Centre National de la Recherche Scientifique

Paclitaxel-loaded nanostructured lipid carriers surface-functionalized with N6L for pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies, with limited therapeutic options. Despite advances in chemotherapy, such as FOLFIRINOX and Abraxane® (nab-paclitaxel) combined with gemcitabine, these treatments show limited effic...

SARS-COv-2, influenza and other respiratory virus co-circulation during an outbreak in a rural health zone in Democratic Republic of Congo, 2024–2025

Little is known about the global impact of co-circulation and co-infection of COVID-19 and influenza in Democratic Republic of the Congo (DRC). This study aims at analyzing data on SARS-CoV-2, influenza and other respiratory viruses collected during an outbreak response in the ru...

STABILOOP, a cohort trial to assess automated insulin delivery in the management of patients living with type 1 diabetes who are eligible for islet transplantation

A limited subset of people living with type 1 diabetes (T1D) is affected by extreme glycemic lability and frequent unpredictable severe hypoglycemia, significantly impairing quality of life and associated with higher morbidity, mortality, and healthcare costs. Islet transplantati...

Accelerating biomass loss from forest disturbances across Europe

Abstract Forest disturbances are rising globally due to climate change and land-use pressures, weakening the terrestrial carbon sink. However, declines in aboveground biomass from tree cover loss remain poorly quantified, limiting our understanding of the role of disturbances in...

Quantifying the Gap Between the Local Perceptions of Farming Households and What Experts Say About Climate Change in Haiti and the Dominican Republic

This study quantifies and assesses the gap between the perceptions of 550 farming households on the Caribbean island of Hispaniola and the opinions of 60 regional experts on climate change. This quantification draws on the traditional knowledge of farming households, which is bas...

Hydration-dependent exciton-phonon coupling in a metal-organic framework photocatalyst

Abstract Metal-organic frameworks (MOFs) have potential for light-harvesting applications owing to their tunable optoelectronic properties via building block selection. The presence of bound solvent in MOFs is known to impact gas adsorption properties, but little is known about t...

Dissent enhances the credibility of groups of Bayesian conformist decision-makers

When making a decision, individuals use their private information to evaluate the available options. In a group, they can also learn from other group members' choices, which partially reveal their own private information. Bayesian estimation provides tools for modelling decisions...

Urban transit experimentation as a mega-event legacy: public security in railway stations at the Paris 2024 Olympic Games

The urban sites of sport mega-events, such as the World Cup or the Olympic and Paralympic Games, have become stages for experimenting with extraordinary security and safety procedures. These procedures are designed to demonstrate the host country’s capacity to mobilize in the fac...

Guidelines for Studying Mutagenesis in Quiescent Schizosaccharomyces pombe

All living organisms can enter a non-dividing state known as quiescence, which often functions as a survival strategy. In many cases, quiescent cells retain the ability to re-enter the cell cycle when conditions become favorable. Therefore, preserving the integrity of non-dividin...

Agronomic and socio-economic assessments of the roles of earthworms and termite mounds in paddy fields

Bioturbation, the physical disturbance and mixing of soil layers caused by the activity of living organisms, such as earthworms and termites, plays a critical role in shaping soil structure, enhancing nutrient cycling, and regulating ecosystem dynamics. In paddy fields, earthworm...

Case report of transoral excision of a right buccal/jugal lipoma

Introduction: Lipomas are benign mesenchymal tumors that rarely occur in the oral cavity. Lesions arising in the jugal region may pose diagnostic and surgical challenges due to their anatomical location. We report a case of a jugal lipoma successfully managed through a transoral...

Nonfermenting Gram-Negative Bacilli Other Than Pseudomonas and Acinetobacter Species in Pediatric Blood Cultures: A Multicenter European Analysis

BACKGROUND: Nonfermenting Gram-negative bacilli other than Pseudomonas and Acinetobacter species are increasingly recognized as opportunistic pathogens in pediatric populations, yet their epidemiology and antimicrobial resistance remain poorly defined. METHODS: We conducted a mul...

A Blockchain-Based Tokenize–Track–Trace (3T) Architecture for Oracle-Anchored Supply Chain Traceability Using Dynamic NFTs and Smart Contracts

This paper introduces an approach based on blockchain and dynamic Non-Fungible Tokens (dNFTs) for transparent supply chain management (SCM) through end-to-end traceability and automation. The approach addresses three recurring limitations of blockchain-enabled SCM: physical-to-di...

Imperfect detection and sampling effort shape ground beetle (Carabidae) diversity indicators in large-scale monitoring

Soil biodiversity indicators are increasingly used to inform environmental assessment and policy, yet their robustness is often constrained by heterogeneous sampling designs and imperfect species detection. Surface-active arthropods, such as ground beetles (Carabidae), are widely...

No gender differences in predictive processing

Abstract Statistical learning, defined as the implicit extraction of environmental regularities, is considered a fundamental cognitive mechanism that supports predictive processing across individuals, domains, and species. However, whether it is modulated by gender remains unclea...

Peptide-targeted cubosome and hexosome nanoassemblies mitigate mitochondrial dysfunction in a MitoPark model

Mitochondrial dysfunction is a primary pathogenic mechanism underlying dopaminergic neuron loss in the nigrostriatal pathway in Parkinson's disease (PD). To investigate mitochondrion-targeted therapeutic strategies, we utilized the MitoPark mouse model, in which mitochondrial tra...

Topologically Engineered DNA Origami: Responsive Locking of DNA Quadrilateral for Biosensing Application

Abstract DNA nanotechnology offers unique opportunities for creating various accurate and responsive nanostructures. Nevertheless, large-scale conformational changes with high geometric precision and efficiency remain major challenges. Herein we report a topologically engineered...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Contribution of One‐Electron Oxidation of Purine and Pyrimidine Bases to the Photo‐ and Radiation‐Induced Damage to Cellular DNA

One‐electron oxidants that include type I photosensitizers, biologically relevant carbonate anion radical generators, and high intensity UVC nanosecond lasers are able to ionize in aqueous solution purine and pyrimidine nucleobases. The survey is aimed at critically reviewing the...

Chemical desorption of methanol induced by hydrogen abstraction–addition cycles on cold grain surfaces

Abstract We report ultra-high vacuum experiments on the non-thermal desorption of methanol (CH3OH) from cold dust-grain analogues under hydrogen-atom bombardment. Monolayer methanol films on polycrystalline gold, compact amorphous solid water (ASW, 10 ML) and 13CO ice (2 ML) are...