Emory University

Maternal healthcare quality, continuity, and experiences among pregnant adolescents and adult women in Ethiopia, Kenya, and South Africa: A cohort study

The capacity of health systems to provide quality care for pregnant adolescents remains underexplored. This study examined the quality, continuity, and experiences of maternal healthcare among pregnant adolescents (<20 years) compared with adult women (20 + years) in Ethiopia, Ke...

Associating Mycobacterium tuberculosis genomic variants with minimum inhibitory concentrations to delamanid and pretomanid

Emerging resistance to delamanid (DLM) and pretomanid (Pa) threatens drug-resistant tuberculosis (DR-TB) treatment outcomes. The lack of rapid molecular diagnostics, due to limited knowledge of resistance-conferring mutations, along with standardization challenges for critical co...

Evaluating Creative Cognition as a Risk and Resilience Factor for Burnout in Pediatric Emergency Medicine

OBJECTIVES: Burnout is common among pediatric emergency medicine (PEM) physicians, but the relationship between creative problem-solving (CPS) preferences and burnout is not well understood. This study examined associations between CPS mindsets and burnout in PEM. METHODS: This c...

A final paradise: nursing homes and care for the elderly during the Great Leap Forward

Today, China faces a deepening demographic crisis with people aged 60 and over constituting over 20% of the population. This phenomenon, and the accompanying construction of old-age homes nationwide, raises important questions about the history of eldercare in modern China. In fa...

Systemic Retinoids in Cutaneous T-Cell Lymphoma: A Scoping Review of Clinical Use and Evidence Gaps

Systemic retinoids are ubiquitously used in cutaneous T-cell lymphoma (CTCL), often in combination with skin-directed or systemic therapies, yet their role within contemporary multimodal treatment strategies has not been comprehensively synthesized. We conducted a PRISMA-ScR-guid...

Specialists' Evidence Evaluation and Judgments in Audits

ABSTRACT Audits of complex fair value estimates involve evaluating and challenging key client assumptions. Auditors generally lack the necessary expertise to perform this work, and thus, they often engage valuation specialists to perform this audit work. However, valuation specia...

Cybersecurity as a precondition for the carbon–neutral grid: an investment framework for U.S. utility cybersecurity capital allocation

Abstract The transition to a carbon–neutral electricity system depends on the widespread integration of distributed and inverter-based renewable resources. The U.S. Department of Energy and the North American Electric Reliability Corporation have identified these resources as inc...

Developing a Dual-Targeting CD33/CD70 CAR T-Cell Strategy Against Acute Myeloid Leukemia to Overcome Tumor Heterogeneity

Background: Acute myeloid leukemia (AML) remains the deadliest form of leukemia in children and adults despite therapeutic advances in recent decades. Chimeric antigen receptor (CAR) T-cell therapy is one such therapeutic approach that has been explored preclinically and clinical...

How Does Physician Clinical Experience Affect Quality of Care, as Measured by Length of Stay?

Introduction Length of stay (LOS) is a widely utilized metric of hospital quality and operational efficiency. Prolonged LOS is associated with increased healthcare costs, greater risk of hospital-acquired complications and infections, and reduced bed turnover, negatively affectin...

Integrating genetically predicted transcriptomic signatures with longitudinal real-world data for drug repurposing in Alzheimer’s disease

Drug repurposing offers a potential strategy to expand treatment options for conditions with limited therapies, but advancing repurposing candidates toward clinical implementation remains a challenge. Large-scale data, together with advanced genetic and epidemiological methods, m...

Widespread Biosynthesis of Thiohistidine Dipeptides in Bacteria

Abstract Natural products have been paramount in inspiring novel chemistry as well as providing therapeutic agents and chemical tools for biological applications. A recently emerging class of natural products, the thio/seleno-imidazoles (TSIs), contains C–S or C–Se bonds that are...

A phase II pilot trial of an indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor (INCB024360) plus a multipeptide melanoma vaccine (MELITAC 12.1) in patients with advanced melanoma, with sequential evaluation of the tumor microenvironment

Indoleamine 2,3-dioxygenase-1 (IDO1) can mediate immune dysfunction by reducing tryptophan (Trp) and increasing kynurenine (Kyn). The CITN-04 clinical trial (NCT01961115) tested the safety and clinical activity of combination therapy with IDO1 inhibitor epacadostat (INCB024360) p...

Differential DNA methylation in blood as potential mediator of the association between ambient PM2.5 and cerebrospinal fluid biomarkers of Alzheimer's disease among a cognitively normal population-based cohort.

toxicity in the pre-clinical stages of AD.

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

22q11.2 Deletion Syndrome: A Comprehensive Review for Pediatricians From Diagnosis to Adult Care Transition

Affecting ~1 in 4000 to 6000 live births, 22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion syndrome. It results from a 1.5 to 3 Mb heterozygous deletion at chromosome 22q11.2 and is associated with a broad spectrum of clinical manifestations, inc...

Artificial Intelligence as the Computational Framework for Adaptive Closed-Loop Neuromodulation in Psychiatry

Adaptive neuromodulation offers a path toward personalized neuropsychiatric treatment by allowing therapy to respond to clinically meaningful neurophysiological and behavioral changes. Its clearest clinical precedents are responsive neurostimulation for epilepsy and adaptive deep...

Connectomic Determinants of Subcallosal Cingulate Deep Brain Stimulation for Depression

OBJECTIVE: Subcallosal cingulate (SCC) deep brain stimulation (DBS) has shown promise for treatment-resistant depression. This study retrospectively evaluated a large curated SCC-DBS dataset to identify connectomic factors associated with sustained clinical improvement across pat...

Integrity of Tumor Tissue Collected by Ultrasonic Aspirator: A Cellular and Molecular Perspective.

BACKGROUND AND OBJECTIVES: Preserving the quality and integrity of resected tumor tissue is essential to ensure the reliability of downstream analyses. The effects of ultrasonic aspirators (UAs) on cellular viability, tissue morphology, and molecular quality remain poorly charact...

Architecture-Guided Sequential Editing of Distinct Disulfides in Unprotected Peptides

Abstract Disulfide modification typically relies on global reduction, preventing the selective manipulation of individual disulfide bonds within complex peptides. Here, we show that aromatic, ethyl, and tert-butyl disulfides embedded in fully unprotected peptides exhibit distinct...

Enhanced screening and bacterial sexually-transmitted infection diagnoses after HIV pre-exposure prophylaxis initiation

BACKGROUND: Recipients of HIV pre-exposure prophylaxis (PrEP) experience higher rates of gonorrhea and chlamydia diagnoses than non-recipients. However, it is unclear if these observations reflect a causal relationship between PrEP initiation and acquisition of sexually transmitt...