Chinese Academy of Medical Sciences & Peking Union Medical College

A biodegradable piezoelectric vertebral implant for programmable electro-neuromodulation in spinal cord injury

Spinal cord stimulation has emerged as a promising therapeutic strategy for spinal cord injury (SCI), yet conventional electronic implants remain limited by surgical risk and long-term safety concerns. We introduce a biodegradable piezoelectric cryogel (Piezo Gel) that enables pr...

An ELISA‐Inspired Self‐Propagating Click‐Fluoresce‐and‐Release Assay for the Ultrasensitive Detection of CD13 in Lung Cancer Patient Plasma

ABSTRACT Reaction‐based fluorescent probes often suffer from limited sensitivity in biomarker detection due to slow reaction kinetics and inherent stoichiometric constraints. Inspired by the decoupling of capture and detection in the enzyme‐linked immunosorbent assay (ELISA), we...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

Association of uric acid, lipid and bone metabolic markers with temporomandibular joint osteoarthritis: a cross-sectional study

Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with a complex and multifaceted etiology. Although metabolic disturbances have been linked to osteoarthritis in other joints, their role in TMJOA remains unclear. This study aimed to investigate the associat...

Establishing the role of ZBTB20 mutations in GnRH deficiency and impaired neurogenesis in the subventricular zone: a human cohort and animal model study

Background Congenital hypogonadotropic hypogonadism (CHH) arises from defective development or dysfunction of GnRH neurons. Olfactory bulb (OB) malformations frequently accompany CHH, a condition termed Kallmann syndrome (KS). Nevertheless, approximately 50% of CHH cases remain g...

Cardiac MR Characterization of Infarct‐Related and Remote Myocardial Injury in Multivessel Disease After Acute Myocardial Infarction

BACKGROUND: Patients with multivessel disease (MVD) after acute myocardial infarction (AMI) have worse outcomes than those with single-vessel disease (SVD), but whether MVD is associated with diffuse myocardial injury beyond the infarct zone (IZ) remains unclear. PURPOSE: To char...

Surgical treatment of pancreatic cancer in China: Annual data report of China Pancreas Data Center (2020–2021)

Abstract Objective: The China Pancreas Data Center (CPDC) was established in 2015 with the support of the Chinese Pancreatic Surgery Association, Chinese Society of Surgery, Chinese Medical Association and initiated prospective data collection in 2017. This article reports contem...

Intraoperative titanium clip localization versus preoperative medical glue localization for pulmonary nodules: a prospective cohort study

Preoperative CT-guided percutaneous localization of pulmonary nodules is widely used in clinical practice but is often associated with localization-related complications. Intraoperative titanium clip localization may provide a safer localization strategy. This study aimed to comp...

Development and validation of a questionnaire to assess factors affecting the role effectiveness of intravenous therapy specialist nurses in Beijing, China

Despite the growing workforce of intravenous therapy (IV) specialist nurses in China, substantial underutilization remains a significant challenge. The effective use of IV specialist nurses is influenced by a complex interplay of factors. However, no comprehensive instrument curr...

The EV-A71 RNA-binding protein Matrin 3 facilitates viral replication by stabilizing viral RNA via ZDHHC20-mediated palmitoylation

Enterovirus 71 (EV-A71) is a major causative agent of severe hand, foot, and mouth disease (HFMD) in young children. However, the molecular interplay between EV-A71 and host factors, particularly how these interactions govern viral replication, remains incompletely understood. To...

MINK1 inhibition suppresses triple-negative breast cancer by abrogating ALDOA S39 phosphorylation and reprogramming glucose metabolism

Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, with heightened invasiveness, frequent recurrence and poor prognosis. Deciphering the molecular mechanisms underlying TNBC pathogenesis and drug resistance is critical for developing prec...

LIG4 Syndrome Presenting with Extensive Cutaneous Viral Warts Caused by Multi-Type HPV Infection

Background: DNA Ligase 4 (LIG4) catalyzes the final ligation step during V(D)J recombination. Biallelic pathogenic variants in LIG4 cause severe combined immunodeficiency (SCID), a life-threatening immunodeficiency characterized by the lack of mature T and B cells. Case Presentat...

Signal Detection and Temporal Analysis of Aromatase Inhibitor‐Associated Hepatotoxicity: A Pharmacovigilance Study Integrating Bayesian Belief‐Propagation Network and Frequentist Metrics

ABSTRACT Background This study assessed the real‐world hepatotoxicity of third‐generation aromatase inhibitors (AIs) for breast cancer using pharmacovigilance approaches. Methods FAERS data (Q1 2004–Q1 2025) were analysed using a data‐driven disproportionality analysis framework...

Menopausal arthralgia and longitudinal changes in sex hormones and climacteric symptoms

Musculoskeletal discomfort (menopausal arthralgia) is the most prevalent and debilitating complaint during the menopausal transition. Despite its high prevalence, menopausal arthralgia has historically been overlooked, and establishing a direct association with menopause remains...

Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning

Abstract Large language models (LLMs) have emerged as important tools in healthcare, showing growing potential for clinical reasoning and patient care. This survey examines recent progress in medical LLMs, focusing on reasoning applications and requirements. We present a dual-vie...

An immunohistochemical diagnostic panel for Xp11.2 translocation renal cell carcinoma: A diagnostic accuracy study

Transcription factor binding to IGHM enhancer 3 (TFE3) break-apart fluorescence in situ hybridization (FISH) is the gold standard for the diagnosis of Xp11.2 translocation renal cell carcinoma (tRCC). However, FISH is costly and not accessible in all laboratories. We aimed to dev...

Quantitative Evaluation of Geographic Atrophy Progression Using Geographic Atrophy Lesion Front Displacement

Purpose: To evaluate the temporal behavior and relative variability of a margin-based metric, lesion front displacement, for quantifying geographic atrophy (GA) progression secondary to age-related macular degeneration and to compare its performance with conventional metrics. Met...