Centre National de la Recherche Scientifique

Bony labyrinth taxonomic identification and long-term evolution of livestock in the Southwest and Central Asia

Abstract Southwest and Central Asia were pivotal regions for the domestication and dispersal of domestic herbivores. Here we investigate long-term variation in bony labyrinth morphology of domestic bovids (sheep, goats and cattle) across the last 10 000 years. We focused on the o...

A cytidine deaminase biodegrader sensitises multiple cancer types to deoxycytidine analogue-based chemotherapies

Abstract Deoxycytidine (dC) analogues are widely used to treat solid tumours and blood cancers. However, their clinical efficacy is often limited by resistance mediated by cytidine deaminase (CDA), which converts these drugs into inactive metabolites. Existing CDA inhibitors have...

Distributed Phase-Shedding: A Scalable Solution for Automotive Microprocessor Power Supplies

The increasing computing power required by autonomous vehicles imposes stringent requirements on automotive microprocessor power supplies in terms of efficiency, scalability, and fault tolerance. Conventional phase-shedding strategies for multiphase converters rely on centralized...

Self-assembled nucleolipid G-quadruplexes act as multitarget decoys for oncogene suppression in pancreatic cancer

Abstract KRAS mutations drive multiple cancers and represent an important therapeutic target, together with other oncogenic regulators such as MYC , KIT , and BCL2 that are critically involved in pancreatic cancer. Here we describe a novel therapeutic strategy based on stable nuc...

Probable vestibular paroxysmia mimicking benign paroxysmal positional vertigo of the superior semicircular canal in the presence of a neurovascular conflict: a case report and review of the literature

Positional vertigo is a frequent complaint in otology and vestibular physiotherapy, arising from functional or structural causes affecting the peripheral or central vestibular systems. Although benign paroxysmal positional vertigo (BPPV) is the most common form, other etiologies...

Collective adsorption of pheromones at the water–air interface

Abstract Understanding the phase behaviour of pheromones and other messaging molecules remains a significant and largely unexplored challenge, even though it plays a central role in chemical communication. Here, we present all-atom molecular dynamics simulations to investigate th...

Embryos resolve the enigmatic origin of the theropod wishbone

The origin of the avian wishbone (furcula)—present since theropod dinosaurs—remains unsolved. Its homology is still debated, with competing hypotheses proposing derivation from the clavicles, the interclavicle, or both. To obtain comparative developmental evidence, we studied oss...

Flexibility of the TRMT10C N-Terminal Domain Helix Explored by Molecular Dynamics Simulations

Abstract The human mitochondrial tRNA methyltransferase TRMT10C contains a 41-residue long positively charged α-helix in its N-terminal domain, interacting with tRNAs from the anticodon to the T-loops. Here, we investigated the flexibility of this N-terminal long α-helix using co...

Clinical and ecological significance of bacterial dormancy in human pathogens

SUMMARY Bacteria can enter a transient state of reduced metabolic activity to survive temporary unfavorable conditions. This phenomenon, sometimes referred to as dormancy, growth arrest, or quiescence, enables pathogen survival inside and outside of their host, with major clinica...

Guided elastic waves informed material modelling of soft incompressible media

Abstract Identifying a universal material constitutive law which describes the mechanical response of rubber-like solids for all deformation fields and achievable extensions, is an outstanding challenge. Here, we propose to exploit the propagation of elastic waves and demonstrate...

Changes in students’ self-perceived interprofessional collaborative skills following participation in the student health service program

Interprofessional collaboration is recognized as a key component of effective healthcare systems. In France, the Student Health Service (SHS) is the only mandatory and universal interprofessional training experience in health curricula. However, evidence regarding its impact on i...

Validation of a new morphological diagnostic criterion in Mauritian giant tortoises of the genus Cylindraspis ( Cryptodira, Testudinidae ) thanks to paleoproteomics

A collection of Cylindraspis Fitzinger, 1835, subfossils from Mare aux Songes (Mauritius, 4,200 years BP) has recently been described. At the end of this preliminary description, only some of the 216 tortoise bones could be identified using anatomical criteria and the question of...

Assessment of infection prevention practices in office-based surgery: a multicentre regional audit

Abstract Background Office-based surgery (OBS) is increasingly used due to organizational constraints and perceived benefits. However, data on infection prevention and control (IPC) practices in OBS settings remain limited. This study aimed to assess the conditions in which OBS a...

Improved estimation of net ecosystem CO 2 exchange over North America using LSTM-based flux upscaling (2001–2021)

Accurate estimation of regional-scale terrestrial carbon budgets is of great importance but remains challenging. With particular advantages, the Long Short-Term Memory (LSTM) network method shows potential for improving regional carbon budget upscaling estimations. Here, using LS...

Long-term preservation of early-formed silicate reservoirs in the deep mantle: New insight from 146Sm-142Nd systematics in Hawaiian basalts

Short-lived radiogenic isotope systems provide unique constraints on the preservation of early-formed reservoirs in Earth's mantle. We present the largest high-precision μ 142 Nd dataset for a single hotspot, comprising 55 analyses of 29 shield-stage tholeiitic basalts from the H...

Concurrent synchronization and covariation in upper extremity joint angles during a reciprocal aiming task

Abstract The ecological-dynamical approach holds that movement is self-organized, implying a circular causality between the kinematics of the end-effector and the coordination of degrees of freedom (DOF) into synergies. Yet, how this circular causality manifests itself in redunda...

Experimental impact study on a micro-grid project in rural Madagascar: The Café Lumière project

This paper evaluates the impact of a pilot innovative project aiming at promoting a replicable model to create access to distributed electricity in rural areas where grid extension is economically infeasible. The project proposes building solar-powered micro-grids to provide affo...

Computational identification and experimental validation of early glycinergic impairments in spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disorder characterized by lower motor neuron (MN) loss, due to mutations or deletions in the Survival Motor Neuron 1 ( SMN1 ) gene. Increasing evidence implies mitochondrial dysfunctions in SMA, suggesting these org...

Scanning and active sampling behaviours emerge from conserved insect neural circuits

Navigating insects often pause and rotate to sample their surroundings, behaviours termed scanning. These and other active sampling behaviours embody navigational uncertainty and are key for spatial learning, yet their neural basis remains unclear and existing models impose scann...

Adoption of, attitudes towards, and perceived challenges of digital health in hospice and palliative care among professionals in Germany: a national cross-sectional web-based survey

Abstract Background Digital health technologies may support communication, symptom management, continuity of care, and access to services in hospice and palliative care. National data on their adoption, on professionals’ attitudes, and on perceived barriers are scarce. We examine...