Centre National de la Recherche Scientifique

Drawing the line: Clarifying fungal allorecognition from HET domains to het genes to heterokaryon incompatibility

The iconic networks of filamentous fungi are connected through hyphal fusions. While fusion is beneficial among hyphae from the same fungal individual, fusion between individuals (i.e., heterokaryon formation) risks infection by parasites or pathogens. Across fungi, multiple sets...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...

Reduced Complexity Model Intercomparison Project phase 3: experimental protocol for coordinated constraining and evaluation of reduced-complexity models

Abstract. Reduced-Complexity Models (RCMs) are a critical tool for synthesising climate science knowledge and providing climate projections for a wide range of emissions scenarios. The Reduced-Complexity Model Intercomparison Project (RCMIP) provides a framework for the coordinat...

Non-invasive multiparametric characterization of essential thrombocythemia, premyelofibrosis, and overt myelofibrosis

Among myeloproliferative neoplasms (MPN), prefibrotic myelofibrosis (preMF) was defined as a distinct entity from essential thrombocythemia (ET) and primary overt myelofibrosis (PMF) since the 2016 revision of the World Health Organization (WHO) classification, while precise char...

Very‐Long‐Period Seismic Signals During Lateral Dike Propagation at Piton de La Fournaise Volcano

Abstract We report a previously undocumented sequence of very long period (VLP) signals preceding the September 2022 eruption at Piton de la Fournaise. These events occurred during lateral magma propagation and exhibit quasi‐periodic sawtooth‐shaped displacement transients. Seism...

Development and Characterization of Functionally Graded Sisal/Glass Fiber-Reinforced Polymer Composites

Structural applications require materials that provide an optimal balance of strength, durability, and sustainability. This study develops functionally graded sisal/glass fiber-reinforced polymer composites and evaluates their tensile, compressive, and flexural properties, as wel...

Multi‐Scale Investigation of Supramolecular Organogels Assembled From Pt(II)‐Salphen Complexes

Supramolecular metallogels based on platinum(II) complexes have attracted growing interest due to their tunable photophysical properties. However, the potential of Pt(II)-salphen complexes as low-molecular-weight gelators remains largely unexplored. Here, we report a series of Pt...

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors

Fibroblast growth factor receptor 3 ( FGFR3 ) is one of the most frequently altered genes in bladder cancer, primarily through activating mutations that drive oncogenesis and are enriched in luminal tumors. However, the underlying gene regulatory network (GRN) remains poorly char...

Identification of Activity, Insulin, and Dietary Thresholds Associated With Exercise‐Related Hypoglycaemia and Hyperglycaemia in Children With Type 1 Diabetes: A Free‐Living Study Using Explainable Machine Learning

ABSTRACT Aims Some studies have explored associations between physical activity (PA) and hypoglycaemia in real‐life in type 1 diabetes (T1D) but without fully accounting for two major confounders, diet and insulin. We aimed to identify thresholds of PA characteristics, insulin, a...

Pancreatic panniculitis as the sole manifestation of pancreatic ductal adenocarcinoma: a case report

Pancreatic panniculitis is a rare form of lobular panniculitis characterized by subcutaneous fat necrosis occurring at cutaneous sites distant from the pancreas. It is most often associated with pancreatitis, while pancreatic malignancies — dominated by acinar cell carcinoma — re...

Coprime extensions of indecomposable solutionsto the Yang–Baxter equation

We introduce a method to extend involutive nondegenerate set-theoretic solutions to the Yang-Baxter equation by means of equivariant mappings to graded modules, thus leading to the notion of a twisted extension.Furthermore, we define coprime extensions of solutions and prove that...

How personality traits interact with social identity in the formation of social networks? A case study in South India

Using original data from rural South India, we examine how personality traits intersect with caste and gender to shape interpersonal network characteristics in a Global South context. We analyse the relationship between four personality traits (emotional stability, plasticity, co...

Flat Left-Invariant Lorentzian Metrics on Almost Abelian Lie Groups

Abstract Almost abelian Lie groups are those admitting a normal subgroup which is commutative and of codimension one. We determine all Lie algebras of almost abelian Lie groups admitting a left-invariant Lorentzian metric of vanishing curvature. For each of those algebras, we com...

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Therapeutic needs to modulate brain circuits highlight graphene-based materials (GBMs) as an emerging tool to engineer specific interventions to treat neuro-diseases. In this context, graphene oxide (GO) nanosheets offer new drug delivery strategies to reach neural cells and sign...

Genetic screening identifies WNT5A/RYK as a determinant of extracellular vesicle fate

Extracellular vesicles (EVs) are natural mediators of intercellular communication through the transfer of cytoplasmic material from donor to recipient cells. The molecular mechanisms governing EV uptake and cargo delivery in recipient cells remain largely elusive. To address this...