Fudan University

Boundedness of polarized log Calabi–Yau fibrations with bounded bases

We investigate the boundedness problem for log Calabi–Yau fibrations whose bases and general fibers are bounded. We prove that the total spaces of log Calabi–Yau fibrations are bounded in codimension one after fixing some natural invariants, which confirms a conjecture of Birkar...

Iridium-Catalyzed Asymmetric Hydrogenation of Pyridazine Salts under Batch and Flow

Abstract Herein, we report an [Ir(COD)Cl]2/(R)-SunPhos-catalyzed asymmetric hydrogenation of pyridazine salts to construct chiral hexahydropyridazines. The reaction tolerates a wide range of substituents, delivering products in up to 97% yield with 97% ee under mild reaction cond...

On integrable structures on non–compact boundaries in three–dimensional gravity

We study three-dimensional Einstein gravity with negative cosmological constant on non-compact spatial boundaries within the Chern-Simons formulation. Using an exact fluid/gravity correspondence, we derive a closed radial flow equation for the quasi-local stress tensor and show t...

Microscopic Understanding of V-Shaped Pits Induced Quantum Barriers and Localized-State Luminescence in High-Indium-Content InGaN/GaN Multiple-Quantum-Well LEDs

Abstract In this study, microstructural characterization with high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), variable-temperature steady-state and time-resolved photoluminescence (PL), PL-excitation spectral measurements, and calculations ba...

Multilevel phylogenetic inference of syntactic harmony in Indo-European

Abstract One of the most well-established typological universals is that languages tend to order the grammatical head and its dependents consistently. This harmonic principle has been attributed to cognitive benefits that facilitate language processing and learning efficiency. Ho...

Virological Events During Immune Checkpoint Inhibitor Therapy: A Multi-Source Evaluation

Background/Objectives: Virological findings during immune checkpoint inhibitor (ICI) therapy may represent viral loss of control, pre-existing infection, tumour biomarkers, or infection after immune-related adverse event (irAE)-directed immunosuppression. Distinguishing these pos...

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

PSMα contributes to Egr1-dependent early neutrophil recruitment and host defense in a murine model of Staphylococcus aureus pneumonia

Abstract Background Staphylococcus aureus ( S. aureus ) pneumonia is associated with substantial morbidity and mortality. Neutrophils play a central role in host defense against bacterial infection and are significantly increased in the lungs during S. aureus pneumonia. However,...

Warm-sector heavy rainfall over the eastern China plains: identification, characteristics, and precursor dynamic signals

Abstract. Warm-sector heavy rainfall (WSHR) features small spatial scales, posing critical forecast challenges, while its fractional contribution to regional heavy rainfall and its short-term precursors remain poorly quantified. Drawing on 2021–2025 warm-season (June–September) o...

Frequency-specific oscillations track parallel processing of linguistic structural and lexical-semantic information from perception to decision

The ability to perceive linguistic features is essential for language comprehension, yet how our brains dynamically recognize, integrate and process distinct linguistic features is still controversial. Here, we employ magnetoencephalography to examine the spatiotemporal organizat...

Nebulized lidocaine for preventing postoperative pulmonary complications in major abdominal surgery

Despite the lung-protective ventilation strategy, high incidence of postoperative pulmonary complications (PPCs) after major non-cardiac surgery remains a major concern in the perioperative care due to high morbidity and mortality. The study aimed to evaluate the efficacy and saf...

Repeatable Velocity Fine Structure of Lightning K‐Leaders From a Single VHF Interferometer Made Three‐Dimensional

Abstract K‐processes re‐illuminate lightning channels at speeds of order 10 7 m s −1 , but measuring their three‐dimensional (3‐D) propagation velocity has required multi‐station systems available at few sites. An error‐isomorphism range inversion upgrades a single very‐high‐freq...

Second-order interactions induce anti-phase synchronization between the left and right suprachiasmatic nucleus

In the dynamical study of neural networks, pairwise coupling has long been regarded as the classical paradigm for describing interactions between neurons. However, recent studies have revealed the existence of more complex higher-order interactions among neurons, and this group c...

AP2M1 promotes TNBC progression by stabilizing EGFR through inhibition of lysosomal degradation

Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous malignancy, with 50–80% of cases exhibiting elevated EGFR expression. Dysregulated endocytic trafficking contributes to sustained receptor signaling and tumor progression, suggesting endocytosis as a potentia...

The cardiovascular–liver–metabolic syndemic and mortality and life expectancy: two prospective cohort studies

Cardiovascular disease (CVD), metabolic dysfunction–associated steatotic liver disease (MASLD), type 2 diabetes mellitus (T2DM), and obesity frequently coexist and share overlapping pathophysiologic mechanisms, collectively constituting a cardiovascular–liver–metabolic (CLM) synd...

BHunter: Generating Blind-Spot Driving Scenarios for Robustness Testing of Perception Systems

For widespread deployment of autonomous driving systems (ADS), perception robustness plays a fundamental role. However, maintaining robust perception performance remains a significant challenge, especially under occlusion-rich conditions, known as blind-spot driving scenarios. In...

Two‐Dimensional Framework Materials as Building Blocks for Next‐Generation Intelligent Biointerfaces

ABSTRACT The convergence of neural interfaces, wearable bioelectronics, and human‐machine interaction is driving intelligent biointerfaces capable of sensing and responding to neural, physiological, and biomechanical signals. Realizing this vision demands a substantial advance in...

Evaluation of 68Ga Labeling Strategies and Thermostability of HER2-Targeted Nanobody NB46

Abstract The HER2-targeted nanobody NB46 was evaluated for labeling strategy flexibility and thermostability. Random and site-specific 68Ga labeling strategies were compared. Both conjugates exhibited high HER2 affinity, comparable to unmodified NB46. Cellular uptake, pharmacokin...

Persistent Hypoperfusion on Post‐Recanalization Digital Subtraction Angiography Perfusion Maps in Anterior Circulation Large Vessel Occlusion

Background Despite high recanalization rates with endovascular thrombectomy for large vessel occlusion stroke, a large proportion of patients remain disabled. This study aims to investigate the clinical impact of persistent hypoperfusion that was detected immediately after recana...

Adaptive feedforward construction method for precision motion stage based on iterative learning control

Feedforward compensation strategy is becoming increasingly important on improving control performance of the modern ultra-precision motion stages since the motion stages behave more flexible dynamic characteristics increasingly. Among numerous feedforward compensation strategies,...