Centre National de la Recherche Scientifique

Machine learning-based rescoring with MS²Rescore boosts peptide identification and taxonomic specificity in metaproteomics

Abstract Background Metaproteomics, the study of the collective proteome within microbial ecosystems, has gained increasing interest over the past decade. However, peptide identification rates in metaproteomics remain low compared to single-species proteomics. A key challenge is...

A new approach to measuring liquid metal density at high pressure and high temperature using aerodynamic levitation

Accurate knowledge of liquid metal density and its temperature dependence is essential for understanding phase transformations, thermophysical behavior, and the safe design of high-temperature engineering systems. While numerous techniques have been developed to measure the densi...

The Collective Action of Firms on Regulatory Science: Mechanistic Toxicology as a Market‐Making Epistemic Strategy in the R&D Agrochemical Industry

ABSTRACT The influence of agrochemical firms on testing and risk assessment standards constitutes a central yet understudied dimension of the political economy of agrochemicals and the formation of a corporate‐dominated global pesticide regime. How leading R&D firms—formally posi...

Mathematical Explanations and Axioms as Rules

Abstract This paper bridges two distinct traditions – philosophy of mathematics and proof theory – to provide a formal framework for explanatory proofs in mathematics. We focus on explanatory proofs that uncover the grounds of mathematical theorems, and we formalize their structu...

Micro-scale organization of non-cyanobacterial diazotrophs drives nitrogen fixation in marine particles

Abstract Dinitrogen (N₂) fixation supplies reactive nitrogen to the ocean, and non-cyanobacterial diazotrophs (NCDs) are increasingly recognized as contributors. Marine particles have been theorized as hotspots where low oxygen and labile carbon favor N₂ fixation by NCDs, but emp...

Bridging the gap between genomic, phenotypic, and modeling data in picophytoplankton–virus interactions

Abstract We present a comprehensive synthesis of recent developments in methodological approaches to combine experimental and genomic studies of picophytoplankton–virus interactions. This synthesis will not only enhance our understanding of these relationships but also stimulate...

Biodegradability test on a corn starch based compostable plastic bag: impact of moisture on CO2 emissions, microbial communities, and enzymatic activities

Compostable plastics are often considered as a solution for minimizing plastic contamination due to their biodegradation capacity in composting processes. However, the standards evaluating their biodegradability do not encompass the variability of uncontrolled composting systems,...

A Baltimore-modified non-TBI conditioning for allogeneic stem cell transplantation in elderly or unfit patients with haploidentical or mismatched donors

Abstract Background: The Baltimore conditioning regimen is nowadays one of the most used reduced-intensity conditioning (RIC) regimens, although access to total body irradiation (TBI) may be challenging in some centers. Objective: The aim of this study was to evaluate the outcome...

Study of Supernova Neutrinos at ESSnuSB

In this paper, we have studied the sensitivity of the ESSnuSB far detector to supernova neutrinos. ESSnuSB is a proposed long-baseline neutrino experiment in Sweden, which will use a 538 kt water Cherenkov detector to probe the leptonic phase δCP by studying the second oscillatio...

Topological Reinforcement of Rhizosphere Microbial Networks Facilitates the Invasive Superiority of Spartina anglica

Rhizosphere microbial interaction patterns underpin the resilience and dominance of invasive plants in fluctuating coastal salt marshes. We compared the rhizosphere microbial communities of the invasive Spartina anglica and the native Spartina maritima across varying distances fr...

210Pbex in lacustrine sediments: A half-century global synthesis (1977-2024)

Unsupported 210 Pb ( 210 Pb ex ) is a naturally occurring radionuclide widely used to establish sediment chronologies spanning the past ∼150 years, thereby providing high-resolution temporal frameworks for palaeolimnological reconstructions. Since the late 1970s, numerous hypothe...

TMD factorization in diffractive heavy quark production in photon-nucleus collisions

A bstract Using the Colour Glass Condensate effective theory, we study the diffractive production of a massive quark-antiquark pair accompanied by a gluon in coherent photon-nucleus collisions at high energy. This partonic configuration provides the leading twist contribution to...

Geometry-driven jets underlie dispersal of plants and fungi by raindrops

The impact of droplets on concave surfaces is poorly understood, although it is relevant to a mode of dispersal of reproductive units that has evolved independently in several species of plants and fungi. This mode of dispersal relies on splash-cups, specialized organs that use r...

InN Nanowires on Si⟨111⟩ and Si⟨100⟩ for Monolithic Short-Wave Infrared (SWIR) Photodetectors

Abstract InN nanowires were grown on Si⟨111⟩ and Si⟨100⟩ substrates by plasma-assisted molecular beam epitaxy using a thin AlN buffer layer at temperatures compatible with the thermal budget limitation imposed by back-end-of-line processing. Reflection high-energy electron diffra...

First characterization of Staphylococcus felis in diabetic foot osteomyelitis: from intracellular persistence to phage treatment

ABSTRACT Staphylococcus felis is a coagulase-negative Staphylococcus (CoNS) primarily associated with the feline microbiota and only rarely reported in human disease. Here, we report its implication in diabetic foot osteomyelitis, and provide the first comprehensive characterizat...

Efficient power generation near room temperature in earth-abundant thermoelectric tin sulfide via lattice ordering

The inefficient carrier transport of earth-abundant tin sulfide (SnS), arising from its intrinsically low crystal symmetry, limits its thermoelectric performance at low temperatures. Here, the substitutional Ag+ doping modifies the Na-doped SnS crystal structure by reinforcing la...

A novel 5-FU derivative chemotherapy: a promising pan-cancer treatment to improve antitumor efficacy and overcome therapy resistance

Abstract Management of advanced solid cancers remains challenging, particularly after the development of therapeutic resistance. Here, we synthesized a library of phosphonium-substituted 5-fluorouracil (5-FU) derivatives and evaluated their anticancer activity across multiple tum...

Similar pre-eruptive conditions behind contrasting explosive and effusive trachytic eruptions at Montagnone (Ischia volcano, Italy)

Abstract Most volcanoes on Earth display a range of eruptive styles, varying between effusive and explosive activity. Understanding the factors controlling these transitions is critical for volcanic hazard assessment but remains debated. While both pre-eruptive storage conditions...

Moving bottlenecks in traffic flows: a well-posed fully coupled nonlocal PDE-ODE model with time delay

We propose a nonlocal PDE-ODE strongly coupled system describing the interaction between traffic flow and a moving bottleneck, induced by e.g. a controlled vehicle. The bulk traffic density evolves according to a nonlocal scalar conservation law with time delay, while the bottlen...

TurboID ‐based proteomic profiling reveals proxitome of the IRT1 metal transporter and new insight into IRT1 endocytosis

Summary Iron Regulated Transporter1 (IRT1) is the major root iron transporter responsible for broad‐spectrum metal absorption in Arabidopsis thaliana root epidermal cells. Non‐iron metal substrates of IRT1 were recently shown to regulate IRT1 cell surface levels by endocytosis an...