Centre National de la Recherche Scientifique

Computer-Aided Entrainer Design for Extractive Distillation Using Infinitely Sharp Splits

Abstract We present an integrated product-process design framework for ranking heavy entrainer candidates for minimum-boiling azeotrope separation, corresponding to the Serafimov class (1.0-1a), the most common such case. The framework combines computer-aided molecular design (CA...

A molecular safeguard in Escherichia coli Braun’s lipoprotein (Lpp) biogenesis

ABSTRACT Braun’s lipoprotein (Lpp) is the most abundant protein present in Escherichia coli . Lpp is an outer membrane (OM) lipoprotein that contributes to the mechanical integrity of the cell envelope by tethering the OM to the underlying peptidoglycan (PGN). It has long been kn...

Maillet-type theorem for some inhomogeneous linear systems of regular Gevrey-type partial differential equations

In this article, we are interested in the Gevrey properties of the formal power series solutions in time of some inhomogeneous linear systems of regular Gevrey-type partial differential equations with analytic coefficients at the origin of C N + 1 . We systematically examine the...

Engineering Ultra‐Low Fe or Ni Loading in Polymer Derived SiCN(O) Fibre Mats: Exploring the Performance towards Alkaline OER

ABSTRACT In this study, Fe or Ni‐anchored silicon carbo(xy)nitride (SiCN(O)) fibre mats were synthesized via the polymer‐derived ceramics (PDC) approach to investigate their electrocatalytic performance toward alkaline OER. The resulting fibrous‐supported pre‐catalysts formed por...

Settlement and Landscape Transformations in the Khaybar Oasis From Late Antiquity to the Late Islamic Period

ABSTRACT Archaeological survey and targeted soundings by the Khaybar Longue Durée Archaeological Project ( Khaybar LDAP ) have provided the opportunity to reconstruct a first overview of settlement dynamics, land use and socioeconomic organisation from the late pre‐Islamic period...

On the Timescales of Atmospheric Adjustments to Contrail Cirrus Formation

Abstract Condensation trails (contrails) that evolve into contrail cirrus may constitute the largest contribution to aviation's climate impact. However the strength and timescales of the adjustments of the upper atmospheric water budget to contrail formation are poorly known. Tha...

KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer

Immunotherapy has emerged as a revolutionary therapeutic approach to treat cancer showing remarkable clinical responses. However, its efficacy in solid tumours such as prostate cancer (PCa) remains very limited due to a highly immunosuppressive tumour immune microenvironment (TIM...

The GPCRVP score reliably predicts the impact of GLP1R human variants on receptor function

Abstract Aims/hypothesis The glucagon-like peptide-1 receptor (GLP1R) is a key regulator of glucose homeostasis and body weight, and a major therapeutic target for type 2 diabetes and obesity. Individual disease risk and response to treatments may vary widely depending on the pre...

MiR-662 impairs C/D box snoRNA expression and rRNA 2′-O-ribose methylation marks

MiR-662 overexpression has been reported to promote breast cancer metastatic progression and to impair the expression of genes encoding for proteins involved in translation, ribosome biogenesis and ribosome processing (Puppo et al., 2023); however, the relationship between miR-66...

Tunnel collapses and adaptive support at rock-soil interfaces under low-to-medium overburden in tectonically disturbed rock masses

Tunnel stability in tectonically disturbed rock masses remains particularly challenging near rock–soil interfaces, where abrupt stiffness contrasts and heterogeneous geological structures can trigger collapse mechanisms that conventional rock mass classification systems do not ad...

Can one hear the shape of a crack in a drum? Spectral fingerprints and a data-driven perspective

Abstract This paper investigates whether the shape of a crack in a membrane can be identified from the corresponding Laplace spectrum. To this end, analytical results are derived using the short-time asymptotic expansion of the heat trace, a fundamental spectral invariant. The an...

Mechanochemical Hydrazone Synthesis From Isoniazid and Isophthalaldehyde: Kinetics and Process Optimization of a Competitive‐Consecutive Reaction

ABSTRACT Mechanochemistry has emerged a greener and more efficient alternative to solution‐based methods for hydrazone synthesis. However, prior studies have predominantly focused on final yields, reaction times, and biological activities, while giving limited attention to reacti...

Mechanisms of non-monotonic signal dependence on repetition rate in high-repetition-rate nanosecond LIBS

High-repetition-rate nanosecond laser-induced breakdown spectroscopy (LIBS) offers advantages such as small ablation crater and high signal-to-noise ratio. To investigate the non-monotonic influence of repetition rate on signal intensity, we conducted high-repetition-rate LIBS ex...

A CsWRKY46-CsPBL9-CsARI1 tripartite regulatory module coordinates H2O2 production and callose deposition in citrus fruit immunity

Plant immunity against pathogens involves multiple immune responses and intricate regulatory networks. However, how immune networks are deployed in fruit remains poorly understood. Here, we show that citrus fruit immune responses, including hydrogen peroxide (H 2 O 2 ) production...

The Characteristic Group of Lie LCP Manifolds

Abstract The (reduced) characteristic group of a locally conformally product manifold is obtained by restricting the action of its fundamental group to the non-flat factor of the universal cover, and taking the connected component of the identity in the closure of this restrictio...

General heat release rate surrogates for NH3/H2/N2 and H2 flames using Raman/Rayleigh/LIF accessible species

Accurate estimation of the heat-release rate (HRR) is essential for understanding and controlling ammonia–hydrogen combustion, yet conventional experimental surrogates are strongly dependent on operating conditions and typically rely on radicals measured by laser-induced fluoresc...

Generalizable and equitable automated ischaemic stroke lesion segmentation with vision transformers

Abstract Background Ischaemic stroke, a leading cause of death and disability, relies on neuroimaging for characterising the anatomical pattern of injury. Diffusion-weighted MRI (DWI) provides the most anatomically specific signal in acute ischaemic stroke but poses substantial c...

Net carbon losses in Central African forests revealed by high-resolution biomass change maps

Dense humid forests in Central Africa hold vast biomass carbon stocks but are increasingly affected by small-scale disturbances that are difficult to detect with current satellite observations. Here, we generate 10 m canopy height maps for 2019–2022 using deep learning with space...

Comparative evaluation of tip diameter of different gutta-percha cones according to ISO 6877 measurement method and direct measurement method: an in vitro study

Objectives: To evaluate sealing ability of root canals obturated with bioceramic-impregnated gutta percha cone (BCC) or gutta percha (GP), with bioceramic sealer (BCS) or AH Plus (AH; Dentsply-Maillefer), in roundly-prepared canals using matched single-cone technique, based on ba...

Flying through the plasmasphere to optimize low-energy ion measurements

The Juice flyby of Earth in August 2024 gave us the first chance to evaluate the performance of the Jovian Plasma Dynamics and Composition analyzer (JDC) in environments similar to those expected at Jupiter. JDC is one of the sensors belonging to the Particle Environment Package...