Fudan University

Microbial architects of the lung tumor niche: integrating intratumoral and lung cancer-associated microbiome

Lung cancer (LC) remains one of the leading causes of cancer-related morbidity and mortality worldwide. Increasing evidence suggests that both the lung cancer-associated microbiome and the intratumoral microbiome are important components of the tumor ecosystem and contribute to c...

Terahertz reflection spectroscopy of palm leaf manuscripts with spatially contextualized analysis

Reflection-mode THz-TDS of spatially heterogeneous palm-leaf manuscripts reflects contributions from both material response and measurement geometry. We present a workflow using five duration-labeled specimens (0–160 d; one specimen per label), each measured at left, center, and...

Strong tropical cyclones have a more gradual increase trend through interaction with ocean subsurface

Understanding changes in global tropical cyclone (TC) intensity and their long-term trends is critical for enhancing societal resilience. Given their disproportionate impacts, shifts in strong TCs, which are defined here as Category 4 and above, are of particular concern. We exam...

Mutations in EnvZ, KPC, and OmpK36 contribute to the evolution from ceftazidime-avibactam heteroresistance to stable resistance in carbapenem-resistant Klebsiella pneumoniae

Antibiotic heteroresistance, an unstable phenotype wherein a minority-resistant subpopulation coexists with a majority-susceptible population, can evolve to stable resistance following in vivo antibiotic exposure, thereby substantially increasing the risk of treatment failure. Ho...

Dynamic Photoexcited Oxygen Vacancies beyond Static Defects Achieve 1.66 V Zn‐Air Battery

ABSTRACT Oxygen vacancies are widely introduced into electrocatalysts to boost the oxygen reduction reaction (ORR) in Zn‐air batteries, yet their dynamic behavior under operando illumination remains largely unexplored. Herein, we demonstrate that initial synthetic oxygen vacancie...

In Vivo Chemical Cross-Linking Coupled with Reversed-Phase Co-Fractionation Mass Spectrometry Enables Protein Complex Analysis

Abstract Understanding protein–protein interactions (PPIs) and the architecture of protein complexes is essential for elucidating cellular functions and drug action mechanisms. Co-fractionation mass spectrometry (CF-MS) has emerged as an effective tool for analyzing protein compl...

Gut microbiota dysbiosis correlates with reduced drug exposure in patients with multidrug-resistant tuberculosis

Although systemic exposure to anti-tuberculosis agents is critical for therapeutic efficacy, substantial inter-individual variability of drug exposure persists despite standardized dosing. Emerging studies suggest that the gut microbiota may influence drug metabolism and host pha...

Early inflammatory response is associated with antibiotic treatment outcomes in acute phlegmonous appendicitis: a retrospective cohort study

Acute phlegmonous appendicitis is considered an intermediate inflammatory subtype between uncomplicated and complicated appendicitis. Although nonoperative management is increasingly accepted for uncomplicated appendicitis, evidence for phlegmonous appendicitis remains limited. T...

Efficient ISAR imaging of ship-ocean scenes using improved bidirectional ray tracing with BVH acceleration

This paper proposes an improved bidirectional ray tracing algorithm based on BVH (Bounding Volume Hierarchy) acceleration for ISAR imaging of complex ocean scenes. The proposed method was employed to obtain the frequency-domain electromagnetic scattering characteristics of compos...

Frequency-Offset-Estimation-Assisted Transformer Neural Equalization for a 4.6 km Optical-Heterodyne RoF–Wireless OFDM Link

To address the issues of subcarrier orthogonality loss and inter-carrier interference (ICI) caused by carrier frequency offset (CFO), this paper proposes and experimentally validates a frequency offset estimation (FOE)-assisted dual-domain Transformer equalizer within an advanced...

Learning in Lost-Sales Inventory Systems with Stochastic Lead Times and Random Supplies

Supply uncertainty, characterized by stochastic lead times and random supply quantities, has attracted increasing attention from academia, industries, and governments, particularly in the aftermath of the COVID-19 pandemic. In this paper, we consider the problem of managing lost-...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Debugging Functionality-Twisting Translations by LLMs via Differential Testing with Bayesian Prior

Code translation, as a challenging and fundamental task, is increasingly relying on large language models (LLMs). However, LLMs often give seemingly plausible but fallacious translations, misleading and even deceptive to debugging developers. We propose tHinter, an automated appr...

Monomer-biased manufacture of industrial-scale colloidal photonic films

Complex functions in nature arise from the ordered assembly of simple building blocks. Transformation of colloidal aggregates into industrial-scale photonic crystals under rapid ambient conditions remains challenging owing to high energy barriers and limited assembly control. In...

Exploring baryon semileptonic decays through polarization and entanglement

Abstract The unitarity of the Cabibbo–Kobayashi–Maskawa (CKM) matrix is a cornerstone of the standard model (SM). Precise tests of this unitarity require independent determinations of its elements, such as | V us |, which governs the transition between strange and up quarks. Curr...

Flexible Photochromic Synaptic Devices for UV Perception and Spatiotemporal Encoding

ABSTRACT Flexible synaptic devices with short‐term optical dynamics offer promising building blocks for low‐power and visualized neuromorphic perception, yet introducing time‐dependent weight update and visual readout remains highly challenging. Herein, we establish a universal s...

Towards an Asian registry of wrongful convictions

Wrongful convictions represent a persistent yet unevenly documented problem across Asian criminal justice systems. While international research has identified common factors contributing to known wrongful convictions, systematic information about wrongful conviction cases in Asia...

Adaptive Evolution of Community Response Organizations in Public Health Emergencies: A Grounded System Dynamics Case Study from China

Public health emergencies often unfold over extended periods and place sustained pressure on community-level governance, particularly when demands for supplies, information, medical access, and daily support exceed routine service capacity. This study examines how community respo...

MARC-Net: A Modality-Availability-Aware Robust Change Network for Missing-Optical Bi-Temporal Optical–SAR Change Detection of Reclaimed Cropland

Reliable monitoring of reclaimed cropland is hindered when one optical acquisition is unavailable or degraded. We formulate missing-modality bi-temporal optical–SAR change detection and propose the Modality-Availability-Aware Robust Change Network (MARC-Net), a new architecture t...

The 2025 CHINET surveillance report on bacterial resistance in China

Abstract This study assessed the antimicrobial susceptibility of clinical bacterial isolates collected from Chinese medical institutions in 2025. Antimicrobial susceptibility testing was performed on isolates from 80 hospitals using disk diffusion or commercial automated systems...