Emory University

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Predictive functional network connectivity signature of infancy age and eye-region fixation behavior

Functional connectivity (FC) has been established as a fundamental property of brain organization, intricately linked to both neurodevelopmental processes and the emergence of social behavior. Prior research has demonstrated that individual variability in brain age is associated...

Fabry Disease: An Updated Perspective and Review of Treatment and Therapies

Fabry disease (FD) is a progressive, multisystemic, X-linked lysosomal storage disorder that when untreated leads to decreased quality of life, chronic pain, and end organ disease; however, advances in therapy have significantly altered its original natural history. This paper br...

Time-surrogate variables enhance the association between cardiotocographic features and intrapartum hypoxic-ischemic encephalopathy

Abstract Background Interruptions to the flow of oxygenated blood to the fetal brain during labor can lead to hypoxic-ischemic encephalopathy (HIE). Timely preventive interventions for suspected hypoxemia are crucial to avoid progression to neurological injury. Prior research has...

CoxFormer enables spatial omics inference with multimodal generative modeling

Gene co-expression maps transcriptome-wide gene-gene relationships, yet high-quality estimates cover less than half the genome. Meanwhile, spatial omics either profiles restricted in situ panels or lacks cellular resolution. Extending co-expression transcriptome-wide could overco...

Enteric pathogens in soil adjacent to public waste bins in Maputo, Mozambique offers potential for environmental surveillance

Abstract Wastewater surveillance has been widely adopted since the COVID-19 pandemic, but non-sewered or onsite sanitation is a common form of sanitation in cities of low- and middle-income countries. Environmental surveillance in these settings requires expanding analyses beyond...

A Hybrid Transfer Learning Approach for Ambient PM2.5 Exposure Modeling in LMIC Contexts: A Case Study from Lima, Peru

Abstract Exposure to fine particulate matter (PM2.5) contributes to millions of premature deaths annually worldwide. While epidemiological studies increasingly rely on geospatial technologies, such as satellite remote sensing, low-cost sensors, and chemical transport models, to q...

Tongue swab Xpert MTB/RIF Ultra for tuberculosis diagnosis in Ethiopian prisons

Tuberculosis (TB) diagnosis remains a major challenge in Ethiopian prisons, where access to diagnostics is limited. Current TB diagnostic strategies in Ethiopian prisons rely primarily on sputum-based testing. However, sputum collection is often challenging due to logistical barr...

Analysis of real‐world clinical outcomes of perioperative chemotherapy compared to preoperative chemoradiotherapy in esophagogastric adenocarcinoma

BACKGROUND: Nonmetastatic esophagogastric adenocarcinoma require multimodal treatment for management. However, real-world treatment patterns and outcomes in these patients are limited. We evaluated the survival outcomes associated with the common treatment combinations in the Nat...

The Role of Macrophages in the Immune Response to Peritoneal Infection with Dirofilaria immitis Larvae in the Mongolian Gerbil (Meriones unguiculatus)

The host cellular mechanisms determining whether Dirofilaria immitis (canine heartworm) larvae establish infection remain poorly understood. The Mongolian gerbil (Meriones unguiculatus), a naturally nonpermissive host, mounts a rapid macrophage-dominated peritoneal cellular respo...

Lipid-Rich Urothelial Carcinoma

Lipid-rich urothelial carcinoma (LR-UC) is a rare subtype, with ∼65 cases reported in the literature. Here, we report the largest case series of bladder LR-UC, including 40 patients. Clinical follow-up was available for 29 patients. Twenty-seven patients had at least 2-years foll...

Factors associated with completion and improvement following integrative oncology acupuncture in a racially diverse population

Acupuncture is an important integrative therapy in oncology settings as an adjunctive management option for cancer-related adverse effects. However, barriers to utilization of acupuncture in minority populations have been reported. This study sought to assess factors that impact...

Platelet Reactivity and Sex Differences: Clinical Implications for Women

Platelets are central to hemostasis and thrombosis. Excessive platelet activation contributes to arterial thrombotic events, including myocardial infarction, ischemic stroke, and complications of peripheral artery disease, whereas excessive platelet inhibition increases bleeding...

Commensal bacteria inhibit viral infections via a tryptophan metabolite

Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplored. Here, we define a pathway by which viral inf...

Seizure Action Plans Beyond the Neurology Clinic: What Emergency, School, and Primary Care Teams Need to Know for Children With Epilepsy

Most seizures in children with epilepsy occur outside the neurology clinic. Seizure action plans (SAPs) are designed to extend the neurologist's management plan into these settings. Early SAPs primarily targeted caregivers, while current plans target not only caregivers but also...

suPAR Identifies Treatment-Resistant Inflammatory Risk Beyond hs-CRP in Type 2 Diabetes With Coronary Artery Disease: An Ancillary Analysis of BARI 2D

OBJECTIVE To determine whether soluble urokinase plasminogen activator receptor (suPAR) is modified by randomized diabetes and revascularization strategies in patients with type 2 diabetes and coronary artery disease and whether combined suPAR and hs-CRP classification refines re...

Full Plate Living Evaluation and Case Series

Dietary interventions can improve cardiometabolic health, however, affordability, sustainability, and efficacy remain a challenge. Full Plate Living (FPL) is a free, virtual, research-based, experience-centered nutrition program that has been shown to improve health. Here, we des...

CONRep: Uncertainty-Aware Vision-Language Report Drafting Using Conformal Prediction

The objective of this study is to quantify uncertainty in vision-language model (VLM)-based automated radiology report drafting (ARRD) to support trustworthy clinical deployment. In this study, we developed CONRep in two settings: label-based and sentence-based. In the label-base...

Evidence of dengue transmission and a diverse Aedes mosquito virome on the Congo’s Angola border

Abstract Aedes mosquitoes are widely distributed across the Democratic Republic of Congo (DRC), and are major vectors of dengue (DENV), Zika, chikungunya (CHIKV), and yellow fever (YFV) viruses. While the high burden of malaria in the DRC receives considerable attention, arboviru...

Advocacy around abortion in a politically charged climate

PURPOSE OF REVIEW: To examine the evolving role of clinician advocacy in abortion care and to highlight key domains through which obstetrician-gynecologists can influence policy, clinical practice, and patient outcomes. RECENT FINDINGS: Increasing state-level abortion restriction...