Centre National de la Recherche Scientifique

Targeting the Complement C1 Proteases Using Camelid-Derived Single Domain Antibodies: Production, Characterization and Possible Application for Tissue/Fluid Analysis

Background. The complement C1r and C1s proteases initiate the classical complement pathway within the C1 complex, but emerging evidence points to additional roles in tissues, including cell-intrinsic functions linked to cancer and connective tissue disorders. Few tools are availa...

NKCC1 coordinates SPAK-PP1 signalling to regulate KCC2 membrane stability and seizure susceptibility.

Chloride homeostasis, and thereby the efficacy of chloride-permeable GABAA receptor signaling, depends on the dynamic balance between NKCC1 (Na+-K+-2Cl- cotransporter 1) and KCC2 (K+-Cl- cotransporter 2), which respectively mediate chloride influx and extrusion to tightly control...

Trace elements analysis of 16th-century silver coins minted in Nantes - coupled HE-PIXE and p-XRF measurements

Previous studies have identified the origin of silver extracted from South American mines -Mexico and Potosí- and its circulation through trade between Spain and France during the second half of the 16th century. In this context, a selection of silver coins minted in Nantes was a...

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

The tumor microenvironment (TME) is a complex and heterogeneous milieu encompassing biological and biochemical events and diverse physical, chemical, and mechanical interactions between tumor and stromal cells. This heterogeneity plays a pivotal role in regulating tumor progressi...

Approximation of adelic divisors and equidistribution of small points

Abstract We study the asymptotic distribution of the Galois orbits of generic sequences of algebraic points of small height in a projective variety over a number field. Our main result is a generalization of Yuan’s equidistribution theorem that applies to heights for which Zhang’...

Rapid estimation of structural brain disconnection from binary lesion masks using DeepDisco

Abstract Mapping how focal brain lesions disrupt structural connectivity is key to understanding cognition, behavior, and neurological outcomes. However, traditional diffusion tractography pipelines are computationally intensive, require specialized data and expertise, and remain...

Dynamics of charge fluctuations in nanocapacitors: Effects of salt concentration and electrode metallicity from Brownian dynamics

Electric double-layer capacitors (EDLCs) rely on the dynamical response of confined electrolytes to store and release charge, yet the interplay between ion transport, electrostatic interactions, and electrode metallicity remains poorly understood at the nanoscale. In this work, w...

Spatiotemporal variation of the chick mass-brood size trade-off in the little owl

Abstract Resources are limited and cannot be used for multiple functions simultaneously, leading to trade-offs between life-history traits. The detection of such trade-offs depends on resource acquisition (total amount of resources) and allocation (distribution of resources betwe...

Interface engineered perpendicular magnetic anisotropy-controlled propagation of magnetic domain

We report the impact of ferromagnetic layer thickness and stack configuration on the magnetic properties, perpendicular magnetic anisotropy (PMA), modified magnetization switching mechanisms, and creep regime domain wall (DW) dynamics, including their propagation velocity, in a P...

Consistent estimates of carbonyl sulfide and methane stratospheric lifetimes retrieved from AirCore profiles at different latitudes

Stratospheric loss is a major sink for both carbonyl sulfide (COS) and methane (CH 4 ), but their stratospheric lifetimes and sinks remain poorly constrained because high-resolution observations of their vertical distributions in the lower stratosphere are sparse. Here, we estima...

Weighting of Spectral and Temporal Cues with n-of-m Cochlear Implant Strategies Depends on Voice Pitch

Abstract Purpose The relative contributions of spectral and temporal cues to voice pitch perception in cochlear implant (CI) users remain unclear. This study aimed to directly quantify these contributions in dynamic speech stimuli with clinical n -of- m processors. Methods Fundam...

Protocol for integrative transcriptomic/metabolomic analysis: A case study on factors influencing the oyster-POMS disease

Deciphering the molecular mechanisms underlying complex biological interactions requires comprehensive approaches that capture these interactions across multiple regulatory and functional levels. Here, we present a protocol applied to the host-pathogen-environment interactions un...

A family of small proteins links c-di-GMP riboswitch signaling with sporulation in Clostridioides difficile

Abstract Cyclic diguanosine monophosphate (c-di-GMP) is a second messenger that coordinates lifestyle transitions, virulence, and developmental processes in bacteria. In Clostridioides difficile , elevated c-di-GMP levels inhibit sporulation, but the underlying mechanism remained...

Estimating isotopic turnover rates using DEB theory

The isotopic turnover rate (λ) quantifies the rate at which an organism’s tissues are renewed. It is a key parameter in dietary studies as it governs predator-prey dynamics and by extension the broader food web. However, λ has historically been difficult to estimate, typically re...

Ultrafast Micrometric Laser Structuring of Polymer Surfaces for Highly Organized Skeletal Muscle Tissue Modeling

ABSTRACT Engineered surface topographies have proven to be an efficient method to replicate in vitro the architecture of highly organized tissues by controlling the spatial arrangement of cells. In this work, we studied the ability to guide muscle cell development using femtoseco...

Foreign aid and power play: Political cycles in world bank’s procurement allocation

This paper examines the existence of political cycles in the awarding of World Bank procurement contracts around elections. We analyze elections in the home country of firms winning these contracts, distinguishing between firms based in the aid recipient country (i.e., domestic f...

Wild-type and mutated ß-catenin differently repress RND3/RHOE expression in hepatocellular carcinoma

Tumor development and progression are mainly driven by oncogenic mutations but are also regulated by physical factors. Through its structural and transcriptional functions, ß-catenin is a key factor that acts on both aspects to promote liver tumorigenesis, leading to hepatocellul...

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

Estradiol (E2) regulates ovarian follicular development and granulosa cell (GC) function primarily through estrogen receptor β (ERβ). Human GCs express several ERβ isoforms, including ERβ1, ERβ2, ERβ4, and ERβ5, but how their relative abundance modulates estrogen signaling remain...

A multiday outdoor festival combining breathwork and cold water immersion is associated with reduced trait anxiety in a naturalistic pre-post study

Abstract Breathwork and cold exposure attract growing public interest, yet little is known about their psychological effects in real-world multi-day formats, and most evidence concerns acute physiological or state-level outcomes rather than more dispositional markers. This natura...

Calcium Isotopic Composition in Reindeer ( Rangifer tarandus ) Bones and Tooth Enamel: A Scalable Tool to Quantify Nursing Frequency in Past and Modern Populations?

RATIONALE: Populations of North American caribou and Eurasian reindeer (Rangifer tarandus sspp.), essential for Arctic ecosystems and human communities, are experiencing unprecedented declines due to climate change and anthropogenic pressures. While understanding their historical...