Emory University

Originally delivered as the 2021 H. Paul Douglass Lecture: The Meaning of American Progress: Race, Science, and Redemption Religious Research Association

As the United States ponders 250 years of nationhood, I have returned to my 2021 H. Paul Douglass Lecture, delivered at the Religious Research Association’s Annual Meeting, to help contextualize where the nation stands today. As I argued then, America’s citizenry, researchers, an...

Prediction of cardiovascular outcomes using electrocardiography from overnight polysomnography.

STUDY OBJECTIVES: Polysomnography (PSG) is the gold standard for diagnosing sleep disorders, which are recognized as cardiovascular risk factors. Single-lead electrocardiograms (ECGs) are recorded during PSG but rarely analyzed, presenting an opportunity to leverage overnight ECG...

Clarifying the Concept of “Unanticipated Transfer to the ICU”: A Scoping Review

Unanticipated transfer to the intensive care unit (ICU), typically defined as an unscheduled escalation of care from inpatient general wards, is widely used in clinical research as a marker of adverse events, clinical deterioration, and system failure. However, its conceptual mea...

Sex-dependent DNA methylation in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) shows well-established sex differences in incidence, age at onset and progression, but their biological basis is unclear. We hypothesised that the DNA methylation changes associated with ALS differ between the sexes, which would point to sex-sp...

Feasibility of Collaborative Assessment and Management of Suicidality–Brief Intervention in an Emergency Department With Youth Who Are Suicidal

BACKGROUND: Emergency departments (EDs) are key entry points for many youth experiencing suicidal thoughts and behaviors into mental health care. ED clinicians play a critical role in crisis intervention, prevention, and linking patients to ongoing care, yet many report uncertain...

Comparison of prenatal self-report of tobacco use to direct measurement of umbilical cord cotinine

Abstract Objective This study compared maternal self-reports of prenatal tobacco product use with biochemically confirmed cotinine in umbilical cord tissue in newborns exposed to opioids in utero and unexposed controls. Study design Secondary data analysis on 179 pregnant women a...

Thy1-Neuron p38α knockdown protects against neurological consequences following repetitive mild traumatic brain injury

Mild traumatic brain injuries (mTBI) can substantially impact quality of life, and repetitive mTBIs (rmTBIs) can amplify injury effects compared to a single injury. However, effective clinical treatments remain elusive, largely due to an incomplete understanding of the underlying...

Determinants of Delivery Hospital Choice in Georgia, 2016–2021

Background: US maternal mortality and severe maternal morbidity (SMM) are marked by substantial disparities by race, payer, and geography. To the extent that such disparities are driven by differences across hospitals rather than within hospitals, understanding what shapes delive...

Changes in arbovirus risks and responses from 2020 to 2026

Abstract Since 2020, viruses spread by mosquitoes and biting midges have become a larger and less predictable public health challenge. Dengue continues to cause the greatest burden, but chikungunya, Oropouche, and other viruses are re-emerging or spreading into new areas. In this...

Diversity drives disease by Candida auris

The resilience of the emerging fungal pathogen Candida auris poses a significant challenge to public health. In a recent study examining how this pathogen navigates changing host environments, Tedja et al. show that sensing nutrient availability differences between body sites is...

Potent Antivirals for Respiratory Syncytial Virus Detected via Peptide-Based Fusion Inhibitor Screening

Abstract The respiratory syncytial virus (RSV) causes fatal pneumonia in neonates, infants, and older adults. However, no approved antiviral drugs exist for RSV; furthermore, the currently available antibody-based therapies are expensive and do not provide complete protection aga...

Reprogramming the tumor immune landscape through SPP1 targeting

Abstract Beyond its canonical roles in bone mineralization and extracellular matrix remodeling, secreted phosphoprotein 1 (SPP1) has emerged as a central regulator of the tumor microenvironment (TME), orchestrating immunosuppressive programs that drive immune evasion and tumor pr...

Monospecific antibodies reveal reduction of granulins in frontotemporal dementia caused by GRN mutations

Loss-of-function mutations in the progranulin (PGRN) gene ( GRN ) are a major cause of Frontotemporal dementia (FTD), also known as frontotemporal lobar degeneration (FTLD). PGRN is a lysosomal protein implicated in neuroprotection, proteostasis, and regulation of lipids includin...

Perceived changes in mothers’ outcomes following a pilot parenting program for couples with young children in Mwanza, Tanzania: A longitudinal qualitative study

There is growing interest in engaging not only mothers but also fathers in parenting programs to improve nurturing care, psychosocial support, and early childhood development. However, few studies have explored how mothers perceive and benefit from participating in parenting inte...

Capturing the Patient Voice: Qualitative Assessment of Daridorexant’s Impact on Patients with Insomnia and Comorbid Nocturia from a Randomized, Placebo-Controlled Crossover Trial

Chronic insomnia frequently co-exists with nocturia, contributing to impaired sleep quality and reduced health-related quality of life. A recent randomized cross‑over study found that daridorexant improved sleep duration, insomnia severity, daytime functioning, and nocturnal void...

Physician- and Practice-Level Variation in Clinical Trial Participation Among Patients With Advanced Cancer

Importance Clinical trial enrollment is essential to advancing cancer care, yet participation among patients with advanced cancer remains low. While patient-level barriers are frequently cited, the role of health care delivery factors—specifically physician- and practice-level va...

Redefining leptomeningeal metastasis in non–small cell lung cancer: From terminal complication to molecularly managed disease

Leptomeningeal disease (LMD) is one of the most devastating complications of advanced non-small cell lung cancer (NSCLC), historically associated with profound neurologic morbidity and poor survival. Advances in cerebrospinal fluid (CSF)-based diagnostics, improved molecular char...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Court-Documented Adverse Financial Events Before Cancer Diagnosis and Mortality Risk

This cohort study investigates the association between prediagnostic adverse financial events among individuals newly diagnosed with cancer and mortality risk.

Implementation and continuation in a network CURE: insights from the Bean Beetle Microbiome Project

The positive impact of course-based undergraduate research experiences (CUREs) on student outcomes is widely acknowledged. Yet, barriers to initial and then continued implementation of CUREs limit their use. In this Perspective, we expand on previous research on why faculty do (o...