Centre National de la Recherche Scientifique

Trions as Fundamental Species in Chemically Doped Polymer Semiconductors

Doping is a cornerstone strategy for enhancing charge transport in semiconducting polymers, important for their application in, for example, semi-transparent electrode materials, thermoelectric devices, and antistatic coatings. Both chemical and electrochemical doping have, for t...

Cuprous Ions Binding to Cytosine and Guanine Oligonucleotides

Using a set of spectroscopic experiments, we investigated the binding of Cu 2+ and Cu + to a comprehensive series of nucleic acid‐related molecules, ranging from individual nucleobases to oligonucleotides up to six nucleotides in length. We demonstrate the selective binding of Cu...

Identification of a membrane transporter for dimethylsulfoniopropionate uptake in marine eukaryotic phytoplankton

Marine microalgae obtain essential sulfur through energetically costly, assimilatory reduction of sea-salt sulfate, so the ability for osmotrophic incorporation of reduced sulfur would confer them adaptability in energy-limiting conditions. Dimethylsulfoniopropionate (DMSP) is a...

Transient Cytoskeletal Anisotropy Encodes Short‐Term Mechanical Memory in Glioblastoma Cells

ABSTRACT Cells experience time‐varying mechanical cues when navigating complex microenvironments, yet whether and how they retain a short‐term memory of recent deformations remains unclear. Here, we show that glioblastoma cells encode such memory through transient cytoskeletal an...

Molecular Rotors: From Newtonian Fluids to Functional Materials as Viscosity and Temperature Sensing Tools

ABSTRACT Molecular rotors (MRs) are a distinctive class of fluorescent molecules whose photophysical properties are influenced by their surrounding environment, making them valuable as viscosity nanosensors. However, interpreting their fluorescence responses in complex systems po...

Seasonal dependence of temperate forest soil respiration to soil temperature and water content clarified through data-driven modeling

Soil respiration is commonly modelled as a function of soil temperature and soil moisture, without explicitly accounting for seasonal effects. We have therefore developed a data-driven model that integrates interactions among soil temperature, soil moisture, and seasonality. This...

PercolationMechanisms in Transient Polymer Networksacross Dilute and Semidilute Regimes

Abstract Percolation in transient polymer networks remains poorly understood because reversible cross-links continuously reorganize the network structure. In this study, we investigated percolation in transient polymer networks by independently controlling network connectivity an...

Validation and Spin of the Bright Part of Gaia DR2 and DR3

ABSTRACT The Gaia Data Release 3 (DR3) is an important step in the realization of the future Gaia reference frame. Ideally, across G magnitudes from 3 to 21, the Gaia DR2 and DR3 objects with their positions (, ) and proper motions (, ) should be expressed in a nonrotating refere...

Characterising recent antimalarial resistance in West Africa: Insights from amplicon sequencing of 17,384 Plasmodium falciparum infection samples

<ns5:p> Background <ns5:italic>Plasmodium falciparum</ns5:italic> ( <ns5:italic>P. falciparum</ns5:italic> ) infection remains a significant public health threat in West Africa, where chemoprevention and first-line therapies are key interventions against malaria. However, the dev...

Bioelectrical Impedance in Cardiovascular Health

Bioelectrical impedance (BI) is gaining significant attention for its potential in cardiovascular health monitoring and early disease detection. On the basis of the principles of tissue conductivity and body composition, BI operates by applying a low-amplitude alternating current...

Altered excitation-inhibition balance in the somatomotor and default mode network in multiple sclerosis

Excitation-Inhibition (E/I) balance is a system-level principle governing healthy neuronal information processing. Its disruption has been implicated in the pathophysiology of multiple sclerosis (MS), yet in vivo characterization of E/I balance in MS remains under debate. In MS,...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

DNTTIP2 coordinates RNA exosome activities to ensure fidelity of human ribosome assembly

Abstract The RNA exosome-associated helicase Mtr4/MTR4 (yeast/human) is recruited by adaptor proteins bearing Arch-Interacting Motifs (AIMs) to selectively degrade RNA substrates. Although the exosome targets diverse RNAs, only a few adaptors have been identified. Here, we extend...

Electrical control of exchange bias in sub-10 nm regime enabled by single-nanotube patterning

Achieving stable magnetization in sub-10 nm ferromagnetic layers represents a fundamental bottleneck in spin-orbit torque magnetic random-access memory development. While exchange bias potentially offers stabilization at such scales through antiferromagnetic coupling, conventiona...

Coordinative chain transfer homopolymerization and copolymerization of bio‐sourced β ‐myrcene and butadiene promoted by iminopyridine iron complexes

Abstract A family of iron complexes bearing iminopyridine (ImPy) ligands with systematic variations on the N ‐aryl and pyridine moieties was evaluated as pre‐catalysts for the coordinative polymerization of β‐myrcene and butadiene. Upon activation with Al i Bu 3 and trityl borate...

The postsynaptic scaffolding protein SAPAP3 shapes mitochondrial activity: the case of Huntington’s disease

Abstract Postsynaptic scaffolding protein SAP90/PSD95-associated protein 3 (SAPAP3) modulates cortico-striatal signalling and regulates the maintenance of synaptic structure. Notably, SAPAP3 defects have been reported in several human psychiatric disorders that share pathophysiol...

Melt burst events in a dominantly amagmatic lithosphere at Gakkel Ridge in the Arctic Ocean

Abstract Alternation of magmatic and amagmatic seafloor along the slow and ultraslow spreading ridges is common. Yet, temporal variation is obscured by sediments blanketing oceanic basement away from spreading centers. Here we analyze aeromagnetic data covering zero age to ~35 Ma...

Microencapsulation of Araucaria angustifolia bract extract: protection and bioaccessibility of phenolic compounds in chitosan-based systems

Abstract Purpose Native to South America, Araucaria angustifolia bracts (an underutilized by-product of seed processing) account for nearly 80% of the pinecone and are commonly discarded. The lyophilized aqueous extract obtained from these residues is rich in phenolic compounds (...

Rational Molecular Design to Improve Digital Polymer Readout in Aerolysin‐Based Nanopore Sequencing

ABSTRACT Nanopore sequencing is a promising method for decoding synthetic digital polymers, but translocation signals are often complex. This study examines the influence of macromolecular design on the accuracy of nanopore sequencing. Nine phosphoramidite monomers were synthesiz...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...