Institution
Fudan University
Recent research
- BiologyOpen access
Atherosclerosis is a lipid-driven, chronic inflammatory disease of large and medium-sized arteries that underlies major cardiovascular events and remains a leading cause of mortality and morbidity worldwide. It is characterized by the progressive formation of lipid-rich plaques w...
- BiologyOpen access
Abstract Background Mitochondrial DNA (mtDNA) mutations cause multisystem disorders often involving gastrointestinal dysfunction. However, the mechanisms governing the selection against mutant mtDNA and the specific impact of pathogenic mtDNA mutations on intestinal epithelial ce...
- Physics & SpaceOpen access
Large-scale array of squeezed light and synchronization using atomic vapor
Abstract Quantum light sources such as squeezed light are essential for quantum information science and technologies, but the scalable production of multiple beams of them remains a challenge. Here, we experimentally demonstrate a novel approach to the generation of a large spati...
- Health & MedicineOpen access
Abstract Cerebrospinal fluid contributes to homeostasis in the central nervous system, but how its dynamics are altered in glioblastoma is unclear. We find that glioblastoma drives leptomeningeal perivascular fibrosis that is associated with impaired fluid transport and clearance...
- Physics & SpaceOpen access
Unveiling non-Hermitian band structures with non-Bloch supercells
Abstract Real-valued band structures underpin the analysis of periodic Hermitian systems and are well established experimentally. By contrast, non-Hermitian systems feature complex band structures, in which energy and momentum acquire imaginary parts, enabling phenomena that defy...
- Engineering & Technology
Abstract Conventional aqueous electrolytes are often restricted by a narrow electrochemical stability window (∼1.23 V), while water-in-salt electrolytes alleviate this limitation at the cost of excessive salt consumption and sluggish Li+ transport. To address this trade-off, poly...
- AI & ComputingOpen access
Interpolation and Inverse Problems in Spectral Barron Spaces
Abstract. Spectral Barron spaces, which quantify the absolute value of weighted Fourier coefficients of a function, have gained considerable attention due to their capability for universal approximation across certain function classes. By establishing a connection between these s...
- BiologyOpen access
An ideal in vitro system to study somitogenesis is induced presomitic mesoderm (UiPSM); the regulatory pathways of this system are not well understood. Here, integrated multi-omic and functional analyses were performed to elucidate the roles of Wnt signaling and EPZ5676 in UiPSM...
- BiologyOpen access
Longitudinal Analysis of Urine Metabolomics in Preterm Infants Based on UHPLC-MS/MS Technique
Background: The metabolic characteristics of preterm infants in the early postnatal period are closely linked to their growth and development. Investigating the corresponding metabolic changes that occur during the early postnatal maturation process of preterm infants may help im...
- Health & MedicineOpen access
Abstract Background: periodontitis is a prevalent chronic inflammatory disease driven by oral microbiota dysbiosis, with profound oral and systemic impacts that impair healthy aging. Conventional screening methods are invasive and delay early detection, while microbiota-based str...
- Health & Medicine
ABSTRACT Background Acute kidney injury (AKI) during vancomycin treatment remains a rare occurrence in adult patients with haematological malignancies (HMs). The objective of this multicentre study was to investigate the incidence and risk factors for AKI during vancomycin treatm...
- Engineering & TechnologyOpen access
For every continuous, strictly positive probability density $f$ and every $B = 2^b \ge 4$, we construct a $B$-ary companded scalar quantizer with a calibrated reconstruction map whose box average in the quantile domain equals the inverse compander. Uniform dithering therefore yie...
- Engineering & TechnologyOpen access
For every continuous, strictly positive probability density $f$ and every $B = 2^b \ge 4$, we construct a $B$-ary companded scalar quantizer with a calibrated reconstruction map whose box average in the quantile domain equals the inverse compander. Uniform dithering therefore yie...
- Health & Medicine
Summary Lower levels of sitting time were associated with a lower risk of severe asthma exacerbations in adults. High levels of physical activity eliminated the detrimental association of sitting time with severe asthma exacerbations in adults.
- BiologyOpen access
Abstract Histone synthesis is tightly coupled with DNA replication to ensure proper chromatin assembly and genome stability. To meet the sharply elevated demand for histones during S phase, eukaryotic cells employ specialized mechanisms to translate replication-dependent (RD) his...
- Health & MedicineOpen access
Cardiovascular-Kidney-Metabolic (CKM) syndrome represents a critical public health challenge, with a large portion of the Chinese population classified as CKM Stage 2. While the impact of Social Determinants of Health (SDoH) on chronic disease is known, their longitudinal role in...
- Health & Medicine
P1.245. Real-Time AI-Based Thoracic Duct Recognition During Thoracoscopic Esophagectomy
Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Thoracic duct injury during thoracoscopic esophagectomy may result in postoperative chylothorax, a serious complication associated with increased morbidity. However, intraoperative id...
- Health & MedicineOpen access
Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background While neoadjuvant therapy contribute to tumor downstaging and improves resectability rates, effective tools for predicting treatment response remain limited. This study investigated quality of life b...
- Health & Medicine
P1.059. Calcium-Channel Blocker Use and Survival After Neoadjuvant Therapy for Locally Advanced ESCC
Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Calcium-channel blockers (CCBs) are commonly prescribed for cardiovascular disease. Beyond hemodynamic effects, experimental studies suggest that CCBs may modulate tumor biology through interference...
- Health & Medicine
Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Renin angiotensin system signaling has been implicated in tumor growth, angiogenesis, immune modulation, and responses to cytotoxic and radiation-based therapies, yet clinical effects appear heteroge...