Centre National de la Recherche Scientifique

The skin of sorrow. The controversies between protected areas and tourism in a context of glacial retreat: Grande Motte (Tignes) and Girose (La Grave), France

The aim of this article is to identify the sources and drivers of conflict and conciliation in the case of two glacier redevelopment projects, drawn up in response to operating difficulties caused by climate change–driven glacial retreat and the declining popularity of summer ski...

CRISPR screens reveal MCT1-driven metabolic escape from SMAD3 inhibition as a therapeutic vulnerability

Resistance to therapy remains a critical challenge in cancer. This is exemplified by TGF-β pathway inhibitors which, despite broad clinical testing, have failed to deliver survival benefit. More precise SMAD3 targeting has shown preclinical promise, yet resistance mechanisms to S...

Scalable Synthesisof a Masked Thiophenol as an Air-Stable,Odorless Intermediate to the Aurora Kinase Inhibitor Tozasertib (VX-680)

Abstract The use of thiophenols on process scales is fraught with challenges relating to their toxicity, malodor, and air sensitivity. We previously demonstrated that the Ni-catalyzed C–S coupling of aryl iodides and thiourea provides a discovery-scale route to S-aryl isothiouron...

Pressure-SelectiveMagnetic Switching via SpatiallySeparated Soft Interlayer and Rigid Charge-Transfer Intralayer

Abstract We report a pressure-responsive molecule-based magnet featuring a layered cyanido-bridged Co–W assembly, [{CoII(4-phenoxypyridine)4}3{WV(CN)8}2], exhibiting a distinct pressure-selective magnetic behavior. The compound forms two-dimensional charge-transfer layers with la...

Drainage divide dynamics modulated by erosion-driven landscape adjustment in a low-deformation setting

The Vosges Mountains (northeast France) are a mid-altitude mountain range with peaks reaching ∼1500 m a.s.l., in a low-deformation setting. Despite this, they maintain significant topographic relief (up to ∼1000 m), characterized by deeply incised valleys and broad, rounded uplan...

Effects of home-based videoconference adapted physical activity on healthy aging

Abstract Aging induces muscle weakness and power decline in older adults, increasing the risk of falls. Adapted physical activity (APA) programs are effective in mitigating these declines. Recent innovations, including videoconferencing, offer alternative delivery modes, but thei...

Queen loss fails to elicit physiological and transcriptional responses in workers of the invasive garden ant Lasius neglectus.

Colonies of insects with morphologically distinct castes have been called superorganisms because the function of their queens and workers is analogous to the germline and soma in metazoan bodies. In the case of formicoid ants, workers typically have lost the sperm storage organ,...

Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas

ABSTRACT Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion are key molecular markers for glioma classification. Amide proton transfer weighted (APTw) and nuclear Overhauser effect–weighted (NOEw) markers showed promise for glioma characterization, by probing protein‐r...

EvolutionaryConvergence on a Dihydrofolate ReductaseMutation Drives Trimethoprim–Sulfamethoxazole Resistance in Burkholderia thailandensis

Abstract Trimethoprim–sulfamethoxazole (SXT) remains central to melioidosis eradication therapy, yet the genetic basis of resistance evolution in Burkholderia pseudomallei is not fully defined. Using Burkholderia thailandensis as a biosafe surrogate, we subjected populations to s...

Scaling up fabrication of thin-film nanocomposite (TFN) membranes: Methods, challenges, and applications

Abstract Thin-film nanocomposite (TFN) membranes have received significant attention because of their excellent separation performance, structural flexibility, and tunability. As the demand for high-efficiency membrane technologies in industry grows, it becomes imperative to tran...

Dietary behaviour of Sepedon (Parasepedon) ruficeps and Sepedon (Sepedomyia) nasuta (Diptera: Sciomyzidae) and the distribution of their snail prey in Benin (West Africa)

Sciomyzidae (Diptera) larvae live as predators and/or parasitoids of snails. They have potential economic importance as biological control agents against gastropods that are vectors of parasitic diseases. In the present study, the use of Sepedon larvae in schistosomiasis control...

Improving ADRC Strategy for DC-Link Voltage Regulation in PV Grid-Tied Four-Leg Inverters Using an Adaptive Nonlinear High-Gain Observer

In practical photovoltaic grid-tied four-leg inverter systems (PV-GTFLIs), changes in radiation, temperature, and grid voltage magnitude cause significant disturbances, including DC-link voltage disturbance and power unbalance, which can impact the system’s dynamic responses, con...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

The rise of carnivoran mammals in Europe through the lens of body mass

Carnivoran mammals (cats, dogs, bears, seals, etc.) and their kin radiated during the Palaeogene, among other carnivorous clades (hyaenodonts, mesonychians, and oxyaenodonts). This radiation has often been framed as a competition ultimately won by carnivorans, but the data suppor...

Pseudomonas aeruginosa mgtC gene is under the control of PhoP and CbrAB regulators, and its expression can be visualized in macrophages

ABSTRACT The MgtC virulence factor is important during the intramacrophage stage in both classical intracellular pathogens, such as Salmonella Typhimurium, and in extracellular bacteria that transiently encounter intracellular environments during infection, such as Pseudomonas ae...

Empirical evidence for a trade-off between reproduction and tumour dynamics in the freshwater cnidarian Hydra oligactis

Abstract Reproduction is a key life-history trait but often comes at the expense of somatic maintenance, including ageing and susceptibility to disease. While reproduction–immunity trade-offs have been experimentally demonstrated in the context of infectious diseases, whether rep...

Visual Pathways Involvement in Friedreich’s Ataxia Patients Without Macular Impairment

Objectives: Visual Evoked Potential (VEP) abnormalities in Friedreich Ataxia (FA) may result from dysfunction of retinal ganglion cells (RGC), post-retinal visual pathways, or both. Therefore, we aimed to clarify whether in Friedreich Ataxia (FA), abnormal neural conduction is du...

The One-Dimensional Compressible Navier–Stokes Equations in Critical Regularity Spaces

Abstract. We are concerned with the barotropic compressible Navier–Stokes equations on the real line. Our primary goal is to establish the global well-posedness in a critical regularity framework in the case where the initial data are small perturbations of a stable constant stat...

CO 2 ‐to‐CO Electrochemical Conversion With an Fe(I) Porphyrin Complex in Water

ABSTRACT Iron porphyrin complexes constitute a well‐established and versatile class of molecular electrocatalysts for the reduction of CO 2 to CO. In both organic and aqueous media, the reaction mechanism is typically proposed to involve the interaction of CO 2 with a formally de...

Labyrinthula merlionensis sp. nov.: A Novel Labyrinthulid Infecting Marine Diatoms

Labyrinthulomycetes are a class of fungus-like heterotrophic protists from the Stramenopiles lineage, recognized for their ecological role as decomposers and contributors to nutrient cycling. They colonize various substrates, from seaweed to terrestrial environments, utilizing ec...