Cornell University

Haplotype phasing of de novo chromosome-level assembly of ‘Antonovka’ facilitated the identification of candidate genes for apple scab resistance

Malus genomic resources with improved quality are becoming an integral part of candidate gene identification and functional validation. Recently, we released a reference-based phased chromosome-level genome assembly of ‘Antonovka’ 172670B Malus domestica cultivar from the ‘Antono...

Commensal bacteria inhibit viral infections via a tryptophan metabolite

Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplored. Here, we define a pathway by which viral inf...

Wnt Pathway Agonism as a Therapeutic Strategy for Retinal Vascular Diseases: A Narrative Review of Evidence to Date

Breakdown of the blood–retinal barrier (BRB) is implicated in many blinding retinal diseases, including diabetic macular edema, neovascular age-related macular degeneration, and retinal vein occlusion. Anti-vascular endothelial growth factor (anti-VEGF) therapies or laser photoco...

Understandingthe Electronic Structure of RutheniumOxides during Redox Cycling with High Energy Resolution X-rayAbsorption Spectroscopy

Abstract Ruthenium oxides are essential catalysts and charge storage materials whose performance across reactions, from the oxygen evolution reaction to the chlor-alkali process, depends critically on reversible Ru redox cycling and the associated electronic structure changes. Al...

MRI Tract‐Based Quantitative Susceptibility Mapping of Limbic White Matter Alterations in Preeclampsia

BACKGROUND: Preeclampsia is associated with long-term cerebrovascular and cognitive risk, but tract-level white matter (WM) involvement remains incompletely characterized. PURPOSE: To investigate whether preeclampsia is associated with tract-level WM susceptibility alterations on...

CAR T cell therapy beyond cancer: current status, challenges and future prospects

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized oncology, and its foundational logic-precise antigen recognition coupled with durable effector activity-extends naturally to chronic non-malignant diseases sustained by long-lived pathological cells. These include...

A Route toPure Optical Rotation in Self-AssembledMaterials through Energetic Nondegeneracy

Abstract Achieving large optical rotation while preserving linear polarization and minimizing loss─“pure” optical rotation─remains a central challenge in chiral photonics. Solution-processed self-assembled materials can exhibit exceptional chiroptical responses (g-factor >...

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...

Middle atmosphere chemical and dynamical effects in the CCMI-2022 stratospheric aerosol injection scenario

Abstract. Stratospheric aerosol injection (SAI) could slow surface warming, however, potential side effects include changes in stratospheric ozone and changes in regional surface temperatures and precipitation resulting from tropical lower stratospheric warming. Previous multi-mo...

Gut microbiota and complications in kidney transplantation: a balancing act between commensal and pathogenic bacteria

PURPOSE OF REVIEW: Recent work has linked gut dysbiosis, an imbalance of commensal and pathogenic bacteria, to complications in kidney transplant recipients. The purpose of this review is to evaluate the gut microbiota's relationship to important complications in kidney transplan...

Above Room Temperature Ferroelectricity in Epitaxially Strained KTaO 3

ABSTRACT Epitaxial strain is a powerful means to engineer emergent phenomena in thin films and heterostructures. Here, we demonstrate that , a cubic perovskite in bulk form, can be epitaxially strained into a highly tunable ferroelectric. films grown commensurate to (001) substra...

Outcomes of Moderate-to-Severe Traumatic Brain Injury in a Low-Resource Setting

Importance: No study from a low- and middle-income country (LMIC) has reported long-term mortality and quality of life (QOL) after moderate to severe traumatic brain injury (msTBI), highlighting its burden and recovery trajectories. Objectives: To measure short- and long-term mor...

Targeting Oncogenic KRAS Using Peptide Nucleic Acid Oligomers Attached to Cell-Penetrating Peptides

Approximately 30% of tumors contain an activating mutation in the oncogene KRAS, leading to increased cell proliferation that often promotes non-small cell lung cancers, colorectal adenocarcinomas, pancreatic ductal adenocarcinomas (PDAC), and other cancers. Among the most common...

ALD with AlternativeCoreactants: Which Work, WhichDo Not, and Why

Abstract In this work, we present a combined experimental and theoretical study that systematically evaluates a series of alcohols (i.e., primary, secondary, and tertiary) as coreactants for trimethylaluminum (TMA)-based atomic layer deposition (ALD) of Al2O3. We employed in situ...

Does TikTok promote or cannibalize music streaming? Estimands and identification with heavy-tailed outcomes

Abstract We study how TikTok affects demand for music on paid streaming platforms in the context of Universal Music Group’s (UMG) global withdrawal of its catalog from TikTok. Recent studies using this quasi-natural experiment have reached different conclusions about whether TikT...

Identification of SKI-II as a host-protective immunomodulator against Staphylococcus aureus infection

ABSTRACT Antibiotic resistance threatens the effectiveness of conventional antimicrobial agents, underscoring the need for host-directed therapies that enhance immune defense. Here, we present a cross-species discovery pipeline that couples a Caenorhabditis elegans–Staphylococcus...

Cytogenetic constraints on hybridization: A meta-analysis investigating the role of chromosome number in monocot hybrid evolution using a newly developed tool, the ploidy deviation index (PDI)

BACKGROUND AND AIMS: Hybridization is a major driver of plant diversity, yet the role of cytogenetic compatibility, particularly differences in chromosome number, remains poorly understood. Differences in parental chromosome number can present barriers to hybrid formation by disr...

Illegal markets for cigarettes and e-cigarettes

This paper discusses the long-standing illegal markets for cigarettes and the more recently emerged illegal markets for e-cigarettes. We identify three distinctive market fundamentals that help explain many features of the illegal markets. First, in contrast to some illegal goods...

Constraint-Based DEM Enhancement Using LiDAR Data at Sparse Highway-Bridge Locations

Abstract Digital elevation models (DEMs) are essential for infrastructure design and flood modeling, yet publicly available DEMs typically exhibit vertical accuracies of one to three meters, insufficient for these applications. This study develops and systematically evaluates a c...

Antibody kinetics against tetanus toxoid before and after primary vaccination of foals

Abstract Background Vaccination recommendations for foals against Clostridium tetani vary. Available studies assessing foal immune responses, maternal antibody interference, or individual variation often used small foal numbers. Objectives To quantify antibody responses after tet...