Centre National de la Recherche Scientifique

Serotype-independent inhibition of S. pneumoniae by SMiTE, a commensal-derived bacteriocin

ABSTRACT Streptococcus pneumoniae remains a leading cause of disease despite widespread vaccination, highlighting the need for serotype-independent strategies. We recently identified commensal streptococci that produce bacteriocins with anti-pneumococcal activity. Here, we evalua...

Celastrol and Its Derivatives in Breast, Ovarian, and Cervical Cancer: Molecular Targets, Signalling Networks, and Nanocarrier-Based Delivery

Celastrol, a quinone methide pentacyclic triterpenoid obtained mainly from the roots of Tripterygium wilfordii Hook. f., forms covalent, often reversible, adducts with cysteine thiols in regulatory proteins, which underlies its multi-targeted action. This review summarises the pr...

Resolution Dependence of the Climate Feedback Parameter in Km‐Scale Climate Models

Abstract Global storm‐resolving models (GSRMs) provide new opportunities to investigate the climate response to warming with explicitly resolved deep convection. However, the limited number of existing studies has so far precluded the systematic assessment of similarities and dif...

Maximal elements in the Hurwitz graph

The Hurwitz graph has as its vertices the maximal chains in the lattice of non-crossing partitions, with an edge between two chains which differ at exactly one place. Adin and Roichman introduced an order on this graph by choosing a base element and showed that the maximal elemen...

Degradation Mechanisms for Automotive PEMFCs Under Dynamic Operation and Mitigation Strategies for Start-Up/Shut-Down: A Comprehensive Review

Proton Exchange Membrane Fuel Cells (PEMFCs) offer a compelling solution for heavy-duty and light-duty vehicle electrification due to their high efficiency and zero-emission operation. Despite these advantages, limited operational durability remains a critical barrier to widespre...

DREAM D6.9_RP2 update of DMP

The purpose of the DREAM project's Data Management Plan (DMP) is to plan the management of the data which is being generated, collected, and processed in the framework of the project. The DMP ensures the data is managed according to the Horizon Europe FAIR principles (Findability...

Accurately Probing [Fe(CN)6] Defects in Prussian Blue Analogues

Abstract Prussian blue analogues AxM[Fe(CN)6]1–y·zH2O (A = Na, K, M = Fe, Mn) possess a rich crystal chemistry that allows their use as insertion materials for batteries, water treatment, and smart windows, among others, applications. Despite being simple in appearance, their syn...

Nonclassical condensation pathways revealed by the multivariable theory of nucleation

Classical nucleation theory (CNT) provides a simple conceptual framework for nucleation but often fails to quantitatively reproduce experimental and numerical observations. In this work, we extend the theory by explicitly incorporating the multidimensional nature of nucleation an...

Double periodicity of the AnkyrinG-associated complex in the axon initial segment

The axon initial segment (AIS), situated within the first 20 to 60 µm of the axon, is essential for action potential generation and maintenance of axonal identity [M. N. Rasband, Nat. Rev. Neurosci. 11 , 552–562 (2010)]. Its structure relies on the beta (β)-IV-spectrin/AnkyrinG (...

Thermoelasticity of mixed-mode cracks in layered transversely isotropic half-spaces

A three-dimensional spectral formulation is developed for steady thermoelastic penny-shaped cracks embedded in layered transversely isotropic half-spaces, with arbitrary stacking sequences and mechanically compliant and thermally resistive interfaces. Its central feature is a com...

The enhanced capabilities of mid-infrared limb emission sounding to observe stratospheric aerosol injection geoengineering

Abstract. Using a model-based pseudo-reality (PR) future scenario and realistic pseudo-observations (POs) representative for a proposed satellite mission concept (CAIRT – the Changing-Atmosphere Infra-Red Tomography explorer), we analyse the capabilities of a high-spectral-resolu...

Superinfection exclusion strategy of siphophage T5: analysis of the FhuA:Llp complex

ABSTRACT Superinfection exclusion is a widespread viral mechanism that protects the infected cell from overinfection by other identical or closely related viruses. Shortly after infection by bacteriophage T5, the bacterium Escherichia coli produces Llp, encoded by the newly injec...

Resolving the LiFePO4 Battery State beyond Voltage-Based Diagnostics Using Surface-Scan MRI

Reliable assessment of state of charge (SoC) and state of health (SoH) in commercial batteries remains a major challenge because their closed architecture obscures the underlying electrochemical, structural, and thermal processes, while existing diagnostic methods often provide o...

Non-linear mechanical field reconstruction coupling recurrent neural networks with physics-informed graph neural networks

Reconstructing local stress fields in heterogeneous microstructures under non-linear, history-dependent loading remains a major computational bottleneck in multi-scale simulations. We propose a coupled LSTM-GNN framework that links the temporal and spatial aspects of local stress...

Unraveling Vulnerabilities and Pathways Responsible for AITL Malignancy to Improve Patients’ Treatment

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphoma characterized by poor clinical outcomes following conventional CHOP-based chemotherapy and the lack of effective disease-specific therapeutic options. The disease finds its origin in...

Improving the CLASSIC (v1.8) snow model to better simulate Arctic snowpacks

Abstract. This study enhances the snow model of the Canadian Land Surface Scheme including Biogeochemical Cycles (CLASSIC), with a particular focus on Arctic environments. Key snow model physics improvements include adjustments to the thermal conductivity at the top of the first...

The OpenSat4Weather dataset: Ku-band satellite link data for precipitation monitoring

Abstract. The TV-SAT signals received by the ground antennas of Satellite Microwave Links (SMLs) can be opportunistically used for identifying and quantifying precipitation. Hence, SMLs can serve as low-cost rainfall sensors complementary to conventional instruments. However, a s...

Temperature sensitivity of snow viscoplasticity: Evidence from controlled creep experiments

Abstract. Snow is a warm, porous material whose densification under its own weight is highly temperature-dependent. Despite decades of research, reported activation energies for snow viscoplasticity remain highly scattered, ranging from 40 to 600 kJ mol-1. We quantified the tempe...

Error-Controlled Mixed-Precision Cholesky Factorization with MX Microscaling Formats

Existing tile-centric mixed-precision Cholesky factorization, as used in recent Gordon Bell campaigns, is based on a heuristic that bounds only rounding contribution while ignoring underflow when classifying tiles for different IEEE floating point precisions. Direct application t...

HCV incidence and prevalence trends among people who use drugs in France 2004 to 2023

Abstract Hepatitis C virus (HCV) remains a key public health challenge, particularly among people who use and inject drugs (PWUD, PWID). While direct-acting antivirals (DAA) have revolutionized HCV treatment, meeting the WHO’s 2030 elimination target requires accurate estimation...