Centre National de la Recherche Scientifique

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19 F NMR of Fluoroproline Residues

ABSTRACT Recently, the application of deep learning to structural data deposited in the Protein Data Bank has enabled the reliable and accurate prediction of 3D folded structures of proteins from their sequences. However, this approach is not applicable to highly dynamic proteins...

Constitutive natural killer cell features associated with post-treatment control of SIV infection in the pVISCONTI study

Abstract Post-treatment HIV controllers (PTC) offer a unique opportunity to uncover the determinants of durable remission after antiretroviral therapy (ART) interruption. Here, using six PTC and six post-treatment non-controllers from the pVISCONTI study in cynomolgus macaques, w...

Earliest simultaneous multi-color optical observations of GRB 230328B: from 41 seconds to the host-galaxy identification

Abstract We present a multiwavelength study of the long-duration gamma-ray burst GRB 230328B, combining prompt γ-ray observations with exceptionally early simultaneous optical photometry and extensive X-ray, radio, and host-galaxy follow-up. NUTTELA-TAO began simultaneous g′r′i′...

Vulnerable microbial communities in Atacama-Altiplano wetlands: modern analogs of ancient ecosystems with implications for sustainability and conservation

Abstract The Altiplano-Puna plateau lies at ∼4,000 m above sea level in the volcanic Andes cordillera. Together with the adjacent Atacama Desert, it forms one of the most hyperarid regions on the planet. Wetlands are rare, influenced by hydrothermalism and, due to high evaporatio...

From water to land: evolution of tRNA gene repertoires in photosynthetic organisms

Abstract Photosynthetic eukaryotes have undergone evolutionary shifts from aquatic to terrestrial habitats, accompanied by changes in genome organization and gene regulation. Yet, the evolution of transfer RNA (tRNA) gene repertoires has received limited attention despite their c...

Genetics in Heterotaxy: A Case Series and Literature Review on DNAH9 , PKD1L1 , MMP21 , and GDF1

Heterotaxy (HTX) is a rare condition characterized by complex congenital heart defects and a wide spectrum of extracardiac abnormalities that significantly impact survival. While molecular diagnosis is essential for clinical management, next-generation sequencing (NGS) currently...

Anticancer and Cardioprotective Properties of Medicinal Mushrooms: Current Evidence and Future Prospects

Introduction: Cardiotoxicity is an undesirable side effect of chemotherapy that limits the effectiveness of cancer treatment. Almost all cardiotoxic agents cause cardiovascular complications, leading to oxidative stress and other pathological conditions. The search for bioactive...

Cuproptosis: an emerging member of the immunogenic cell death family

Cell death was long considered the terminal consequence of cellular stress or damage, and distinct cell death modalities were classified according to their molecular execution mechanisms rather than their immunological impact [ 1 , 2 ]. This reductionist view has progressively be...

Facing Yourself: A Proxemic Approach to Self-Dyadic Interactions in VR

Virtual Reality (VR) provides a powerful framework for studying human social interactions, yet generating realistic and diverse interaction data remains a major challenge. Asynchronous Interaction (AsI) paradigms offer a promising alternative by enabling users to interact with th...

Sex of central neurons controls intestinal niche signalling to drive sex differences in stem cell activity and cancer susceptibility

Abstract Sex differences in cancers arising in non-reproductive organs are widespread. While sex hormones and the intrinsic sexual identity of cancer cells are well-established contributors, it is unknown whether other mechanisms are involved. Here, we reveal an unexpected source...

How Does Motion-to-Photon Latency Influence the Perception-Action Loop

The perception-action loop plays an essential role in sports performance. Virtual reality is increasingly used to train this loop because it provides a controlled setting. However, motion-to-photon latency, the delay between the user’s real and virtual motion, may disrupt user ex...

Biomarkers in facioscapulohumeral muscular dystrophy

PURPOSE OF REVIEW: Facioscapulohumeral muscular dystrophy is one of the most frequent myopathies. Its clinical presentation and genetic background are unique. FSHD needs reliable and measurable biomarkers to monitor the disease and assess the efficacy of therapeutic approaches. T...

Constructive characterisations of the must -preorder for asynchrony

De Nicola and Hennessy's must -preorder is a liveness preserving refinement which states that a server q refines a server p if all clients satisfied by p are also satisfied by q . Owing to the universal quantification over clients, this definition does not yield a practical proof...

Infrastructuring short food supply chains: how intermediaries bind rules, norms and values

Food supply chains are crucial for food security and socio-economic development, yet their length concentrates value away from producers and consumers disproportionate resources. As the COVID-19 pandemic and the wars in Ukraine and Iran exposed, overreliance on long chains produc...

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19 F NMR of Fluoroproline Residues

ABSTRACT Recently, the application of deep learning to structural data deposited in the Protein Data Bank has enabled the reliable and accurate prediction of 3D folded structures of proteins from their sequences. However, this approach is not applicable to highly dynamic proteins...

Experimental mineralogical replacement to investigate the role of texture on interface morphology, reaction kinetics and pore-scale transport during metasomatism

Dolomitization is a key diagenetic process that reorganizes porosity and permeability in carbonate rocks, yet the coupling between interface kinetics and transport heterogeneity remains poorly constrained. We performed time-resolved hydrothermal dolomitization (metasomatism) expe...

From Top to Bottom: Manufacturing Process‐Context Aware Resolution of Energy Device Electrodes Through a 3D Diffusion Generative Model

ABSTRACT Optimization of electrochemical energy storage and conversion devices often depends on the electrode microstructure properties, of which its 3D representation provides the most complete link between manufacturing process and device performance. Deep generative models can...

Characterising caregivers’ contingent responses: Short, slow, and clear speech facilitates infant turn-taking

Bidirectional temporal contingency in infant-caregiver interaction is believed to be instrumental in shaping the development of turn-taking and speech. Likewise, caregivers are known to modulate their voices in a distinctive register when speaking to infants. Yet, less is known a...

Epithelial–mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis

Epithelial–mesenchymal transition (EMT), historically described as a binary morphological change from an epithelium to a mesenchymal state, no longer adequately accounts for carcinoma cell phenotypes observed in patients. Single-cell sequencing, spatial-omics, and lineage tracing...

Entropy maximization and weak Gibbsianity of quasi-free fermionic states

Abstract In their 1972 study of approach to equilibrium, Lanford and Robinson showed that gauge-invariant quasi-free states of lattice fermions maximize entropy among all translation-invariant states with a fixed two-point function and suggested that the maximizer is unique. In s...