v...

Gliomas grading prediction using multicenter 3T Magnetic Resonance Spectroscopy

Abstract Background Magnetic Resonance Spectroscopy (MRS) is a non-invasive imaging technique that detects various metabolites in brain tissues, making it essential for the grading of brain gliomas. MRS measures key metabolites such as N-acetyl-aspartate (NAA), choline (Cho), and...

Institutional hiring strategies and research performance: alumni versus non-alumni faculty in business schools

Faculty recruitment strategies, particularly the debate over hiring alumni versus non-alumni candidates, represent a longstanding concern in higher education management. This study investigates whether alumni or non-alumni faculty achieve superior research performance, drawing on...

Platforms Reshape Embeddedness? Platformization and Bilateral Embeddedness of the Chinese Audiovisual Industry

This study investigates the transformation of embeddedness relationships in China’s audiovisual industry during platformization. Based on interviews with thirty-five audiovisual professionals in the Yangtze River Delta region, the study finds that under the dual administration of...