Centre National de la Recherche Scientifique

CRB3 and ARP2/3 regulate cell biomechanical properties to set epithelial monolayers for collective movement

Several cellular processes during morphogenesis, tissue healing or cancer progression involve collective cell migration. To set the cells for motion, there is an initial breaking of organization of the epithelial tissue that modifies the epithelial phenotype and axis of polarity....

Faithful Universal Graphs for Minor-Closed Classes

Abstract. It was proved by Huynh et al. [ Universality in Minor-Closed Graph Classes, preprint, arXiv:2109.00327, 2021] that any countable graph containing every countable planar graph as a subgraph has an infinite clique minor. We prove a finite, quantitative version of this res...

Evidence-Tiered Venomics of the BotG50 Toxic Fraction from Buthus tunetanus Reveals a Diversified Neurotoxin Repertoire

Scorpion venoms represent complex pharmacological arsenals whose complete molecular inventory remains incompletely defined, particularly for North African buthid species of high medical relevance. Buthus tunetanus is among the most clinically significant scorpion species across t...

Execution-Time Opacity in (Controllable) Timed Automata is Hard

International audience

Genomic determinants of penicillin G susceptibility and cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus bloodstream isolates.

BACKGROUND: This study aimed to describe penicillin G susceptibility, blaZ diversity, and genetic determinants of the cefazolin inoculum effect (CfzIE) among MSSA bloodstream isolates. METHODS: The first three non-duplicate MSSA isolates recovered each month from blood cultures a...

A New Analysis of the Mechanics of Fixed-Plug Tube Drawing with Application on a Low Carbon Steel Tube

Knowledge of the deformations that occur during the plastic forming of metals and the necessary forces is of key importance in engineering. The Fixed-Plug Tube Drawing (FPTD) process permits reductions of the diameter and the wall thickness of a tube to the desired geometry. In t...

Antichains for Concurrent Parameterized Games

Concurrent parameterized games involve a fixed yet arbitrary number of players. They are described by finite arenas in which the edges are labeled with languages that describe the possible move combinations leading from one vertex to another (n players yield a word of length n)....

Thickness-Dependent Spintronic Terahertz Emission in Molecular Beam Epitaxy-Grown PtTe2: From Semiconductor to Type-II Dirac Semimetal

Abstract Spintronic THz emitters are the most practical broadband sources, but their performance is constrained by the spin Hall conductivity of the conversion layer. We show that PtTe2, a type II Dirac semimetal, overcomes this limitation through thickness-driven electronic phas...

Scanning and active sampling behaviours emerge from conserved insect neural circuits

Navigating insects often pause and rotate to sample their surroundings, behaviours termed scanning. These and other active sampling behaviours embody navigational uncertainty and are key for spatial learning, yet their neural basis remains unclear and existing models impose scann...

A common germline 3′ UTR variant controls DDIT4 translation efficiency and stress responses in cancer cells

Systematic strategies for identifying and classifying variants that directly modulate ribosome engagement are lacking. Here, we develop and extensively validate a pipeline to identify translation-associated single-nucleotide polymorphisms (tranSNPs) by integrating analysis of tot...

Adoption of, attitudes towards, and perceived challenges of digital health in hospice and palliative care among professionals in Germany: a national cross-sectional web-based survey

Abstract Background Digital health technologies may support communication, symptom management, continuity of care, and access to services in hospice and palliative care. National data on their adoption, on professionals’ attitudes, and on perceived barriers are scarce. We examine...

A global consistent database of plankton and detritus from in situ imaging by the Underwater Vision Profiler 5

Plankton and detritus are essential components of the Earth's oceans influencing biogeochemical cycles and carbon sequestration. Climate change impacts their composition and fluxes, and marine ecosystems as a whole. To improve our understanding of these changes, standardized obse...

Steric‐Setup Effects on US East Coast Sea‐Level Change

Abstract The extent to which coastal sea levels co‐vary with open‐ocean variability is explored through evaluation of a balanced dynamics framework relating sea level with pressure, density, and velocity along the continental shelf and slope seafloor. Using high‐resolution region...

Marine arsenate evolution during Proterozoic oxygenation events and implications for biological phosphate metabolism

Abstract Earth’s atmosphere and oceans experienced two major episodes of ocean-atmosphere oxygenation that transformed the planet and shaped the evolution of the oxygen-rich biosphere between 2.45 and 0.541 billion years ago (Ga). These changes increased the abundance of oxidized...

Antibody-mediated immune surveillance as an organizing axis of gut microbiota structure

Abstract Background The symbiotic interplay between the immune system and the endogenous microbiome is essential for maintaining homeostasis. However, most microbiome research focuses primarily on associations between disease and microbial composition, often overlooking host–micr...

On convergence of the Mayer problems arising in the theory of financial markets with transaction cost

Abstract The geometric approach to multi-asset financial markets with proportional transaction cost prescribes embedding a specific model (of a stock market, of a currency market, etc.), usually given in a parametric form, into a natural framework defined by the two random proces...

Quantum Graph Theory by Example

Quantum graphs have been introduced by Duan, Severini, and Winter to describe the zero-error behaviour of quantum channels. Since then, quantum graph theory has become a field of study in its own right. A substantial source of difficulty in working with quantum graphs compared to...

Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells

Autophagy dysfunction and senescence are established drivers of aging, but their potential interaction remains poorly understood. Here we show that age-related decline of chaperone-mediated autophagy (CMA), a pathway for selective lysosomal protein degradation, changes senescent...

Interface engineered perpendicular magnetic anisotropy-controlled propagation of magnetic domain

We report the impact of ferromagnetic layer thickness and stack configuration on the magnetic properties, perpendicular magnetic anisotropy (PMA), modified magnetization switching mechanisms, and creep regime domain wall (DW) dynamics, including their propagation velocity, in a P...

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

The tumor microenvironment (TME) is a complex and heterogeneous milieu encompassing biological and biochemical events and diverse physical, chemical, and mechanical interactions between tumor and stromal cells. This heterogeneity plays a pivotal role in regulating tumor progressi...