Emory University

Integrating ctDNA-Based ESR1 m Monitoring Into First-Line Care for ER+, HER2– Advanced Breast Cancer: A Consensus Workflow

Circulating tumor DNA (ctDNA) is an emerging tool in precision oncology that enables noninvasive tumor profiling, detection of minimal residual disease, and treatment monitoring. Furthermore, routine ctDNA analyses offer the potential to support more personalized and dynamic canc...

Real‐Life Psychological Experiences and Cardiac Autonomic Physiology Among Survivors of a Myocardial Infarction in Midlife

Abstract Middle-aged women with ischemic heart disease have a higher burden of psychosocial factors compared with male counterparts. Data on daily life stress and autonomic physiology could help guide targeted interventions. We studied 302 individuals ≤ 61 years of age (129 women...

Increased baseline depression symptomology is associated with worse patient-reported pain and function following PRP for knee Osteoarthritis (OA): a retrospective longitudinal study

Abstract Objective Platelet-rich plasma (PRP) is increasingly used to treat knee osteoarthritis (KOA), but variability in reported outcomes has limited broader adoption. Patient-specific psychosocial factors, including depressive symptoms, may be associated with patient-reported...

Missed Opportunities: Toxicology Screening Remains Incomplete Among Firearm-Injured Adolescents

Background Firearm injury remains the leading cause of death among children and adolescents in the United States. Firearm-injured adolescents are at increased risk for substance use and behavioral disorders, yet toxicology testing remains inconsistent despite national recommendat...

Psychotherapy and Antidepressant Use After the US Preventive Services Task Force–Recommended Depression Screening

Importance Fewer than one-third of adults with depression receive any treatment for depression. It is important to evaluate the association between the 2016 US Preventive Services Task Force (USPSTF) recommendation and depression treatment nationally. Objective To examine changes...

Associations between methodological quality and representation in clinical trials of systemic lupus erythematosus therapies

Background Randomized clinical trials support drug development and uptake of new therapies for systemic lupus erythematosus (SLE). However, challenges to conducting high-quality clinical trials have been noted, including underrepresentation of minoritized populations. Currently,...

Gout May Mimic Infection, Even Years After Achilles Tendon Repair

BACKGROUND: Gout can affect tendons in addition to joints and may clinically resemble infection. The resulting diagnostic uncertainty may lead to surgical intervention or antibiotic treatment, even in patients whose symptoms might be managed medically if gout is recognized earlie...

Computation-through-Dynamics Toolkit: Simulated datasets and quality metrics for dynamical models of neural activity

A primary goal of systems neuroscience is to discover how ensembles of neurons transform inputs into goal-directed behavior, a process known as neural computation. A powerful framework for understanding neural computation uses neural dynamics – the rules that govern how neural ac...

Soft tissue sarcoma unmasked: An atypical presentation of primary cutaneous B-cell lymphoma

Introduction: Primary cutaneous follicle center lymphoma (PCFCL) is the most common subtype of primary cutaneous B-cell lymphoma and is typically an indolent malignancy with an excellent prognosis. However, atypical presentations may mimic soft tissue sarcoma or high-grade lympho...

Development and Validation of a Coronary Artery Calcium Volume and Density Score

BACKGROUND: Coronary artery calcium (CAC) scoring is a useful tool for coronary heart disease (CHD) risk prediction. The current standard method, the Agatston score, weights plaque area upward by density. However, higher density is inversely associated with CHD. We aimed to devel...

Care of the Sexual or Gender Minority Community Living with Cystic Fibrosis: A Survey of United States and Canadian Multidisciplinary Health Care Providers

PURPOSE: Lesbian, gay, bisexual, transgender, queer, intersex, asexual, or another sexual or gender minority (LGBTQIA+) people face health inequities and commonly report health care avoidance. We examined how multidisciplinary subspecialist providers care for LGBTQIA+ people with...

Development of a Screening Workflow for the Halogenation of Nitrogen Heterocycles with Vanadium-Dependent Haloperoxidases

Abstract The halogenation of nitrogen heterocycles is a privileged transformation for accessing important synthetic intermediates and biologically active targets in medicinal chemistry. Despite the importance of N-heterocycle halogenation, current methods rely on reagents or cata...

Zika virus produces two isoforms of the NS2A protein that play mutually exclusive roles in viral replication and virion assembly

Zika virus (ZIKV), dengue virus, and several other orthoflaviviruses cause disease outbreaks in human and animal populations worldwide. The orthoflaviviral nonstructural protein 2A (NS2A) is critical for both viral replication and virion assembly. However, due to its small size,...

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as...

Expression patterns of CD24 and CD27 resolve the origins and gradual differentiation of CD11c+ atypical memory B-cells after malaria infection

Abstract Atypical B-cells (ABCs) are observed across infections, yet their ontogeny and differentiation remain unclear. Using high-dimensional flow cytometry, single-cell transcriptomics, V(D)J sequencing, and functional assays in samples from individuals with malaria and healthy...

Tri-Encoder Disentanglement with Dynamic Preference Gating for Cross-Domain Recommendation

Modeling user intent across heterogeneous domains remains a central challenge in cross-domain sequential recommendation (CDSR). Although cross-domain sequences naturally embed richer behavioral cues that traverse multiple domains, existing approaches often struggle to disentangle...

Procedural Outcomes of Leadless Pacemaker Extraction and Retrieval: A Systematic Review and Meta‐Analysis With Descriptive Synthesis of Post‐Implant Management

ABSTRACT Introduction Leadless pacemakers reduce lead‐ and pocket‐related complications, but pooled evidence on the procedural outcomes of their extraction and retrieval remains limited. Methods and Results A systematic review and meta‐analysis (PROSPERO CRD420261397097) evaluate...

Association Between Interhospital Transfer, Readmission, and Inpatient Mortality Among Older Adults

ABSTRACT Background Interhospital transfer (IHT) is a key strategy for providing access to specialty care; however, it is associated with multiple adverse outcomes, including prolonged length of stay, increased risk of inpatient mortality, and reduced rates of discharge home, par...

Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers

Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...

The future management of HS : People with HS as partners

Abstract Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease with profound impact on quality of life. Increasing recognition of the patient's role as an active partner in their own care has transformed approaches to disease management, yet a conceptual framework...