Cornell University

A Trilogy Theory of Moral Cowardice

Cowardice is a lack of courage to face danger. Moral cowardice occurs when the taking of a principled stand is avoided because of its risks, especially the disapproval or hostility of others. Moral cowardice is the result of a set of processes that begins with the recognition of...

Electroanalytical and Computational Investigation of Oxoammonium-Mediated Hydride Transfer

Abstract Oxoammonium-mediated hydride transfer is an important yet relatively underexplored elementary step in C–H functionalization. In this work, we employed cyclic voltammetry (CV) to measure the rates of hydride transfer between electrochemically generated oxoammonium catalys...

Pediatric Mental Health Integration and Perceived Quality of Care

OBJECTIVE: This study examined how access to behavioral and mental health (B/MH) professionals varied across general and subspecialty pediatricians and whether access to, and degree of, B/MH integration in clinical settings was associated with pediatricians' perceptions of health...

IncobotulinumtoxinA for Upper Limb Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled Trial

This double-blind, placebo-controlled, phase II trial (NCT04766723) investigated the efficacy and safety of incobotulinumtoxinA (Xeomin®) in the treatment of essential tremor (ET) of the upper limb (UL). Adults with ET of the UL were randomized 2:1 (n = 78) and treated (n = 77) w...

Cervical Disc Arthroplasty: Evolution, Evidence, and Future Directions in Motion-Preservation Surgery

➢ Cervical disc arthroplasty (CDA) provides clinical outcomes comparable with those of anterior cervical discectomy and fusion (ACDF) for 1-level and 2-level cervical degenerative disc disease (DDD), with durable long-term motion preservation. ➢ Although CDA is associated with lo...

A Complex‐Frequency Framework for Kerker Unidirectionality in Photonic Resonators

ABSTRACT Electromagnetic scattering exhibits various anomalous behaviors, such as forward or backward scattering effects known as the Kerker conditions. These anomalies appear in non‐Hermitian photonic resonators and are mathematically described by operators with complex eigenfre...

TIP-INN: A thermodynamics-informed machine learning framework for the mechanical behavior of rocks

Abstract Modeling the mechanical deformation of geological materials across relevant thermodynamic conditions and dynamic processes remains a fundamental challenge in Earth sciences. Conventional rheological models rely on isolated disciplinary approaches and hard-coded iterative...

Synthetic DNA Tracers Enable Ultra-High-Reproducibility Characterization of Aquifer Hydraulic Conductivity and Contaminant Transport

Abstract Reliable characterization of aquifer hydraulic conductivity (K) via tracer-based methods remains a major challenge due to environmental background noise. We report that synthetic DNA tracers, free of background-noise interference, enable highly reproducible tomographic i...

Effects of microwave or infrared radiation on protein ruminal degradation and in vitro intestinal digestibility in feedstuffs

Microbial crude protein ( MCP ) is the main source of amino acids ( AA ) in the small intestine, followed by rumen undegraded protein ( RUP ). Due to limited MCP synthesis and increased AA demand in high-producing ruminants, strategies to enhance intestinal protein availability a...

Protocol for quantifying chromatin DNA replication by multiplex labeling and single-molecule localization microscopy

We present a protocol for imaging and quantifying chromatin DNA replication-associated signals in synchronized mammalian cells. We describe steps for cell-cycle enrichment, nucleoside analog-based metabolic labeling, and fluorescence detection. We then detail the procedure for du...

How Many Crystal Structures Do You Need to Trust Your Docking Results?

Abstract Structure-based drug discovery relies on the prediction of protein-bound poses of new molecule designs, the accuracy of which can impact downstream prioritization. While it is expected that crystal structures of similar molecules would provide the best template for predi...

Comparing the bioactivity of grape byproducts (pomace, seed extract, and skin/pulp food coloring) on DSS-induced intestinal stress in early life

According to the 2024 Progress Report for Sustainable Development Goal (SDG) Target 12.3, the call to halve global food waste is rapidly growing out of reach, and immediate action, no matter the perceived scope, is urgently needed. A major opportunity lies in grape pomace (GP)—th...

Responses to the Four Commentators

In response to commentators, I address four questions about my free will skepticism about basically deserved moral responsibility and punishment. Replying to Megan Griffith, I argue that while coherent top-down naturalistic accounts of agency can be developed, the evidence that o...

Tailored speckle illumination microscopy with enhanced sectioning and image quality

Optical speckle patterns have been widely used for illumination in computational imaging, optical sectioning microscopy, and superresolution imaging. However, commonly used speckles satisfy Rayleigh statistics, which are not ideal for diverse imaging applications. Here we tailor...

Controlling Transaction Rate in Tangle Ledger: A Principal Agent Problem Approach

Tangle is a distributed ledger technology that stores data as a directed acyclic graph (DAG). Unlike blockchain, Tangle does not require dedicated miners for its operation; this makes Tangle suitable for Internet of Things (IoT) applications. Distributed ledgers have a built-in t...

Grassland soil bulk density decreases under grazing exclusion and responds asymmetrically to altered precipitation

Soil structure is a key determinant of grassland health and functioning, with bulk density serving as a widely used proxy. Grazing exclusion is a common restoration practice that often reduces soil bulk density in grasslands by restoring plant productivity and removing livestock...

Alzheimer’s disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting more than 55 million people worldwide and is characterized by cognitive decline, amyloid-beta (Aβ) plaques, and neurofibrillary tangles. Although transgenic rodent models have advanced understanding of...

Explainable artificial intelligence for secure and privacy-preserving 5 G networks

Explainable artificial intelligence (XAI) is increasingly relevant to the security, privacy, and governance of AI-enabled 5 G and emerging 6 G networks. However, existing studies remain fragmented across wireless tasks, data modalities, network planes, and evaluation criteria, ma...

Parental Stigma and “Good Parenting” in Child and Adolescent Mental Health

OBJECTIVE: Parents of children with mental health problems often experience judgment about their parenting. Such stigma is associated with lower parental well-being and greater child symptom severity. Theory-driven descriptions of and interventions for parental stigma are limited...

Infection and transmission dynamics of bovine and human influenza A H5N1 viruses in mouse and hamster models

ABSTRACT Here we investigated the pathogenesis and contact transmission of bovine- and human-derived highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b genotype B3.13 viruses in mammalian models. Using reverse genetics, we rescued three naturally occurring viruses, rTX2...