Chinese Academy of Medical Sciences & Peking Union Medical College

Mechano‐Electrical Coupling Scaffold Drives Bone Organoids Bioenergetic Reprogramming to Accelerate Bone Regeneration

ABSTRACT Critical‐sized bone defects remain a major clinical challenge in orthopedics and regenerative medicine. Bone organoid provided therapy potentials; however, current engineering strategies generally neglect the bioenergetic foundation and intrinsic mechano‐electrical coupl...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Ferroptosis-like cell death induced by Amomi Fructus phenolic compounds in SGC7901 gastric cancer cells: a network pharmacology and experimental validation study

Abstract Background To investigate the mechanism of Amomi Fructus phenolic compounds (AFPC) induced ferroptosis-like cell death in gastric cancer (GC) using a multiomics strategy combining network pharmacology, molecular dynamics simulations (MDS), and experimental validation. Me...

Economic and social modulations of innate decision-making in mice exposed to visual threats

When confronted by predators, animals make innate decisions with rapid reaction times—a trait shaped by natural selection to maximize survival. However, rapid reactions are effective only when grounded in accurate judgments and appropriate choices, which often require cognitive c...

Amyotrophic lateral sclerosis coexisting with primary sjögren’s syndrome: a clinical case series and exploratory transcriptomic analysis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron degeneration, while primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease with prominent immune dysregulation. Although immune-related alterations have been i...

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

Abstract Immune checkpoint blockade (ICB) has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment. Yet, a major barrier to response is that tumor cells are epigenetically reprogrammed to resist immunogenic cell death, particularly pyroptosis. To elucidate how t...

Surgical Technique for Deep Concha, a Pseudomeatus, and High Projection in Congenital Auricular Reconstruction

BACKGROUND: Despite successful cartilage framework construction and auricular elevation in 2-stage reconstruction, achieving adequate conchal cavity depth and auricular projection remains challenging. This study introduces a systematic third-stage refinement technique incorporati...

Topographic analysis of choroidal thickness in pachychoroid disease using ultra-widefield swept-source optical coherence tomography

Purpose To characterise regional and topographic choroidal thickness (CT) profiles using ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) and to compare topographic CT between normal eyes and eyes with pachychoroid disease. Methods All participants underwent...

Endpoint-specific associations of the cholesterol, high-density lipoprotein, and glucose (CHG) index and its adiposity- and inflammation-related derivatives with incident cardiovascular disease and mortality: evidence from CHARLS and NHANES

The cholesterol-high-density lipoprotein–glucose (CHG) index combines lipid and glycemic measures, but whether its adiposity- and inflammation-related derivatives add information beyond their components and established risk factors is uncertain. We compared nine CHG-related indic...

Impact of extreme rainstorm on the spatial distribution of population exposure in Haihe River basin in China

Abstract Based on daily rainfall data from 252 national meteorological stations in the Haihe River Basin of China during 1961–2023, rainstorm events were divided, and four characteristic variables representing the hazard index of rainstorms were statistically analyzed, including...

Gut microbiota-driven hippuric acid hydrolysis promotes pancreatic tumorigenesis by suppressing NK cell activity

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by a lack of effective early detection, profoundly immunosuppressive microenvironment, and poor responsiveness to current therapies. Emerging evidence suggests that gut microbiota a...

Plant-based diet and risk of cognitive decline among older adults: a community-based prospective cohort study

Background: Diet serves as a modifiable risk factor for cognitive decline, yet evidence on plant-based diets and cognitive ageing remains limited. We examined the association between plant-based diets and cognitive decline.Methods: A total of 6,721 participants from the Chinese L...

A de novo IKZF4 Variant Underlies Hypogammaglobulinemia and Increased Infection Susceptibility through Downregulating the NF-κB Pathway

Inborn errors of immunity (IEI) are a group of complex diseases characterized by reduced immunity and increased susceptibility to external pathogens, autoinflammation, autoimmune conditions, and/or malignancy. The IKAROS zinc-finger ( IKZF ) family is a group of C2H2 zinc-finger...

A Hippo-YAP pathway activity-guided multimodal framework highlights NDRG1-associated tumor microenvironmental features in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is characterized by marked molecular and histopathological heterogeneity, which limits the performance of conventional clinicopathological risk stratification systems. Hippo-YAP signaling is closely involved in HCC progression and tumor microenviron...

Occurrence of FLT3 mutations in acute myeloid leukemia and comparison of different methodologies

Fms-like tyrosine kinase 3 (FLT3) mutations occur in approximately 30% of adult patients with acute myeloid leukemia (AML) and are clinically significant for prognosis and targeted therapy. Detection early is essential for treatment decisions. This study evaluated the performance...

Preclinical evidence of neuroprotective effects of endocannabinoids and related lipid molecules in ischemic stroke: a systematic review and meta-analysis of animal studies

Background Ischemic stroke is an acute cerebrovascular disorder caused by interruption of cerebral blood supply, frequently resulting in severe neurological deficits. However, effective therapeutic strategies remain limited. Recent studies have demonstrated that endocannabinoids...

The prognostic value of sarcopenia combined with preoperative C-reactive protein-albumin ratio in patients with gastric signet ring cell carcinoma

Abstract Background Gastric signet ring cell carcinoma (GSRCC) is an aggressive subtype of gastric cancer with poor prognosis. Sarcopenia and systemic inflammation have been linked to adverse outcomes in malignancies. This study aimed to evaluate the prognostic value of sarcopeni...

Contribution of Urbanization and Large‐Scale Warming to Temperature Increase From Pre‐Industrial Revolution Time to Recent Period in Central Beijing City

Abstract The annual mean Surface Air Temperature (SAT) observed during 1757–1762 in central Beijing was 3.1°C lower than that of the nearby Autonomous Weather Stations (AWS) in recent 6 years (2015–2020). The change was much larger than the averaged global warming of the past cen...

Integration of AI-Based Synthetic CT Generation and Auto-Segmentation for CBCT-Guided Adaptive Radiotherapy in Prostate Cancer: A Feasibility Study

Background/Objectives: Adaptive radiotherapy (ART) is essential yet expensive in prostate cancer treatment. This study aims to preliminarily validate the feasibility of an integrated AI workflow for CBCT-guided adaptive radiotherapy in prostate cancer, and to provide a technical...

Discovery of a novel MurA inhibitor via AlphaFold 3 model-based virtual screening

S. aureus is one of the most important bacteria associated with human diseases. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in the synthesis of peptidoglycan in bacterial cell walls. The crystal structure of MurA from S. aureus has...