Fudan University

Gold Nanourchins Potentiate Intravesical Chemotherapy by Accelerating Drug Internalization within a Short Instillation Window

Abstract Intravesical chemotherapy is a standard adjuvant treatment for nonmuscle-invasive bladder cancer after transurethral resection, but its efficacy is limited by drug exposure resulting from urinary dilution and physiological voiding. Most current delivery strategies aim to...

Multi-objective optimization of B-spline parameterized film holes: Cooling effectiveness, thermal stress and flow resistance

Film cooling is widely used in turbine blades and combustors, serving as an indispensable key technology for gas turbines and aero-engines. Previous research on film cooling optimization has predominantly adopted single-objective approaches centered exclusively on cooling effecti...

Stabilizing Multi-Stranded Helical Supercylinders via Synergistic Effect of A- and C-Block Bidispersity in Frustrated ABC/ABC Binary Blends

Abstract Helical supercylindrical structures are one type of unique morphologies formed by “frustrated” linear ABC triblock copolymers, which exhibit more intricate geometrical features than straight cylinders. Their stabilization mechanism, especially the feasibility of stabiliz...

Suppression of meiotic double-strand break formation in somatic cells by DREAM factors TCX5/6 maintains genome stability

Meiotic recombination in reproductive cells is initiated by DNA double-strand breaks (DSBs) and requires the expression of meiosis-specific genes, yet how the transcription of those genes is regulated in either meiotic or somatic cells remains unclear. Here, using a representativ...

A Machine Learning Model With Temporal Validation for Predicting Walking Ability in Nontraumatic Spinal Cord Injury

BACKGROUND: Walking ability is the priority for spinal cord injury (SCI) patients. Nontraumatic SCI (NTSCI) is increasing with aging populations, yet its prognosis remains understudied. Early predictionF using admission clinical indicators could facilitate decision-making and reh...

Sex-Specific Associations of Gestational OPE Exposure with Offspring Digit Ratio: A Birth Cohort Study

Abstract The effect of prenatal organophosphate esters (OPEs) exposure on offspring reproductive development and the potential role of the placenta remain unclear. We investigated the associations of prenatal OPE exposure with the second-to-fourth digit ratio (2D:4D) and the medi...

Condensation Sink Efficiency of Atmospheric Particles Regulated by Their Chemical Compositions and Hygroscopicity

Abstract Condensation sink (CS) from atmospheric pre-existing particles is a crucial limiting factor for the occurrence of new particle formation (NPF). However, intense NPF events occur frequently in polluted urban areas despite high CS levels. Here, to address this discrepancy,...

Entropy-Guided BIST Instruction Set Compression for Auto-CP Embedded Flash Testing

Embedded Flash chip probing (CP) testing in an automotive Microcontroller Unit (MCU) involves long test flows and numerous test items. Conventional BIST-based testing relies on step-by-step Automated Test Equipment (ATE) instruction configuration, status polling, and result reado...

Efficient Cascade Abiotic Synthesis of Sugar From CO 2

ABSTRACT The capability of producing sugar compounds from carbon dioxide (CO 2 ), ideally based on abiotic systems, suggests an artificial, scalable strategy to provide potential solutions for both food and environmental issues. In this work, we report an inorganic, abiotic pathw...

Evolving Roles in Decision-Making About Human Papillomavirus Vaccination Among Middle School Girls in Yinzhou of Ningbo, Eastern China: A Qualitative Study With a Focus on the Educational Sector as an Influential Player

Human papillomavirus (HPV) vaccination is endorsed by the World Health Organization for cervical cancer prevention, but it is not part of China’s national immunization program. This study explores the roles of various key interest holders in HPV vaccination decisions, focusing on...

Large‐Scale, Homogeneous Solution Crystallization of 2D Covalent Organic Frameworks with Integrated Crystallinity and Solubility for Ultrafast Noble Metal Recovery

ABSTRACT Solution‐processable covalent organic frameworks (COFs) are crucial for advancing practical applications, yet traditional top‐down exfoliation into solvophilic nanosheets suffers from low efficiency and limited scalability. This study presents a large‐scale homogeneous c...

Impact of Backbone Fluorination on Self-Assembly and Mixed Conduction of Isoindigo-Based Polymers

Abstract Fluorination is a common method to induce backbone planarity in semiconducting polymers via noncovalent interactions that effectively lock the rotation of single bonds along the backbone. Often explored in dry-state devices, fluorination of isoindigo polymer backbones in...

Intelligent Inverse Design of Meta‐Absorbers Based on Reversible Deep Learning

ABSTRACT Optical meta‐absorbers are artificially engineered materials capable of trapping light in a highly controllable manner, rendering them attractive for a wide range of applications. Artificial intelligence provides powerful tools for the efficient design of such complex st...

Turbulence-Invariant Polarization Readout via Spin-Dependent Angular Mapping

Abstract Atmospheric turbulence disrupts spatial coherence in free-space optical (FSO) systems, fundamentally limiting the reliable extraction of optical information encoded in intensity, phase, or spatial degrees of freedom. While polarization is intrinsically immune to scalar t...

Unraveling membrane protein conformational landscapes: Enhanced sampling, membrane regulation, and artificial intelligence–assisted simulation

Membrane proteins undergo functionally essential conformational transitions that couple local chemical events and changes in the membrane environment to large-scale structural rearrangements. These transitions are often difficult to capture with conventional molecular dynamics (M...

FeBr3-Catalyzed Aromatization-C–O Bond Cleavage Process for Construction of Aryl-Substituted Prostaglandin Skeleton

Abstract Prostaglandins exhibit therapeutic potential in multiple diseases and the incorporation of aromatic rings into their side chains can often enhance their corresponding biological activities. Although more than 20 kinds of drugs are currently used in clinical practice, the...

Decoding availability of services: interplay of income inequality and intergovernmental transfers on child protection

This study investigates the effect of income inequality on the availability of child protection services at the municipality level in Finland, by considering the moderating role of intergovernmental transfers. Utilising macro-level panel data from 293 municipalities over the peri...

Screening strategies for the early detection of non-cardia gastric cancer in low- to moderate-prevalence regions: Asia-Pacific gastroesophageal cancer congress consensus 2026

Abstract Background Gastric cancer (GC) remains a major global health burden, and early detection is essential for improving patient outcomes. Although GC screening has been widely implemented in East Asian countries with a high disease burden, the optimal screening strategy for...

Pd-Sensitized SnO2@WO3 Nanosheets via Cluster-Nucleus Coassembly: Enhanced Hydrogen Spillover for High-Efficiency H2 Sensing

Abstract The risk of hydrogen explosions in industrial and hydrogen energy facilities presents serious safety threats. An inherent trade-off between response magnitude and response/recovery kinetics plagues chemiresistive H2 sensors: monocomponent materials are incapable of concu...

Targeted Perturbation of Mitochondrial Energy Metabolism via Thermoelectric Nanoflowers for Enhanced Cuproptosis Echoed With Immunotherapy

ABSTRACT Cuproptosis, a novel anti‐cancer mechanism, holds significant potential for triggering sequential immunotherapy to enhance anti‐cancer efficacy. However, this cascade effect is often limited by copper efflux mechanisms mediated by the copper‐transporting ATPase (ATP7B),...