Chinese Academy of Medical Sciences & Peking Union Medical College

Integrated Chemical, Computational, and Cellular Profiling of a Dual-Oil Melanoma Formulation: An Exploratory Life-Science Study

Background: Previous studies have examined bioactive constituents of Prunus dulcis oil, Pinus sylvestris essential oil, and related phytochemical matrices separately; however, their combined chemical profile, comparator-context molecular-docking landscape, and comparative cellula...

Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis

Abstract Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited. While RIPK3-mediated necroptos...

Top2a complexes with Trim28 to orchestrate stemness of embryonic stem cells and tumorigenesis

Type II topoisomerase α (Top2a) is crucial for maintaining the stemness of embryonic stem cells (ESCs) and is upregulated in various human cancers, yet the mechanisms underlying its cell type-specific functions remain elusive. Here, using an unbiased proteomic approach, we discov...

Incidence and risk factors for rotator cuff retear after arthroscopic rotator cuff repair in middle-aged and older patients: a systematic review and meta-analysis

Abstract Background Rotator cuff retear remains a major challenge after arthroscopic rotator cuff repair (ARCR), particularly among middle-aged and older patients. This study aimed to investigate the incidence of retear and identify its associated risk factors in this patient pop...

Chinese expert consensus on extraintestinal manifestations of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory condition of the gastrointestinal tract that primarily includes Crohn's disease and ulcerative colitis. Beyond the typical gastrointestinal symptoms, IBD is frequently associated with various extraintestinal m...

Distinctive subcortical connectivity predicts treatment response in first-episode schizophrenia

Background Subcortical regions are widely implicated in the pathological mechanisms and treatment of schizophrenia, and accumulating evidence, including our prior findings, suggests that subcortical functional dysconnectivity is closely associated with treatment response. Accordi...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...

Numerical and Interpretive Comparability of Optical and Mechanical Coagulation Analyzers: A Zlog-Supported Method Comparison Study

Background/Objectives: In laboratories using coagulation analyzers with different clot-detection principles and platform-specific reference intervals (RIs), numerical agreement does not necessarily ensure concordant clinical interpretation. We evaluated how analytical agreement a...

A novel distal radial artery compression device versus elastic bandage compression after coronary angiography or percutaneous coronary intervention via distal transradial access: a prospective randomized controlled trial

Distal transradial artery access (dTRA) is increasingly used for coronary interventions because it preserves proximal radial artery patency. However, effective hemostasis at the distal puncture site remains challenging due to the superficial vessel location and limited soft-tissu...

Burden of Crohn’s disease in East Asia: a 34-year analysis with projections to 2060

Abstract Purpose Crohn’s disease has transitioned from a rare condition to a significant public health concern in East Asia, yet comparative evidence across countries and long-term projections remain limited. We assess national trends in the burden of Crohn’s disease in China, Ja...

BCMA CAR T-cell therapy in a patient with heavily pretreated relapsed/refractory POEMS Syndrome: a case report

Abstract B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR T-cell) therapy is an established treatment for relapsed/refractory multiple myeloma. However, its application in POEMS syndrome remains largely unreported, despite overlapping pathogenesis involving...

Oral anticoagulation therapy in nonagenarian patients with atrial fibrillation: usage patterns, predictors, and in-hospital outcomes from a single-center retrospective study

Abstract Background Atrial fibrillation (AF) is highly prevalent in nonagenarians (≥ 90 years). However, this group is often excluded from clinical trials, leaving limited real-world evidence on oral anticoagulant (OAC) use, safety, and efficacy. This study sought to investigate...

Visual Outcomes and Patient-Reported Dysphotopsia After PanOptix and PanOptix Toric Implantation Stratified by Preoperative Chord Mu: A Prospective Observational Cohort Study

We aimed to evaluate the tolerance of preoperative chord mu (angle kappa) after cataract or clear lens exchange surgery and implantation of AcrySof IQ PanOptix and PanOptix Toric in a Chinese cohort. This prospective observational study consecutively enrolled patients undergoing...

Benchmarking RNA-seq with the Quartet and MAQC reference materials to establish best practices for accurate alternative splicing analysis

Previous limited characterization of short-read RNA-seq (srRNA-seq) accuracy in alternative splicing (AS) analysis due to methodological diversity and lack of reference standards, has left unclear how to achieve optimal performance—an issue increasingly critical with the rise of...

Burden of pancreatic cancer in China and the United States, 1990–2023

Abstract Objective: Pancreatic cancer (PC) remains a major global health burden characterized by high mortality and substantial socioeconomic inequality. This study compared long-term trends, inequality patterns, and risk-factor transitions of PC burden in China and the United St...

Menarche, menopause, reproductive life span and menopause-specific quality of life: a cohort study

Objective This study aimed to investigate the associations of menarche age, menopause age and reproductive life span with menopausal symptoms in Chinese women.Methods The prospective, longitudinal study included 557 midlife Chinese women. Menopausal symptoms were evaluated throug...

An ELISA‐Inspired Self‐Propagating Click‐Fluoresce‐and‐Release Assay for the Ultrasensitive Detection of CD13 in Lung Cancer Patient Plasma

ABSTRACT Reaction‐based fluorescent probes often suffer from limited sensitivity in biomarker detection due to slow reaction kinetics and inherent stoichiometric constraints. Inspired by the decoupling of capture and detection in the enzyme‐linked immunosorbent assay (ELISA), we...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...

Cosmetic parameters associated with SRS-22r improvement postoperatively in patients with adolescent idiopathic scoliosis: a 2-year follow-up

Adolescent idiopathic scoliosis (AIS) significantly impacts physical appearance and quality of life. This exploratory study aims to investigate potential association between cosmetic parameters and minimal clinical improvement in SRS-22r scores at a 2-year follow-up in AIS patien...

Endothelial Bmal1 coordinates intrinsic and paracrine mechanisms to limit post-injury vascular restenosis

Circadian rhythms have been implicated in the regulation of cardiovascular physiology and disease. Disruption of circadian signaling has been linked to exaggerated neointimal hyperplasia and delayed endothelial repair. Bmal1, a core component of the molecular clock, plays a criti...