Emory University

Mole or Early Melanoma? Rethinking Early Detection, Overdiagnosis, and the Benign–Malignant Paradigm

Melanoma early detection has been widely promoted on the assumption that diagnosing early tumors improves outcomes, but epidemiologic data increasingly challenge this assumption. In fair-skinned populations subjected to intensified surveillance, diagnoses of thin invasive and in...

Emulating the influence of exoskeleton stiffness on primary afferent feedback in rat isolated muscle-tendon unit

Abstract Exoskeletons assist and augment movement, but their effects on proprioceptive feedback remain poorly understood due to challenges in making direct measures of sensory signals in humans. Here, we leveraged a benchtop animal model to begin to explore how mechanical context...

Changing role of tenure in academic medicine: a national survey of faculty affairs deans

Background Tenure has traditionally signified academic freedom, job security and scholarly independence at US medical schools, yet the proportion of faculty in tenure-track positions has declined markedly in recent decades. Methods To assess tenure’s contemporary relevance, parti...

Prospective metagenomic sequencing of wastewater across the United States yields robust viral enrichment and concordance with digital PCR measurements

Metagenomic sequencing is increasingly applied to wastewater to characterize the diversity, dynamics, and relative abundance of human and animal viruses. Among these sequencing approaches are those that enrich viral nucleic acids from the wastewater matrix, aiming to increase the...

Clinical Practice Guideline for the Diagnosis and Treatment of Urinary Tract Infection in Children From 8 Days to 5 Years of Age

Urinary tract infection (UTI) is one of the most common bacterial infections in infants and young children, with a prevalence of 7% in infants with fever. This clinical practice guideline (CPG) provides an update of the literature and clinical recommendations of the 2011 American...

Targeted Gastrointestinal Delivery of mRNA Lipid Nanoparticles Enables Systemic Vaccination and Glucagon-like Peptide-1 Metabolic Therapy

Abstract Lipid nanoparticles (LNPs) administered parenterally often show poor localization to multiple tissue types, including the pancreas and gastrointestinal (GI) tract. Furthermore, patients typically prefer orally administered drugs to those that are given parenterally. We t...

Convergent Total Synthesis of (−)-Methyl Gummiferolate Enabled by Pattern Recognition and Radical Cyclization

Abstract We report herein an enantioselective total synthesis of (−)-methyl gummiferolate, a complex diterpene natural product with a tetracyclic ent-atisane core including a bicyclo[2.2.2]octane subunit and three all-carbon quaternary centers. Gummiferolic acid has demonstrated...

Detection of Chagas Disease from the ECG: The George B. Moody PhysioNet Challenge 2025

Abstract Objective: Chagas disease is a parasitic infection that is endemic to Latin America and primarily transmitted by insects. When untreated, Chagas disease can cause cardiomyopathy. Serological testing capacities for Chagas disease are limited, but Chagas cardiomyopathy oft...

Proteolytic Activation of T Cell Engagers And Bispecific Proteins Using Modular Coiled-Coil Peptides

Abstract Bispecific T cell engagers (BiTEs) are engineered immunotherapeutic molecules designed to direct the body’s immune system against malignant cells by physically connecting T cells to target cells, triggering cytotoxic responses. BiTEs have typically engaged T cells via αC...

Administration of a phosphodiesterase 4B inhibitor reduces hippocampal neuronal cell death after global cerebral ischemia

Abstract Global cerebral ischemia (GCI) causes widespread neuronal injury, with hippocampal neurons being particularly vulnerable. This study examined whether post-GCI treatment with amlexanox (AMX), a phosphodiesterase 4B (PDE4B) inhibitor, reduces hippocampal neurodegeneration...

Top Ten Tips Palliative Care Clinicians Should Know About Collaborating with Consultation-Liaison Psychiatry

Palliative care (PC) and consultation-liaison (CL) psychiatry are complementary clinical disciplines that frequently care for the same patients facing serious illness complicated by psychiatric symptoms, psychological distress, neuropsychiatric syndromes, and high-stakes medical...

Hybrid/collision ameloblastoma-ameloblastic fibroma: a case with molecular features supporting a tumor-in-tumor model

Hybrid/collision odontogenic tumors are a rare and controversial phenomenon not formally recognized as a distinct category in the WHO Classification of Head and Neck Tumors and their diagnosis relies mainly on histomorphology. This report presents a unique mandibular odontogenic...

Review Article of Platelet-Rich Plasma and Facet-Mediated Mechanical Low Back Pain

Introduction and Aim: Facet-mediated mechanical low back pain is a common contributor to chronic disability worldwide. While platelet-rich plasma (PRP) has demonstrated efficacy in discogenic low back pain, its role in facet joint-mediated pain remains less clearly defined. This...

Primary healthcare system readiness for the prevention and management of non-communicable diseases in Nepal

In 2016, Nepal adopted the World Health Organization’s Package of Essential Non-Communicable Disease Interventions (PEN) to address the rising burden of non-communicable diseases (NCDs). This study evaluated the primary healthcare system’s readiness to prevent and manage major NC...

CCR5 blockade inhibits menstrual-driven proinflammatory T cell infiltration into the cervicovaginal mucosa of women

The menstrual cycle influences the development and severity of inflammatory disorders and susceptibility to infections, yet its direct role in shaping mucosal immunity remains poorly defined. Here, we tracked CD4 T cell surveillance in the female reproductive tract (FRT) of cycli...

Community priorities for programs using HIV molecular epidemiology: A best-worst scaling

Background: HIV molecular epidemiology (HIV-ME) uses genetic sequencing to study viral evolution, detect transmission clusters, and guide public health responses. Ethical, legal, and social implications of HIV-ME have been raised, yet quantitative evidence on community perspectiv...

Variations in diagnosis and management of hemodynamically significant patent ductus arteriosus across neonatal intensive care units in the Children’s Hospitals Neonatal Consortium

Abstract Objective Collate patent ductus arteriosus (PDA) guidelines among Children’s Hospitals Neonatal Consortium (CHNC) centers and identify variations in the diagnosis and management of hemodynamically significant PDA (hsPDA). Study Design: A descriptive survey requesting wri...

Bankruptcy lawyers and credit recovery

I study how bankruptcy law firm advertisements affect household credit, exploiting the borders of local TV advertisement media markets. I document a significant advertising effect on filing rates and subsequently show that ad exposure is associated with better financial outcomes....

Clustering Hybrid Functional and Vector Data

ABSTRACT Modern biomedical studies increasingly collect hybrid data, consisting of functional observations (e.g., curves or images) and multiple scalar (vector‐valued) clinical variables. Integrating these modalities in an unsupervised learning framework can improve patient subgr...

A newborn with glycogen storage disease type Ib presenting with hypoglycemia and evidence of mitochondrial dysfunction

Glycogen storage disease type Ib (GSDIb) is an inherited disorder of carbohydrate metabolism that commonly presents in infancy. Here, we describe a case of GSDIb who presented on the first day of life with severe hypoglycemia and lactic acidosis, prompting a broad differential di...