Cornell University

Immunization with mRNA-LNP Elicits De Novo IgG Responses in the Presence of Maternal Antibody

Background/Objectives: Maternal antibodies can inhibit vaccine-specific humoral responses in early life, leaving infants at increased risk for severe disease for vaccine-preventable infections. In the case of SARS-CoV-2, infants under the age of 3 months represented most child ho...

Evaluating Minority Representation in the All of Us Research Program: Progress and Ongoing Challenges.

Persistent underrepresentation of Asian and Hispanic participants highlights ongoing gaps as AoU recruitment continues. Continued efforts toward equitable participation will be important for achieving the scientific and ethical goals of precision medicine.

Disorder‐Broadened Topological Hall Phase and Anomalous Hall Scaling in FeGe

ABSTRACT Magnetic skyrmions are promising candidates for next‐generation spintronic memory and logic due to their nanoscale size and topological stability. However, skyrmion‐based devices remain limited by narrow operating temperature windows that typically exclude cryogenic regi...

What one sees depends on how far the eye has moved

Humans explore visual scenes through frequent, rapid gaze shifts known as saccades. These movements redirect the high-acuity region of the retina toward objects of interest, thus selecting information based on location. Here, we show that saccade amplitude provides a separate and...

Shared CI-linked bioenergetic dysfunction and muscle-specific lipid/redox stress in skeletal muscle of male cardiometabolic HFpEF mice

Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF), particularly in its cardiometabolic form, where obesity, metabolic dysfunction, and impaired peripheral oxygen utilization contribute to functional limitation. Skeletal muscle mitochondr...

Headache Attributed to Genetic Vasculopathies

PURPOSE OF REVIEW: Headaches are a common chief complaint and a significant contributor to growing healthcare costs. Headaches are broadly categorized as primary or secondary, the latter indicating that they are a symptom of an underlying medical condition. Genetic vasculopathies...

FAIR-SHEPHERD: Fairness beyond Statistical Parity toward Structural Alignment

All fairness algorithms unavoidably rely on normative assumptions about fair treatment, yet these assumptions often remain implicit. We argue that these assumptions should be formalized as explicit, auditable policies and introduce FAIR-SHEPHERD , a structural policy-based framew...

Human Being, Robot Body: Hybrid Identity Expression in Teleoperated Robots

Historically telepresence research has focused on how interacting through a robot changes feelings of presence, or being ”there” in a remote place. Telepresence robots are designed and used to improve human-human interactions and relationships, so it is important to consider how...

Wind‐Driven Circulation Feedbacks Offset Tropical Geoengineered Sea Salt Emissions

Abstract Using a NOAA Geophysical Fluid Dynamics Laboratory coupled atmosphere–ocean (CM4) comprehensive model, we employ simulations of enhanced, geoengineered sea salt aerosol (SSA) emissions in the tropics to examine the circulation response to idealized marine cloud brighteni...

The Global Epidemiology of Metabolic Dysfunction-Associated Steatotic Liver Disease: Regional Hotspots, Trends, and Future Projections

Purpose of Review This review highlights the global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), assesses comparability of the former definition of non-alcoholic fatty liver disease (NAFLD)-era estimates with the 2023 steatotic liver disease (SL...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Unlocking soil nitrous oxide sink through labile carbon

Nitrous oxide (N 2 O), a potent greenhouse gas and the dominant ozone-depleting substance, is primarily emitted from soils. Understanding atmosphere-to-soil N 2 O uptake is crucial for harnessing the soil’s natural sink potential, yet its quantification and mechanistic drivers re...

Modernizing the Institutional Review Board Process for Implementation Science – A Narrative Review of Barriers and Ethical Considerations

Abstract Purpose of Review This review highlights the barriers and facilitators that implementation science studies face in the institutional review board (IRB) approval pathway and provides recommendations on how to potentially streamline this process. Recent findings Significan...

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

Aberrant activation of Wnt signaling results in unregulated accumulation of cytosolic β-catenin, which subsequently enters the nucleus and promotes transcription of genes that contribute to cellular proliferation and malignancy. Here, we sought to eliminate pathogenic β-catenin f...

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

ABSTRACT Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to correct these imbalances and achieve remission. However, most patients...

A Multilevel Intervention to Identify Individuals for Genetic Testing and Treatment

Importance Cascade genetic testing (CGT) is a key strategy for cancer prevention in families with hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome (LS), yet uptake among at-risk relatives remains persistently low, particularly in medically underserved popul...

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Baseline IPSS-M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo-HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of re...

Immune checkpoint molecules as biomarkers of Staphylococcus aureus bone infection and clinical outcome

Abstract Background Staphylococcus aureus prosthetic joint infections (PJIs) are broadly considered incurable, and clinical diagnostics that guide conservative vs. aggressive surgical treatments don’t exist. Understanding the human T cell response to chronic S. aureus osteomyelit...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

Pricing with Algorithms

This paper studies Markov perfect equilibria in a repeated duopoly model where sellers choose algorithms. An algorithm is a mapping from the competitor's price to own price. Once set, the algorithms respond quickly. Customers arrive randomly and sellers can periodically revise th...