Emory University

Autoimmune diseases involving the gastrointestinal tract: clinical patterns, imaging spectrum, and complications

Autoimmune diseases frequently involve the gastrointestinal (GI) tract and can present with nonspecific symptoms that delay diagnosis. Their manifestations range from subtle motility disturbances to life-threatening ischemia, perforation, or obstruction. Advances in cross-section...

Type II achalasia unmasked by EndoFLIP and high‐resolution manometry in a child with eosinophilic esophagitis

ABSTRACT Eosinophilic esophagitis (EoE) is a chronic immune‐mediated disease characterized by esophageal dysfunction and eosinophilic inflammation. Persistent dysphagia despite histologic remission should prompt evaluation for alternative etiologies. A 10‐year‐old male with asthm...

Neural competition between prefrontal and auditory cortex constrains novel sound strategy learning

In nature, animals learn to replace predisposed behaviors with new strategies, yet the neural constraints on these transitions are unclear. Using an ethological search task in mice, we reveal medial prefrontal cortical (mPFC) neural correlates of a predisposed win-stay strategy t...

Ribosomal protein bL27 protects translating ribosomes from tmRNA-SmpB

Bacterial ribosomal protein bL27 is universally conserved, and its amino terminus is adjacent to the peptidyl transfer center, yet its roles in translation remain unclear. Combining genetics, biochemistry, and molecular dynamics, we show that bL27 has an unexpected role in preven...

Leveraging Artificial Intelligence and Natural Language Processing in Legal Epidemiology Studies: Opportunities and Challenges

Legal epidemiology - the study of how laws influence health outcomes - is an emerging field with potential to inform policy and improve public health. Shortages of specialists who can commit the extensive time required for these analyses has hindered progress in this area. Featur...

Regional CO 2 and CH 4 inversion system using WRF-Chem (v4.4)/DART (v9.8.0) and continuous high-precision observations over the Korean Peninsula

Abstract. Quantifying greenhouse gas (GHG) emissions over complex terrain remains a significant challenge for conventional inversion systems due to the high sensitivity of tracer transport to surface heterogeneity. We develop a high-resolution dual-species GHG top-down inversion...

Multimodal radiopathological integration for prognosis of limited and extensive stage small cell lung cancer

Small-cell lung cancer (SCLC) is an aggressive malignancy with poor survival and no validated prognostic biomarkers. We developed and validated a multimodal artificial intelligence–based radiopathomic framework to predict progression-free survival (PFS) by integrating radiologic...

Unintentional Intra-Implant Fat Injection During Breast Fat Grafting

Background: Fat grafting is commonly used in implant-based breast reconstruction to improve contour and soft-tissue quality. Cannula-related implant injury during fat grafting is considered rare and is infrequently discussed in the literature. Methods: A focused review of PubMed...

Successful Lysogen Formation for Cluster AS2 Phage, Kuleana

<p>We present experimental data for lysogen formation by phage Kuleana, a subcluster AS2 phage isolated using <em>Arthrobacter globiformis B-2979. </em>The efficiency of lysogeny was 0.5 %.</p>

Phosphonium-based disinfectants are as effective as best-in-class quaternary ammonium compounds in the eradication of established biofilms in antibiotic-resistant bacteria

ABSTRACT Disinfectants play a crucial role in infection prevention and control, acting as our first line of defense against pathogenic bacteria. Despite biofilms being a major contributor to recalcitrant infections, the development of novel disinfectants often focuses on bacteria...

Development and validation of a theoretical test for ultrasound-guided biopsy competence in the head and neck

PURPOSE: This prospective study is designed to test the validity of a multiple-choice question (MCQ) test in assessing theoretical knowledge of ultrasound-guided fine-needle aspiration biosy and core-needle biopsy of the head and neck. METHODS: Seven international experts reached...

Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

BACKGROUND: Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST...

Encapsulation and Controlled Release of Human Spinal Cord Organoid‐Derived Extracellular Vesicles for Tissue Patterning in Viscoelastic Hyaluronic Acid Hydrogels

ABSTRACT Human induced pluripotent stem cells (hiPSCs) can differentiate into various types of central nervous system organoids which are valuable for applications in tissue engineering and injury repair. The secreted extracellular vesicles (EVs) of organoids, in particular the s...

Primer on Video-oculography and Video Head Impulse Testing for Neurologists

Abstract Purpose of Review Eye Movement and Vestibular findings can be manifestations of a wide range of neurologic diseases including and beyond those associated with peripheral vestibular dysfunction. Video-oculography (VOG) and video head impulse testing (vHIT) are accessible,...

Concessions and Protest Demobilization

How and why do concessions, or promises to implement reform in the future, affect protest mobilization in autocracies? Concessions are a routine response to protest and generate a puzzling empirical regularity: Although autocrats often renege once protest abates, concessions can...

Probiotic-Associated Invasive Infection Among Preterm Infants

This cohort study examines the incidence of invasive bacterial infection associated with probiotic supplementation among preterm infants.