Cornell University

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...

MRI Tract‐Based Quantitative Susceptibility Mapping of Limbic White Matter Alterations in Preeclampsia

BACKGROUND: Preeclampsia is associated with long-term cerebrovascular and cognitive risk, but tract-level white matter (WM) involvement remains incompletely characterized. PURPOSE: To investigate whether preeclampsia is associated with tract-level WM susceptibility alterations on...

A Route toPure Optical Rotation in Self-AssembledMaterials through Energetic Nondegeneracy

Abstract Achieving large optical rotation while preserving linear polarization and minimizing loss─“pure” optical rotation─remains a central challenge in chiral photonics. Solution-processed self-assembled materials can exhibit exceptional chiroptical responses (g-factor >...

ALD with AlternativeCoreactants: Which Work, WhichDo Not, and Why

Abstract In this work, we present a combined experimental and theoretical study that systematically evaluates a series of alcohols (i.e., primary, secondary, and tertiary) as coreactants for trimethylaluminum (TMA)-based atomic layer deposition (ALD) of Al2O3. We employed in situ...

Identification of SKI-II as a host-protective immunomodulator against Staphylococcus aureus infection

ABSTRACT Antibiotic resistance threatens the effectiveness of conventional antimicrobial agents, underscoring the need for host-directed therapies that enhance immune defense. Here, we present a cross-species discovery pipeline that couples a Caenorhabditis elegans–Staphylococcus...

Targeting Oncogenic KRAS Using Peptide Nucleic Acid Oligomers Attached to Cell-Penetrating Peptides

Approximately 30% of tumors contain an activating mutation in the oncogene KRAS, leading to increased cell proliferation that often promotes non-small cell lung cancers, colorectal adenocarcinomas, pancreatic ductal adenocarcinomas (PDAC), and other cancers. Among the most common...

Illegal markets for cigarettes and e-cigarettes

This paper discusses the long-standing illegal markets for cigarettes and the more recently emerged illegal markets for e-cigarettes. We identify three distinctive market fundamentals that help explain many features of the illegal markets. First, in contrast to some illegal goods...

Cytogenetic constraints on hybridization: A meta-analysis investigating the role of chromosome number in monocot hybrid evolution using a newly developed tool, the ploidy deviation index (PDI)

BACKGROUND AND AIMS: Hybridization is a major driver of plant diversity, yet the role of cytogenetic compatibility, particularly differences in chromosome number, remains poorly understood. Differences in parental chromosome number can present barriers to hybrid formation by disr...

Does TikTok promote or cannibalize music streaming? Estimands and identification with heavy-tailed outcomes

Abstract We study how TikTok affects demand for music on paid streaming platforms in the context of Universal Music Group’s (UMG) global withdrawal of its catalog from TikTok. Recent studies using this quasi-natural experiment have reached different conclusions about whether TikT...

Constraint-Based DEM Enhancement Using LiDAR Data at Sparse Highway-Bridge Locations

Abstract Digital elevation models (DEMs) are essential for infrastructure design and flood modeling, yet publicly available DEMs typically exhibit vertical accuracies of one to three meters, insufficient for these applications. This study develops and systematically evaluates a c...

Antibody kinetics against tetanus toxoid before and after primary vaccination of foals

Abstract Background Vaccination recommendations for foals against Clostridium tetani vary. Available studies assessing foal immune responses, maternal antibody interference, or individual variation often used small foal numbers. Objectives To quantify antibody responses after tet...

Macrophages tune NK cell IFNγ production through direct lipid transfer

Abstract Natural killer (NK) cells are critical effectors of innate immunity, but their activity is strongly influenced by metabolic state. While intrinsic NK metabolism has been studied extensively, less is known about how surrounding immune cells shape NK cell function. Here, w...

Theory and theoretical framework use for engineering education research: A systematic review of undergraduate disability research in the United States

Abstract Background Use of theory is a quality marker in engineering education research. However, it can be challenging to select an appropriate theoretical framework and explicate how that framework was used. Purpose Using undergraduate STEM disability research as an example, th...

Discovery of a peripheral Myh11-expressing nucleus pulposus cell population demontrating therapeutic potential for disc degeneration

Continual turnover of nucleus pulposus (NP) cellularity is critical for maintaining intervertebral disc (IVD) homeostasis; however, the presence and identity of potential progenitor cells within the NP remain unclear. This study identifies NP cells expressing myosin heavy chain 1...

Lipidomic and transcriptomic remodeling underlies early retinal pathogenesis in dry age-related macular degeneration

Abstract Dry age-related macular degeneration (AMD) is initiated by retinal pigment epithelium (RPE) dysfunction, yet early metabolic mechanisms linking RPE injury to photoreceptor dysfunction remain unclear. Using a physiologically relevant mouse model, we performed cell-type–re...

Intraprocedural cardiac computed tomography-fluoroscopy image fusion guided structural heart intervention: a proof of concept experience during transcatheter aortic valve implantation

Intraoperative image guidance using cardiac CT with fluoroscopy image fusion has been shown to facilitate structural heart interventions. However, there has been limited experience on CT image fusion with fluoroscopy using aortic root calcifications from intraoperative 3D cone-be...

Closing the Health Policy Implementation Gap With Artificial Intelligence

Importance: Health care policies often fail to achieve their goals due to implementation challenges attributable to workforce constraints, fragmented health information systems, and administrative complexity. This Special Communication proposes a framework for how artificial inte...

Is Postinflammatory Hyperpigmentation Truly “Post” in People With Darker Skin Tones?

This Viewpoint reviews how inflammation can coexist with hyperpigmentation, explains why inflammatory activity may be underrecognized in people with darker skin tones, and proposes an approach in which hyperpigmentation prompts continued assessment for persistent inflammation.

Population genomics reveals ginseng domestication and ginsenoside biosynthesis

Ginseng ( Panax ginseng ), a valuable medicinal plant, is cultivated for the bioactive ginsenosides with cardiovascular protective effects that are abundant in its roots. However, the genetic basis of its domestication and ginsenoside variation is not fully understood. In this st...

The Zooplankton International Geospatial dataset: A global repository of spatiotemporal freshwater zooplankton community composition data from lakes and reservoirs to support ecological research

Abstract Zooplankton transfer substantial energy in aquatic food webs and are used as indicators of environmental change. Syntheses of zooplankton community dynamics globally require datasets that span a wide range of environmental gradients; however, these datasets are limited d...