Fudan University

Fluorescent protein ticker tape (FPTT): Multiplexed recording of transcriptional dynamics in living cells and in vivo

Recording and real-time imaging of promoter activities are critical for deciphering signaling cross-talk, but technologies for simultaneously capturing multiple transient events in living cells are lacking. Here, we design fluorescent protein–based ticker tapes (FPTT) for multipl...

Revisiting HAIC and systemic treatment for initially diagnosed HCC with major portal vein (Vp3/4) tumor thrombosis

Hepatocellular carcinoma (HCC) with major portal vein tumor thrombosis (PVTT) has a dismal survival expectancy. The treatment for HCC with major PVTT remains challenging. The aim of the study was to revisit the survival outcomes and safety of locoregional hepatic arterial infusio...

Investigation on Ti0.94Zr0.08Cr1.0Mn0.6−xFe0.4+x (x = 0, 0.1, 0.2, 0.3, 0.4) Alloys for 25 MPa Hydrogen Compression Materials

For hydrogen refueling stations, metal hydride compressors offer a safe and efficient alternative to mechanical systems. This work systematically investigates Ti0.94Zr0.08Cr1.0Mn0.6−xFe0.4+x (x = 0, 0.1, 0.2, 0.3, 0.4) alloys for primary hydrogen compression targeting 25 MPa. All...

Data distribution impacts the performance and generalisability of contrastive learning-based foundation models of electrocardiograms

Contrastive learning is a widely adopted self-supervised pretraining strategy, yet its dependence on cohort composition remains underexplored. We present Contrasting by Augmented Patient Electrocardiograms (CAPE) foundation model and pretrain on four cohorts (n = 5,203,269), from...

Stochastic Maximum Principle for Square-Integrable Optimal Control of Linearly Growing Stochastic Differential Systems Subject to a Quadratically Growing Cost Functional

Abstract. With Ekeland’s variational principle, we prove a general stochastic maximum principle (SMP) for square-integrable optimal control of linearly growing stochastic differential systems subject to a quadratically growing cost functional. The diffusion coefficient is allowed...

An East Asian blood eQTL meta-analysis highlights ancestry-matched eQTL resources for complex-trait genetics

Abstract Expression quantitative trait loci (eQTLs) link genetic variation to gene regulation and complex traits, yet population-scale blood eQTL resources remain limited in East Asian populations. We mapped cis-eQTLs in 1,005 Chinese individuals and meta-analysed them with a Jap...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Presynaptic mechanisms of glycine-modulated synaptic transmission at central synapses

Glycine is a major inhibitory neurotransmitter in the central nervous system and plays a critical role in synaptic transmission and plasticity. Although its postsynaptic actions mediated by glycine receptors (GlyRs) are well characterized, the presynaptic mechanisms by which glyc...

Projected burden of humid-heat on paediatric asthma in Shanghai under climate change scenarios: A time-series study

Climate change is intensifying the frequency and severity of extreme heat events. While the impact of temperature on respiratory health is well-documented, the synergistic effects of combined heat and humidity are less clear, especially for children, a population with heightened...

The effects of norepinephrine infusion combined with goal-directed fluid therapy on delayed graft function in patients undergoing kidney transplantations: study protocol for a multicenter randomized controlled trial

Chronic kidney disease presents a formidable challenge to global healthcare systems. With ongoing advancements in surgical techniques, kidney transplantation has emerged as a principal therapeutic modality for individuals afflicted with end-stage renal disease, markedly enhancing...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Barriers and facilitators to physical activity promotion by healthcare professionals: an umbrella review

Abstract Background Physical inactivity is consistently associated with the incidence of chronic diseases. The clinical environment may be an ideal setting to promote physical activity (PA). To date, substantial efforts have been made by multiple institutions to encourage PA prom...

The impact of local government debt on leverage adjustment speed: evidence from a quasi-natural experiment of local governmental debt governance reform

Purpose This study takes China’s 2014 local government debt governance reform as a quasi-natural experiment. It aims to examine how the reform affects corporate leverage adjustment speed, and explores whether it eases the structural imbalance of corporate debt between state-owned...

From informal hawkers to state employees: newspaper vendors’ labor incorporation and identity reconstruction in Shanghai, 1911–1956

This article examines the transformation of Shanghai’s newspaper vendors from marginalized hawkers to state workers between 1911 and 1956. Vendors operated in a guild-based, hierarchical system dominated by powerful wholesalers, functioning largely beyond state control through in...

Cryo-EM structures of Cdr1 reveal snapshots of substrate transport and diverse inhibitor recognition

In Candida albicans —a World Health Organization fungal priority pathogen—overexpression of the adenosine triphosphate (ATP)–binding cassette transporter Cdr1 drives multidrug resistance. We present seven cryo–electron microscopy structures capturing substrate entry and expulsion...

Statistics-enhanced cross-domain perception network for spaceborne infrared tiny ship detection

Spaceborne thermal infrared remote sensing is indispensable for maritime surveillance and ship management, yet detecting tiny ships in infrared imagery remains challenging due to small object sizes, weak textures, and strong structured clutter. To address these challenges, we pro...

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

OBJECTIVE: This study was undertaken to assess long-term efficacy, safety, and tolerability of adjunctive cenobamate in an open-label extension (OLE) of a randomized, double-blind, placebo-controlled, dose-response study (NCT04557085; YKP3089C035 [Study C035]) in Asian patients w...

Hi-Cformer enables multiscale chromatin contact map modeling for single-cell Hi-C data analysis

Abstract Single-cell Hi-C captures the three-dimensional organization of chromatin in individual cells and provides insights into fundamental genomic processes such as gene regulation and transcription. While analyses of bulk Hi-C data have revealed multi-scale chromatin structur...

Decoding hypoxia-driven microenvironment remodeling in bladder cancer reveals TPST1 as a key driver of metastasis

Hypoxia is a key feature of the bladder cancer tumor microenvironment, but its cellular organization, prognostic value, and functional effectors remain incompletely defined. Here, we integrated single-cell RNA sequencing, bulk transcriptomic cohorts, machine-learning modeling, im...

ATAC: Anchor-tail aware context parallelism for LLM training

Large language model training commonly relies on multidimensional parallelism, including data, tensor, pipeline, and context parallelism, to support long-context and large-scale workloads. However, real pretraining corpora consist of highly heterogeneous variable-length samples,...