Cornell University

Lysine iminylation derived from ω-3 polyunsaturated fatty acids

Protein posttranslational modifications (PTMs) play a central role for regulating protein function and cellular processes, with many PTMs arising from reactions with electrophilic metabolites. Here we extend the known landscape of PTMs with the identification of “lysine C 3 -imin...

Preoperative Visual Field Patterns Associated with Selection for Concurrent Eyelid and Brow Ptosis Repair

Introduction: Determining when to perform combined eyelid and brow surgery for functional deficits remains subjective, despite measurable visual field (VF) impairment in affected patients. Objectives: We sought to identify VF patterns associated with selection for combined eyelid...

Modular Platform for Directing-Group-Free Radical Dicarbofunctionalization of Unactivated Alkenes via Dual Nickel/Energy-Transfer Catalysis

Abstract Multicomponent cross-coupling reactions of alkenes offer a powerful strategy for constructing three-dimensional, sp3 -rich molecular architectures, a key objective in modern medicinal chemistry. However, the regioselective dicarbofunctionalization of unactivated alkenes...

Implementing liquid biopsy in HR+/HER2− metastatic breast cancer: challenges and opportunities

PURPOSE OF REVIEW: Liquid biopsy (LB) is rapidly transforming the management of hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer (mBC). In this review, we discuss the most recent findings on circulating tumor DNA (ctDNA) and circulating tumor cells (CT...

Threatened Identity: Self Psychology Informed Communication for Serious Illness Care

Serious illness threatens both the body and the self: the coherent, continuous sense of who one is, from bodily integrity to psychosocial identity. When illness disrupts identity and patients confront mortality and dependence, a range of responses may follow, including behaviors...

Antiviral innate immunity in myocarditis: mechanisms and emerging therapeutics

Abstract Antiviral innate immunity is a decisive determinant of whether cardiotropic viral infection resolves or progresses to myocarditis and deadly heart failure. Viral myocarditis (VM) remains a leading cause of sudden death in children and young adults, yet its human pathophy...

Invisible Threats, Relentless Hunters: Biosurveillance of Airborne Plant Pathogens

Airborne dispersal enables plant pathogens to travel across fields, regions, and continents, fueling rapid epidemics and emerging disease threats. Biosurveillance, the systematic monitoring of airborne inoculum, offers the opportunity to detect pathogens before symptoms appear an...

Strategies To Sustain the U.S. Pediatric Anesthesiology Workforce

Pediatric anesthesiology is a deeply rewarding specialty, and the job market remains favorable for the trainees who choose it. However, the U.S. pediatric anesthesiology workforce is facing a convergence of challenges, including declining fellowship recruitment, increasing nonope...

Cell recovery and DNA extraction methods skew relative abundance estimations of foodborne pathogens and spoilage organisms on stainless steel surfaces

ABSTRACT Amplicon sequencing investigations of surface microbiota in food facilities often report the relative abundance of bacteria and fungi. However, physiological differences among cell types can result in variable cell recovery and DNA yields, thereby skewing relative abunda...

Intranodal Embolization of Lymphocele Following Anterior Lumbar Interbody Fusion: Case Report

Postsurgical lymphocele is a rare complication following anterior lumbar interbody fusion (ALIF), for which ideal management remains controversial. Our study presents a case of a 70-year-old woman who underwent a multilevel anterior and posterior fusion from L3 to the pelvis with...

PIP2 binding at allosteric site blocks activation in human rod CNG channels

Phosphatidylinositol-4,5-bisphosphate (PIP2) is a ubiquitous signaling lipid that regulates multiple ion channels. In human cyclic nucleotide-gated (CNG) channels, including the rod photoreceptor channel, PIP2 has been reported to exert inhibitory effects, but the underlying mech...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

A qualitative evaluation of clinicians’ experiences in diagnosis and management of women with gestational diabetes mellitus (GDM) in Pune, India

The prevalence of gestational diabetes mellitus (GDM) continues to rise in India, and globally. However, uncertainty remains regarding its diagnosis and optimal management. We explored how clinicians in India navigate GDM-related care to identify where additional guidelines or tr...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Truncated ErbB2 receptor expression lowers nucleus stiffness and increases migration of breast cancer cells

The mechanisms underlying mechanical differences among cancer cell lines with varying metastatic potential remain poorly understood, despite their clear therapeutic relevance. While comparisons between malignant and benign cell mechanics reveal systematic differences, these are d...

Increased maximum carbon release offsets half of the growth trend in annual land carbon sink

The terrestrial carbon sink has strengthened in recent decades through enhanced maximum CO2 uptake (MCU) and a longer carbon uptake period (CUP), whereas maximum CO2 release (MCR) remains less quantified. Using atmospheric inversion estimates and 16 terrestrial biosphere models,...

Information Geometric Regularization of the Barotropic Euler Equation

Abstract. Shock waves in gas dynamics feature jump discontinuities that hinder numerical simulations. Viscous regularizations are prone to excessive dissipation of fine-scale structures. In this work, we propose the first inviscid regularization of the multidimensional Euler equa...

Traces of Criminal Records: Digital Reputation and Information Concealment Policy

ABSTRACT In the United States, a robust data ecosystem aggregates and shares public records about people that may ultimately appear in Internet search results for a person's name. These records can include stigmatizing information and operate outside public policy efforts to conc...

Unconventional Materials for Light Dark Matter Detection

We propose the use of several unconventional materials as detectors for dark matter with mass beneath the MeV scale. These include the transition-metal dichalcogenide TiSe 2 hosting a low-energy plasmon in the charge-density-wave phase, Sr 2 RuO 4 containing a low-energy acoustic...

Wet-Spun Supramolecular Lignin/Alginate Fibers from Agricultural Residues

Abstract Purpose This is the 1st study to explore the development of fully biobased lignin/alginate fibers using lignin extracted from corn stover via the CELF process. It examines how lignin molecular weight and concentration affect fiber properties for sustainable material appl...