Fudan University

Gap-tuned exceptional skin effect in non-Hermitian flat bands

Flat-band states in Hermitian systems exhibit compact localization in the bulk due to geometric or symmetry constraints, while non-Hermitian skin effects drive state accumulation at boundaries via asymmetric lattice hoppings. Despite extensive efforts devoted to studying these tw...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Discordant Interleukin-27 (IL-27) Subunit Transcription in Human Sepsis Exposes a Molecular-Attribution Gap

Background/Objectives: Interleukin-27 (IL-27) is an obligate EBI3–p28 heterodimer, yet sepsis studies commonly measure and target the axis as a single entity. We tested whether both subunit transcripts are coordinately induced in septic monocytes and whether the axis has function...

Learning stochastic dynamics and cell-fate landscapes from single-cell snapshots via optimal transport

The temporal dynamics and stochasticity of gene expression are critical to cell fate decisions, yet integrating snapshot omics data across multiple time points remains a major challenge. Here, we introduce DiffusionOT, a dynamic machine learning framework that infers cellular tra...

Metabolomic Signatures Uncover Domestication-Driven Hypoxia Tolerance in Common Carp (Cyprinus carpio)

Hypoxia represents a pervasive selective pressure in aquaculture systems, prompting aquatic organisms to develop distinct tolerance strategies through diverse physiological and biochemical responses. The common carp (Cyprinus carpio), a species characterized by extensive geograph...

Selection and prediction of targeted serum protein biomarkers for early diagnosis of esophageal squamous cell carcinoma

Achieving early diagnosis of esophageal squamous cell carcinoma (ESCC) is crucial for reducing the disease burden. This study aims to identify potential serum protein biomarkers associated with the early diagnosis of ESCC in two independent populations and further develop diagnos...

Cobalt–Copper Single-Atom Alloy Catalyst for Electrochemical Nitric Oxide Reduction to Ammonia

Abstract Electrochemical reduction of nitric oxide (NO) to ammonia (NH3) offers a more sustainable pathway. However, significant challenges remain in achieving high NH3 Faradaic efficiency, industrially relevant production rates, and downstream purification to meet commercial sta...

High-pressure variable-temperature sum-frequency vibrational spectroscopy for in situ molecular probing of gas-hydrate formation at aqueous interface

Here, we describe a high-pressure, variable-temperature sum-frequency vibrational spectroscopy (SFVS) apparatus designed for in situ, surface-specific measurements of aqueous interfaces during gas-hydrate formation. The apparatus integrates an ultra-clean gas-handling system, a s...

Tuning H2O-Engaged Redox Reaction Pathway via Water Orientation in Aqueous Batteries

Abstract Aqueous battery research has long focused on ionic behavior during reactions but has largely neglected the essential role of reactive water, hindering the mechanistic understanding and limiting breakthroughs in battery performance. Herein, we establish an H2O-engaged per...

Temporal Evolution and Vertical Distribution of Size-Resolved Aerosol Composition and Mixing State within the Boundary Layer Using an Unmanned Aerial Vehicle

Abstract Characteristics of individual particles and aerosol mixing state strongly influence atmospheric chemistry, radiation, and cloud formation yet remain poorly constrained. Here, we investigated the spatiotemporal evolution of size-resolved particle composition in a coastal...

S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma

Background Neutrophils are increasingly recognised as immunosuppressive drivers of hepatocellular carcinoma (HCC), yet their persistence in the oxidative, lipid-rich tumour microenvironment remains poorly understood. Objective To elucidate the metabolic and molecular programmes t...

Cross-Omics Identification and Validation of PCSK9 as a Candidate Molecule Associated with Aortic Dissection and Negative Remodeling After TEVAR

Background: Negative aortic remodeling after thoracic endovascular aortic repair (TEVAR) remains a major challenge in patients with type B aortic dissection (TBAD). This exploratory study aimed to integrate human aortic tissue transcriptomic data with serum proteomic profiles fro...

Global pandemic preparedness before and during COVID-19: an assessment of changes and financing

COVID-19 exposed weaknesses in health-system readiness and renewed interest in how reported preparedness changed across countries. This paper describes changes in formal preparedness capacity before and during the pandemic, presents health-expenditure and pandemic-response accoun...

Networks and genome-resolved analyses reveal persistent particle-mediated coupling between prokaryotes and eukaryotic plankton

Interactions between bacterioplankton and eukaryotic plankton are often inferred from short-lived algal blooms, leaving it unclear whether coupling persists under natural seasonal variability and which traits sustain it. We conducted seasonal sampling of coastal seawater over an...

A New Method for Optimizing Spinal Canal Cross-Sectional Area During Laminoplasty: Lateral Mass Gutter

Study Design Retrospective Cohort Study. Objective To propose a new technique named “lateral mass gutter” and investigate its role in augmenting spinal canal cross-sectional area (SCA) during laminoplasty. Methods This study included 105 patients who received cervical laminoplast...

Butterfly Proboscis‐Inspired Water‐Welding Strategy for Hollow‐Walled Hydrogel 3D Stents With Ultrahigh Mechanical Support Capacity

ABSTRACT Hydrogels have emerged as promising candidates for next‐generation implantable biomedical stents. However, the scalable fabrication of hydrogel three‐dimensional (3D) stents with sufficient mechanical support remains a major challenge, owing to the intrinsic flexibility...

Semantic dependency network approach to the lexico-semantic impairment of Mandarin-speaking patients with probable Alzheimer’s dementia

Background Population ageing has increased dementia prevalence in China, and language impairments represent a prominent behavioral manifestation of cognitive decline.Aims Compared with healthy controls (HCs), this study aims to explore mainland Chinese probable Alzheimer’s dement...

Climate extremes are associated with crime dynamics in China

While the societal implications of climate extremes have received considerable attention, the specific associations with crime dynamics remain unclear. Leveraging a unique nationwide crime panel dataset (over 8.6 million) parsed via large-scale textual analysis, we capture detail...

Chimeric antigen receptor (CAR)-T cell therapy for solid tumors in pediatric patients: current breakthroughs, dilemmas, and strategies

Chimeric antigen receptor (CAR)-T cell therapy has demonstrated substantial clinical efficacy in pediatric hematologic malignancies; however, its application in pediatric solid tumors remains investigational and is constrained by substantial biological and clinical challenges. Ke...

Predicting left-ventricular recovery and characterizing Cardiorenal risk after Transcatheter aortic valve replacement: A routine-data phenotyping and prediction-model study

Background Ejection fraction (LVEF) underpins risk stratification before transcatheter aortic valve replacement (TAVR), yet it does not indicate whether an impaired ventricle will recover once the stenosis is relieved, or what drives death in high-risk patients. We asked whether...