Centre National de la Recherche Scientifique

Transarterial embolization in musculoskeletal care: an indication-stratified narrative review

Abstract Background Transarterial embolization (TAE) is increasingly used across a broad spectrum of musculoskeletal conditions, ranging from established hemostatic and tumor-related indications to emerging pain-directed procedures for degenerative joint disease and chronic infla...

Real‐Time Observation of Soliton Buildup and Self‐Organization in a GHz Harmonic Mode Locked Fiber Laser

ABSTRACT Ultrafast fiber lasers operating at GHz repetition rates are critical for applications requiring high‐speed optical pulse sources. To achieve such rates, passive harmonic mode locking (HML) constitutes a logical pathway, whose practical implementation is hampered by the...

Universal random matrix behavior of a Fermionic quantum gas

Since its initial use by Wigner in describing heavy atom spectra, random matrix theory (RMT) has found applications and revealed universal laws in diverse physical contexts, from quantum field theory to disordered systems and wireless communications. A particularly compelling app...

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

Estradiol (E2) regulates ovarian follicular development and granulosa cell (GC) function primarily through estrogen receptor β (ERβ). Human GCs express several ERβ isoforms, including ERβ1, ERβ2, ERβ4, and ERβ5, but how their relative abundance modulates estrogen signaling remain...

A DNA methylation–based risk score improves prognostic stratification in myelodysplastic neoplasms

Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and variable risk of progression to acute myeloid leukemia (AML). Although mutational data are already implemented into the most recent MDS risk models, (i.e...

A multiday outdoor festival combining breathwork and cold water immersion is associated with reduced trait anxiety in a naturalistic pre-post study

Abstract Breathwork and cold exposure attract growing public interest, yet little is known about their psychological effects in real-world multi-day formats, and most evidence concerns acute physiological or state-level outcomes rather than more dispositional markers. This natura...

Design principle for mitigating moisture-induced degradation in 2D halide perovskites

We establish a conceptual framework which explains and mitigates moisture-induced degradation in 2D perovskites. Degradation proceeds along defined pathways across the spacer cation iodide (A′I or A′I2)-PbI2-H2O ternary phase diagram as moisture intercalates into the perovskite....

A quantitative methodology for analysing physical damage and recovery dynamics from concurrent and consecutive hazards: forensic insights from Puerto Rico

Space and time play a crucial role in multi-hazard impact assessment. When two or more natural hazards occur simultaneously or in sequence at the same location, the physical integrity of assets and infrastructures can be compromised, and the resulting damage can be greater than t...

Boundary regularity for the polyharmonic Dirichlet problem

In this paper we prove that any solution of the m -polyharmonic Poisson equation in a Reifenberg-flat domain with homogeneous Dirichlet boundary condition, is 𝒞 m - 1 , α regular up to the boundary. To achieve this result we extend the Nirenberg method of translations to operator...

From Morse functions to Lefschetz fibrations on cotangent bundles

We prove that, for any Morse function on a compact manifold and any adapted gradient satisfying the Morse–Smale condition, there is a homotopically unique complex-valued symplectic Lefschetz fibration on the cotangent bundle whose restriction to the zero-section is the given func...

Unsupervised deep generative models for anomaly detection in neuroimaging: A systematic scoping review

Unsupervised anomaly detection (UAD) based on deep generative modelling has been increasingly investigated for identifying pathological brain abnormalities without requiring voxel-level annotations. By learning the distribution of healthy anatomy and generating pseudo-healthy rec...

Design, Synthesis and Biophysical Characterisation of CPP‐PNA Conjugates for Targeting Oncogenic microRNA‐221

Peptide nucleic acids (PNAs) are a promising platform targeting disease-associated microRNAs due to their high binding affinity, excellent sequence specificity and resistance to enzymatic degradation. However, their therapeutic application is often limited by inefficient cellular...

Neurofeedback enhances a neural signature of selective attention to speech in cocktail-party settings

Understanding speech in noisy situations is challenging and often fails due to attentional rather than sensory deficits. We report here that neurofeedback can enhance a neural signature of selective attention to speech in a cocktail-party setting. Neural responses to speech were...

Subadditivity and optimal matching of unbounded samples

We obtain new bounds for the optimal matching cost for empirical measures with unbounded support. For a large class of radially symmetric and rapidly decaying probability laws, we prove for the first time the asymptotic rate of convergence for the whole range of power exponents p...

Accelerating Identification of Relevant Polarons in Batteries

Abstract Many of the materials under consideration as battery electrodes are known to exhibit polarons─charge carriers localized through polarizing their environments, which are unfortunately quite costly to tackle by theory. Next to costly ab initio methods and geometry optimiza...

Quantum propagation for Berezin–Toeplitz operators

We describe the asymptotic behaviour of the quantum propagator generated by a Berezin–Toeplitz operator with real-valued principal symbol. We also give precise asymptotics for smoothed spectral projectors associated with the operator in the autonomous case; this leads us to intro...

TAIL EXPECTILE ESTIMATION IN THE SEMIPARAMETRIC GENERALIZED PARETO MODEL

Expectiles have received increasing attention as a market risk measure that is both coherent and elicitable. They are defined as a least squares analog to quantiles. Their estimation from heavy-tailed loss data in an extreme value framework is an important and difficult problem,...

Correlative microscopy reveals chemical short-range order and native oxide in medium-entropy alloys

High- and medium-entropy alloys can exhibit exceptional sets of mechanical and catalytic properties underpinned by the vast array of local atomic arrangements. Among the key features governing properties is the self-assembly of specific atomic neighborhoods, a process known as ch...

Nonlocal Hamilton–Jacobi Equations on a network with Kirchhoff type conditions

In this article, we consider nonlocal Hamilton–Jacobi Equations on networks with Kirchhoff type conditions for the interior vertices and Dirichlet boundary conditions for the boundary ones: we provide general existence and comparison results in the case when the nonlocal operator...

Overcoming Reversibility: Borrowing Hydrogen Enables Enantioselective Intermolecular Oxa-Michael Addition to α,β-Unsaturated Aldehydes

Abstract Chiral 1,3-dioxygenated motifs are key scaffolds in bioactive natural products, yet their synthesis via intermolecular oxa-Michael addition to α,β-unsaturated aldehydes remains challenging notably due to the high reversibility of the oxygenated nucleophile addition. This...